Progress on anti-HBV constituents from traditional Chinese medicine

JIN Qian-xing; ZHOU Feng

doi:10.3969/j.issn.1006-0111.2012.02.005

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2012 > 30(2): 96-99,148

JIN Qian-xing, ZHOU Feng. Progress on anti-HBV constituents from traditional Chinese medicine[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 96-99,148. doi: 10.3969/j.issn.1006-0111.2012.02.005

Citation:

JIN Qian-xing, ZHOU Feng. Progress on anti-HBV constituents from traditional Chinese medicine[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 96-99,148. doi: 10.3969/j.issn.1006-0111.2012.02.005

Progress on anti-HBV constituents from traditional Chinese medicine

doi: 10.3969/j.issn.1006-0111.2012.02.005

JIN Qian-xing¹,
ZHOU Feng²

1.
Traditional medicine hospital of zhejiang province, Hangzhou 310006, China;School of pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China
2.
Traditional medicine hospital of zhejiang province, Hangzhou 310006, China

Received Date: 2011-10-26
Rev Recd Date: 2012-02-15

Abstract

Objective To introduce advances of anti-HBV bioactive substances from traditional Chinese medicine. Methods Anti-HBV constituents from traditional Chinese medicine research were reviewed, which were focused on the saponins, alkaloids, flavones and polysaccharides. Results and Conclusions Traditional Chinese medicine had been demonstrated as the potent anti-HBV bioactive substances, which was the important approach to the treatment of HBV.
- hepatitis B virus,
- traditional Chinese medicine,
- constituents

