中等取代度的羟丙基-β-环糊精对地塞米松的包埋特性研究
The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone
-
摘要: 目的: 研究中等取代度的羟丙基-β-环糊精合成工艺及其对难溶性药物地塞米松的包埋性能。 方法: 合成了中等取代度的羟丙基-β-环糊精,并按照药典相关规定对产品质量进行了检测。用该产品包合难溶性药物地塞米松,并用相溶解度法对包合物进行了研究。 结果: 合成了取代度为7.875的羟丙基-β-环糊精,产品与地塞米松形成了1:1的包合物,提高地塞米松的溶解度约33倍。 结论: 合成的羟丙基-β-环糊精符合药典要求;通过羟丙基-β-环糊精的包合,提高了地塞米松的水溶性。Abstract: Objective To investigate synthesis of medium substituted degree hydroxypropyl-β-cyclodextrins and the complex forming capability of dexamethasone. Methods Medium substituted degree hydroxypropyl-β-cyclodextrins were prepared and tested by pharmacopoeia.Dexamethasone were included with the product and performed by the phase-solubility diagram. Results The substituted degree of hydroxypropyl-β-cyclodextrins were 7.875.Dexamethasone was formed a 11 molar ratio inclusion complex with the product and improved solubility about 33 times. Conclusion The product accord with the request of pharmacopoeia.The dissolution capability of dexamethasone was increased by hydroxypropyl-β-cyclodextrins.
-
Key words:
- hydroxypropyl-β-cyclodextrins /
- substituted degree /
- complex forming /
- dexamethasone
计量
- 文章访问数: 2515
- HTML全文浏览量: 350
- PDF下载量: 831
- 被引次数: 0