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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 199-200,205

LIU Hui-jun, CHEN Rui, WANG Juan. Determination of ephedrine and pseudoephedrine in Xuanfei Qingre mixture by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 199-200,205.
Citation: LIU Hui-jun, CHEN Rui, WANG Juan. Determination of ephedrine and pseudoephedrine in Xuanfei Qingre mixture by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 199-200,205.
shu

Determination of ephedrine and pseudoephedrine in Xuanfei Qingre mixture by HPLC

  • 1.

    Shanghai Songjiang Institute for Food and Drug Control,Shanghai 201600,China

  • 2.

    GuiYang College of Traditional Chinese Medicine,Guiyang 550001,China

  • Received Date: 2009-12-28
  • Rev Recd Date: 2010-03-09
  • Objective To set up a method of simultaneously determining the contents of ephedrine and pseudoephedrine in Xuanfei Qingre mixture(Herba Ephedrae,Semen Armeniacae amarum,Bulbus Fritillaria thunbergii,Radix scutellaria,etc). Methods The HPLC-quantitative analysis was carried out on a column of Agilent ZORBA× SB-CC18 by using a mobile phase of acetonitrile-0.02 mol/L potassium dihydrogen phosphate(adjusted with phosphoric acid pH=2.7),(4100,with 0.1% triethylamine)under a flow rate of 1.2 ml/min.207 nm was selected as the wavelength of detector. Results The linear range of ephedrine was 11.04～222.8 μg/ml(r=0.999 9)and pseudoephedrine's was 8.27～165.4 μg/ml(r=0.999 9).The recoveries of them were all between 95% and 105%(RSD<3%). Conclusion This method is simple,reproducible and specific.
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Determination of ephedrine and pseudoephedrine in Xuanfei Qingre mixture by HPLC

  • 1. Shanghai Songjiang Institute for Food and Drug Control,Shanghai 201600,China
  • 2. GuiYang College of Traditional Chinese Medicine,Guiyang 550001,China
  • Received Date: 2009-12-28
  • Rev Recd Date: 2010-03-09

Abstract: Objective To set up a method of simultaneously determining the contents of ephedrine and pseudoephedrine in Xuanfei Qingre mixture(Herba Ephedrae,Semen Armeniacae amarum,Bulbus Fritillaria thunbergii,Radix scutellaria,etc). Methods The HPLC-quantitative analysis was carried out on a column of Agilent ZORBA× SB-CC18 by using a mobile phase of acetonitrile-0.02 mol/L potassium dihydrogen phosphate(adjusted with phosphoric acid pH=2.7),(4100,with 0.1% triethylamine)under a flow rate of 1.2 ml/min.207 nm was selected as the wavelength of detector. Results The linear range of ephedrine was 11.04～222.8 μg/ml(r=0.999 9)and pseudoephedrine's was 8.27～165.4 μg/ml(r=0.999 9).The recoveries of them were all between 95% and 105%(RSD<3%). Conclusion This method is simple,reproducible and specific.

LIU Hui-jun, CHEN Rui, WANG Juan. Determination of ephedrine and pseudoephedrine in Xuanfei Qingre mixture by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 199-200,205.
Citation: LIU Hui-jun, CHEN Rui, WANG Juan. Determination of ephedrine and pseudoephedrine in Xuanfei Qingre mixture by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 199-200,205.
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