References

[1]	贺浪冲,岐琳.陕西叶下珠药用开发研究Ⅲ:提取物体外灭活HBV抗原作用[J].西北药学杂志,1996,11(1):11.
[2]	郑民实,陈永康.ELISA技术检测中草药抗HBsAg[J].中西医结合杂志, 1990,10(9):560.
[3]	张正,许向东,杜绍财,等.60种中草药抗乙型肝炎病毒的实验研究[J].北京医科大学学报, 1988,20(3):23l.
[4]	郑民实,邱健辉.使用ELISA技术检测中草药抗HBeAg的实验研究[J].天然产物研究与开发,1995,7(1):10.
[5]	宋星宏.甘草甜素治疗慢性乙肝疗效观察[J].中国中西医结合杂志,1997,17(8):494.
[6]	Liu H,Wei W, Sun WY, et al. Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats in vitro effects on Hepatic stellate cells[J].J ethnophamacol, 2009,122(3):502.
[7]	张娟,陈建宗,张金平,等.黄芪甲苷体外抗乙型肝炎病毒的作用[J].第四军医大学学报,2007,24:2291.
[8]	周艳萌,吴中明.土贝母皂苷对HBV转染的HepG2 2.2.15细胞分泌HBsAg和HBeAg的抑制作用[J].遵义医学院学报,2005,28(02):112.
[9]	周艳萌,吴中明,向晓波,等.土贝母皂苷体内抗乙型肝炎病毒的实验研究[J].遵义医学院学报,2007,30(03):232.
[10]	林兴,黄权芳,张士军,等.六月青总皂苷对HepG2.2.15细胞HBV复制的抑制作用[J].时珍国医国药,2009,20(11):2728.
[11]	蒋蔚峰,陈建宗,张娟,等.荔枝核总皂苷体外抗乙型肝炎病毒的作用[J].第四军医大学学报,2008,29(2):100.
[12]	赵英仁,李兴,张树林,等.绞股蓝总皂苷治疗慢性乙肝及其机制的体内外研究[J].陕西中医学院学报,1997,20(4):31.
[13]	Zembower DE,Lin YM, Flavin MT,et al.Robustaflavone,a potential non-nucleoside anti-hepatitis B agent[J]. Antiviral Res,1998.39(2):81.
[14]	Guo Q, Zhao L, You Q, et al. Anti-hepatitis B virus activity of wogonin in virtro and in vivo[J]. Antiviral Res, 2007,74(1):16.
[15]	Huang RL, Chen CC, Huang HL, et al. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis[J]. Planta Med, 2000, 66(8): 694.
[16]	杨国红.瑞香狼毒等三种药用植物的生物活性成分[D].复旦大学博士学位论文, 2005,81.
[17]	郑作文,邓家刚,杨柯.芒果苷在2215细胞培养中对乙肝病毒HBsAg、HBeAg分泌的影响[J].中医药学刊,2004,22(9):1645.
[18]	邓家刚,邓静,周文强,等.芒果苷对HepG2.2.15细胞β-arrestins信号通路影响的研究[J]. 中药药理与临床,2011,2(2):22.
[19]	Wang WN, Yang XB, Liu HZ, et al. Effects of Oenanthe javanica flavone on human and duck hepatitis B virus infection[J]. Acta pharmacol Sin, 2005,26(5):587.
[20]	徐庆,宋芸娟,陈全斌,等.荔枝核黄酮类化合物对HepG2.2.15细胞系HBsAg与HBeAg表达及HBV-DNA含量的影响[J].第四军医大学学报,2004,24(7):1862.
[21]	徐庆,宋芸娟,李丽亚,等.荔枝核总黄酮的抗鸭乙型肝炎病毒作用[J].世界华人消化杂志,2005,13(17):2082.
[22]	黄绍军,黄秋玲,义祥辉,等.荔枝叶的化学成分研究[J].中草药,2007,38(9):1313.
[23]	饶肾高,肖伟烈,杨柳萌,等. 狭叶五味子中化合物扁枝杉香豆素和(-)-表儿茶酸体外抗乙型肝炎病毒活性研究[J]. 中草药,2009,40(2):248.
[24]	蔡雄,王国俊,瞿瑶,等.苦参碱注射液治疗慢性乙型肝炎临床疗效分析[J].第二军医大学学报, 1997,18(1):47.
[25]	徐文胜,王国俊,缪晓辉,等.氧化苦参碱HepG2.2.15细胞中乙型肝炎病毒DNA表达量的影响[J].第二军医大学学报,2002,23(1):72.
