头孢噻肟钠与氧氟沙星注射液配伍的稳定性研究
Studies on compatible stability between cefotaxime sodium and oflaxacin injection
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摘要: 目的 研究头孢噻肟钠与氧氟沙星注射液配伍稳定性。方法 建立头孢噻肟钠与氧氟沙星混合液紫外分光光度法含量测定方法,分析混合液在24℃下8h内两药含量,并观察其外观、pH值及紫外光谱。结果 4h内混合液外观、pH值及紫外光谱无明显变化,6h后两药含量测定结果较4h偏高,8h后混合液紫外光谱发生改变。结论 在24℃下,头孢噻肟钠与氧氟沙星注射液配伍后4h内稳定性较好,临床上两药配伍使用应在4h内完成。Abstract: Objective To study the compatible stability between cefotaxime sodium and oflaxacin injection. Methods The UVmethod for determination of cefotaxime and ofloxacin in their mixed solution was established, by which they were assayed when the mixed solution was set at 24℃ during 8h. The appearance, pH values and UV spectrum of the mixed solution were also examined. Results The appearance, pH values and UV spectrum of the mixed solution didn't change obviously during 4h. The assay values for cefotaxime sodium and ofloxacin 6h late were higher than 4h. The UV spectrum of the mixed solution changed obviously 8h late. Conclusion They were stable when cefotaxime was dissolved in oflaxacin injection, suggesting oflaxacin injection containing cefotaxime should be used up within 4h.
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Key words:
- cefotaxime sodium /
- oflaxacin injection /
- compatible stability
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