125I-眼镜蛇神经毒素透鼻黏膜吸收及冰片的促进作用研究
Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol
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摘要: 目的 考察125I-(α-cobratoxin,Nt)透鼻黏膜吸收的情况及冰片的促进作用。方法 以大鼠、家兔、狗和羊为研究对象,以放射性活性(每分钟计数,count per minute,cpm)为指标,采用离体渗透鼻黏膜实验、在体渗透鼻黏膜重循环实验等方法,研究125I-Nt对不同动物透鼻黏膜吸收的情况及冰片的促进作用。结果 研究发现,Nt很难透过鼻黏膜吸收,但在冰片作用下吸收显著增加。结论 冰片对Nt透鼻黏膜吸收有显著促进作用。Abstract: Objective To determine the permeation profile of 125I-α-cobratoxin across different animals'nasal mucosa and the enhancement of borneol. Methods The rabbits、dogs and goats was selected as model animals, radioactivity (count per minute, cpm)as index, and a method called permeation of nasal mucosa in vitro was adopted,together with repeated cycle technique in situ to compare the permeation profile of Nt across different animals'nasal mucosa in vitro in order to confirm the permeation of these animals and the effect of borneol. Results Nt could penetrate the nasal mucosa of different animals and be absorbed, but the amount was low. However, the absorption could be enhanced under the help of borneol. Conclusion Borneol could enhance the absorption of Nt arcoss the nasal mucosa.
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Key words:
- α-cobratoxin /
- transmucosal-absorption /
- borneol
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