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盐霉素纳米制剂的研究进展

朱冰,  盛丹丹,  李善心,  张黎

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文章导航 > 药学实践与服务  > 2016 >  34(6): 489-492,515
朱冰, 盛丹丹, 李善心, 张黎. 盐霉素纳米制剂的研究进展[J]. 药学实践与服务, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
引用本文: 朱冰, 盛丹丹, 李善心, 张黎. 盐霉素纳米制剂的研究进展[J]. 药学实践与服务, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
shu
ZHU Bing, SHENG Dandan, LI Shanxin, ZHANG Li. Advances in the nanotechnology-based drug delivery systems of salinomycin[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
Citation: ZHU Bing, SHENG Dandan, LI Shanxin, ZHANG Li. Advances in the nanotechnology-based drug delivery systems of salinomycin[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
shu

盐霉素纳米制剂的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.003
  • 1.

    第二军医大学附属长海医院药学部, 上海 200433;解放军96263部队医院药房, 河南 洛阳 471500

  • 2.

    第二军医大学附属长海医院药学部, 上海 200433

Advances in the nanotechnology-based drug delivery systems of salinomycin

  • 1.

    Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Department of Pharmacy, Hospital of No. 96263 Unit of PLA, Luoyang 471500, China

  • 2.

    Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

  • 摘要: 盐霉素（salinomycin，SAL）作为一种抗生素，已广泛用于畜牧业，近年来研究人员发现该药对多种肿瘤及肿瘤干细胞具有较强的抑制作用，而且体内外研究及早期临床试验结果均表明SAL具有抗肿瘤多重耐药活性，有望成为一种新型的抗肿瘤药物。但是，SAL的水溶性较差，且有一定的毒副作用，为获得更好的治疗效果，SAL制剂学的研究得到药学界的广泛关注。本文对近年来SAL纳米制剂的研究进展进行综述。
    Abstract: Salinomycin, extensively used as an antibiotic in animal husbandry for a long time, has recently been found to possess strong anti-cancer and anti-cancer stem cell efficacy, as well as activities to overcome multi-drug resistance of tumor based on studies in vivo and in vitro in case reports in pilot clinical trials. Therefore, salinomycin promised to be a novel anti-cancer agent. However, the unfavorable property of poor aqueous solubility and the adverse effects of salinomycin were greatly hinder its clinical use. In order to improve its therapeutic index and alleviate its toxicity, studies on nanotechnology-based delivery systems of salinomycin had been widely conducted. In this article, the latest development and application of salinomycin nanoformulations were reviewed.
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    [2] Wang Y. Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells[J]. Med Chem, 2011, 7(2):106-111.
    [3] Dong TT, Zhou HM, Wang LL, et al. Salinomycin selectively targets CD133+ cell subpopulations and decreases malignant traits in colorectal cancer lines[J]. Ann Surg Oncol, 2011, 18(6):1797-1804.
    [4] Kim WK, Kim JH, Yoon K, et al. Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest[J]. Invest New Drugs, 2012, 30(4):1311-1318.
    [5] Huczynski A. Salinomycin:a new cancer drug candidate[J]. Chem Biol Drug Des, 2012, 79(3):235-238.
    [6] Ojo OO, Bhadauria S, Rath SK. Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice[J]. Plos One, 2013, 8(7):e69086.
    [7] Barenholz Y. Doxil-the first FDA-approved nano-drug:lessons learned[J]. J Control Release, 2012, 160(2):117-134.
    [8] 巩志荣,何文婷,孙治国,等. 盐霉素钠纳米脂质体的制备及表征[J]. 药学实践杂志, 2015, 33(1):36-39.
    [9] Momekova D, Momekov G, Ivanova J, et al. Sterically stabilized liposomes as a platform for salinomycin metal coordination compounds:physicochemical characterization and in vitro evaluation[J]. J Drug Deliv Sci Technol, 2013, 23(3):215-223.
    [10] Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics:an emerging treatment modality for cancer[J]. Nat Rev Drug Discov, 2008, 7(9):771-782.
    [11] Ni M, Xiong M, Zhang X, et al. Poly (lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells[J]. Int J Nanomedicine, 2015, 10:2537-2554.
    [12] Jiang J, Chen H, Yu C, et al. The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles[J]. Nanomedicine, 2015, 10(12):1863-1879.
    [13] Zhao P, Dong S, Bhattacharyya J, et al. iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors[J]. Mol Pharm, 2014, 11(8):2703-2712.
    [14] Wang Q, Wu P, Ren W, et al. Comparative studies of salinomycin-loaded nanoparticles prepared by nanoprecipitation and single emulsion method[J]. Nanoscale Res Lett, 2014, 9(1):351-359.
    [15] Aydin RS. Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting[J]. J Biomed Mater Res A, 2013, 101(5):1405-1415.
    [16] Lei Y, Lai Y,Li Y, et al. Anticancer drug delivery of PEG based micelles with small lipophilic moieties[J]. Int J Pharm, 2013, 453(2):579-586.
    [17] 毛骁丽, 张翮, 俞媛,等. 穿膜肽修饰盐霉素胶束的制备与表征[J]. 中国新药杂志, 2014, 23(23):2812-2816.
    [18] Wei T, Liu J, Ma H, et al. Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo[J]. Nano Letters, 2013, 13(6):2528-2534.
    [19] 张杨, 代文兵, 王坚成,等. 载盐霉素聚合物胶束的构建与抗肿瘤干细胞的体外研究[J]. 中国药学杂志, 2014, 49(5):384-391.
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    [21] Zhang Y, Zhang H, Wang X, et al. The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles[J]. Biomaterials, 2012, 33(2):679-691.
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  • 收稿日期:  2016-03-03
  • 修回日期:  2016-05-24

盐霉素纳米制剂的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.003
  • 1. 第二军医大学附属长海医院药学部, 上海 200433;解放军96263部队医院药房, 河南 洛阳 471500
  • 2. 第二军医大学附属长海医院药学部, 上海 200433
  • 收稿日期: 2016-03-03
  • 修回日期: 2016-05-24

摘要: 盐霉素（salinomycin，SAL）作为一种抗生素，已广泛用于畜牧业，近年来研究人员发现该药对多种肿瘤及肿瘤干细胞具有较强的抑制作用，而且体内外研究及早期临床试验结果均表明SAL具有抗肿瘤多重耐药活性，有望成为一种新型的抗肿瘤药物。但是，SAL的水溶性较差，且有一定的毒副作用，为获得更好的治疗效果，SAL制剂学的研究得到药学界的广泛关注。本文对近年来SAL纳米制剂的研究进展进行综述。

English Abstract

朱冰, 盛丹丹, 李善心, 张黎. 盐霉素纳米制剂的研究进展[J]. 药学实践与服务, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
引用本文: 朱冰, 盛丹丹, 李善心, 张黎. 盐霉素纳米制剂的研究进展[J]. 药学实践与服务, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
shu
ZHU Bing, SHENG Dandan, LI Shanxin, ZHANG Li. Advances in the nanotechnology-based drug delivery systems of salinomycin[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
Citation: ZHU Bing, SHENG Dandan, LI Shanxin, ZHANG Li. Advances in the nanotechnology-based drug delivery systems of salinomycin[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
shu

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