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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 184-185,208

MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
Citation: MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
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Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules

  • Departhment of pharmacy,85th Hospital of PLA,Shanghai 200052,China

  • Received Date: 2010-01-15
  • Rev Recd Date: 2010-02-22
  • Objective To prepare the andrographolide self-emulsifying drug delivery soft capsules(ASESC) and evaluate its quality. Methods The andrographolide self-emulsifying soft capsules were prepared.To screen the dissolution of andrographolide,the dissolution media and dissolution method of Ch.P were analysied.The dissolution of SMESC was measured,taking the commercial capsule as reference. Results The self-emulsifying drug delivery system was composed of ethyl oleate(10%),Tween 80(54%),n-Butanol(36%).The percent of accumulated dissolution of andrographolide in self-emulsifying drug delivery soft capsules in 0.2% SDS fluid was up to 70% at 45 min,which was far more than the commercial capsule. Conclusion The andrographolide self-emulsifying drug delivery capsules has been successfully prepared,and the dissolution of andrographolide was remarkably improved.
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Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules

  • Departhment of pharmacy,85th Hospital of PLA,Shanghai 200052,China
  • Received Date: 2010-01-15
  • Rev Recd Date: 2010-02-22

Abstract: Objective To prepare the andrographolide self-emulsifying drug delivery soft capsules(ASESC) and evaluate its quality. Methods The andrographolide self-emulsifying soft capsules were prepared.To screen the dissolution of andrographolide,the dissolution media and dissolution method of Ch.P were analysied.The dissolution of SMESC was measured,taking the commercial capsule as reference. Results The self-emulsifying drug delivery system was composed of ethyl oleate(10%),Tween 80(54%),n-Butanol(36%).The percent of accumulated dissolution of andrographolide in self-emulsifying drug delivery soft capsules in 0.2% SDS fluid was up to 70% at 45 min,which was far more than the commercial capsule. Conclusion The andrographolide self-emulsifying drug delivery capsules has been successfully prepared,and the dissolution of andrographolide was remarkably improved.

MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
Citation: MENG Hui, XU Yong. Study on preparation and dissolution of andrographolide self-emulsifying drug delivery soft capsules[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 184-185,208.
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