[26]	许斌,周双残,黄玉仙,等.氧化苦参碱在鸭原代肝细胞中抗鸭乙肝病毒(DHBV)作用的研究[J].病毒学报,2006,22(5):369.
[27]	聂红明,陈建杰,高月求,等.槐定碱体外抗乙肝病毒的实验研究[J].北京中医,2007,26(10):678.
[28]	聂红明,王灵台,陈建杰,等.槐果碱体外对HepG2.2.15细胞分泌HBsAg HBeAg的影响[J].辽宁中医杂志,2006,33(11):1478.
[29]	何玉先,徐克沂,张启云,等.汉防己对大鼠实验性肝纤维胶原蛋白合成的抑制作用[J].中国中药杂志,1996,21(3):177.
[30]	Romero MR,Efferth T,Serrano MA,et al.Effect of artemisinin artesunate as inhibitors of hepatitis B virus production in an in vitro replicative system[J].Antiviral Res,2005,68(2):75.
[31]	Li HL, Han T, Liu RH, et al.Alkaloids from Corydalis saxicola and their anti-hepatitis B virus activity[J].Chem Biodivers, 2008,5 (5):777.
[32]	白鹄,梅存金.胸腺肽联合猪苓多糖及乙肝疫苗治疗慢性乙型肝炎疗效观察[J].河北医学,1999,5(3):20.
[33]	盛剑秋,杨淑英,段芳龄,等.香菇多糖的免疫调节作用研究进展[J].胃肠学和肝病学杂志,1998,7(1):92.
[34]	黄永森,逢金聚,王有义,等.藻酸双酯钠联合病毒唑病毒和香菇多糖分段治疗慢性乙肝与其它几种疗法的比较[J].中国现代医学杂志,1998,8(1):41.
[35]	郑敏,卢葵花,吴基良,等.大蒜多糖体外抗乙型肝炎病毒作用研究[J].中药药理与临床,2005,21(3):29.
[36]	黄键,陈必链,游文朗.紫球藻胞外多糖的分离及体外抗乙肝病毒活性的初步研究[J].中国海洋药物,2005,24(5):18.
[37]	岑颖洲, 马夏军, 王凌云,等.羊栖菜多糖的制备及其对HepG2细胞的抑制作用[J].中国海洋药物,2005,24(1):21.
[38]	张玉,蒋小丰,张名洋,等.山豆根多糖硫酸化修饰及其体外抗HBV活性测定[J].中国临床药学杂志,2011,20(3):151.
[39]	郑民实,孔庚星,张鑫,等.没食子酸抗HBsAg／HBeAg的实验研究[J].实用中医药杂志,1998, 14(1):5.
[40]	Geng CA, Jiang ZY, Ma YB, et al. Swerilactones A and B, anti-HBV new lactones from a tradtional Chinese herb: Swertia mileensis as a treatment for viral hepatitis[J].Org Lett,2009,11(18):4120.
[41]	Yang LB, Li L, Huang SX. et al. Anti-hepatitis B virus and cytotoxic diterpenoids from var. Gerardianus[J]. Chem Pharm Bull,2011, 59 (9):1102.
[42]	Geng CA, Wang LJ, Zhang XM, et al.Anti-hepatitis b virus active lactones from the traditional chinese herb: Swertia mileensis[J].Chemistry-A European Journal,2011,17 (14):3893.
[43]	Cui X, Inagaki, Y, Xu H, et al. Anti-hepatitis B virus activities of cinobufacini and its active components bufalin and cinobufagin in HepG2.2.15 Cells[J].Biol Pharm Bull, 2010,33(10):1728.
[44]	徐向男,荆培棠,李永华,等.华蟾素治疗慢性活动性乙肝临床疗效观察[J].中国中西医结合杂志,1993,13(8):473.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Progress on anti-HBV constituents from traditional Chinese medicine

