新型口服固体速释制剂———口腔速崩片
Rapidly-disintegrating tablet:a new solid dosage form
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摘要: 目的 介绍目前口腔速崩片崩解剂的特性、制备工艺、特点,为国内口崩片的设计和制备提供参考及思路。方法 概述了近十几年来,国外选用的崩解剂和改善口感的方法及其应用概况。结果 通过对口崩片崩解剂特性的了解,为口崩制剂的处方设计提供依据,开阔思路。结论 对口崩制剂的深入研究有助于开发有价值的老年人和其他特殊病人用药。Abstract: OBJECTIVE To introduce a new solid dosage form,a rapidly disintegrating tablet,which can be rapidly disintegrated and dissolved in the mouth within 15 second without drinking.METHODS Reviewed the relative articals in these years.RESULTS Among the articals,Low substituted hydroxypropylcellulose,microcrystalline cellulose and crosslinked sodium carboxymethyl cellulose or treated agar were used as disintegrants.Erythritol was selected to enhance palatability of the tablet.CONCLUSION It is necessary and practical to develop rapidly disintegrating tablet.
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Key words:
- rapidly disintegrating tablet /
- disintegrating agent /
- direct compression
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