1. Traditional medicine hospital of zhejiang province, Hangzhou 310006, China;School of pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China

2. Traditional medicine hospital of zhejiang province, Hangzhou 310006, China

Received Date: 2011-10-26

Rev Recd Date: 2012-02-15

Key words:

Abstract: Objective To introduce advances of anti-HBV bioactive substances from traditional Chinese medicine. Methods Anti-HBV constituents from traditional Chinese medicine research were reviewed, which were focused on the saponins, alkaloids, flavones and polysaccharides. Results and Conclusions Traditional Chinese medicine had been demonstrated as the potent anti-HBV bioactive substances, which was the important approach to the treatment of HBV.

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Reference (44)

[1]	贺浪冲,岐琳.陕西叶下珠药用开发研究Ⅲ:提取物体外灭活HBV抗原作用[J].西北药学杂志,1996,11(1):11.
[2]	郑民实,陈永康.ELISA技术检测中草药抗HBsAg[J].中西医结合杂志, 1990,10(9):560.
[3]	张正,许向东,杜绍财,等.60种中草药抗乙型肝炎病毒的实验研究[J].北京医科大学学报, 1988,20(3):23l.
[4]	郑民实,邱健辉.使用ELISA技术检测中草药抗HBeAg的实验研究[J].天然产物研究与开发,1995,7(1):10.
[5]	宋星宏.甘草甜素治疗慢性乙肝疗效观察[J].中国中西医结合杂志,1997,17(8):494.
[6]	Liu H,Wei W, Sun WY, et al. Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats in vitro effects on Hepatic stellate cells[J].J ethnophamacol, 2009,122(3):502.
[7]	张娟,陈建宗,张金平,等.黄芪甲苷体外抗乙型肝炎病毒的作用[J].第四军医大学学报,2007,24:2291.
[8]	周艳萌,吴中明.土贝母皂苷对HBV转染的HepG2 2.2.15细胞分泌HBsAg和HBeAg的抑制作用[J].遵义医学院学报,2005,28(02):112.
[9]	周艳萌,吴中明,向晓波,等.土贝母皂苷体内抗乙型肝炎病毒的实验研究[J].遵义医学院学报,2007,30(03):232.
[10]	林兴,黄权芳,张士军,等.六月青总皂苷对HepG2.2.15细胞HBV复制的抑制作用[J].时珍国医国药,2009,20(11):2728.
[11]	蒋蔚峰,陈建宗,张娟,等.荔枝核总皂苷体外抗乙型肝炎病毒的作用[J].第四军医大学学报,2008,29(2):100.
[12]	赵英仁,李兴,张树林,等.绞股蓝总皂苷治疗慢性乙肝及其机制的体内外研究[J].陕西中医学院学报,1997,20(4):31.
[13]	Zembower DE,Lin YM, Flavin MT,et al.Robustaflavone,a potential non-nucleoside anti-hepatitis B agent[J]. Antiviral Res,1998.39(2):81.
[14]	Guo Q, Zhao L, You Q, et al. Anti-hepatitis B virus activity of wogonin in virtro and in vivo[J]. Antiviral Res, 2007,74(1):16.
[15]	Huang RL, Chen CC, Huang HL, et al. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis[J]. Planta Med, 2000, 66(8): 694.
[16]	杨国红.瑞香狼毒等三种药用植物的生物活性成分[D].复旦大学博士学位论文, 2005,81.
[17]	郑作文,邓家刚,杨柯.芒果苷在2215细胞培养中对乙肝病毒HBsAg、HBeAg分泌的影响[J].中医药学刊,2004,22(9):1645.
[18]	邓家刚,邓静,周文强,等.芒果苷对HepG2.2.15细胞β-arrestins信号通路影响的研究[J]. 中药药理与临床,2011,2(2):22.
[19]	Wang WN, Yang XB, Liu HZ, et al. Effects of Oenanthe javanica flavone on human and duck hepatitis B virus infection[J]. Acta pharmacol Sin, 2005,26(5):587.
[20]	徐庆,宋芸娟,陈全斌,等.荔枝核黄酮类化合物对HepG2.2.15细胞系HBsAg与HBeAg表达及HBV-DNA含量的影响[J].第四军医大学学报,2004,24(7):1862.
[21]	徐庆,宋芸娟,李丽亚,等.荔枝核总黄酮的抗鸭乙型肝炎病毒作用[J].世界华人消化杂志,2005,13(17):2082.
[22]	黄绍军,黄秋玲,义祥辉,等.荔枝叶的化学成分研究[J].中草药,2007,38(9):1313.
[23]	饶肾高,肖伟烈,杨柳萌,等. 狭叶五味子中化合物扁枝杉香豆素和(-)-表儿茶酸体外抗乙型肝炎病毒活性研究[J]. 中草药,2009,40(2):248.
[24]	蔡雄,王国俊,瞿瑶,等.苦参碱注射液治疗慢性乙型肝炎临床疗效分析[J].第二军医大学学报, 1997,18(1):47.
[25]	徐文胜,王国俊,缪晓辉,等.氧化苦参碱HepG2.2.15细胞中乙型肝炎病毒DNA表达量的影响[J].第二军医大学学报,2002,23(1):72.
[26]	许斌,周双残,黄玉仙,等.氧化苦参碱在鸭原代肝细胞中抗鸭乙肝病毒(DHBV)作用的研究[J].病毒学报,2006,22(5):369.
[27]	聂红明,陈建杰,高月求,等.槐定碱体外抗乙肝病毒的实验研究[J].北京中医,2007,26(10):678.
[28]	聂红明,王灵台,陈建杰,等.槐果碱体外对HepG2.2.15细胞分泌HBsAg HBeAg的影响[J].辽宁中医杂志,2006,33(11):1478.
[29]	何玉先,徐克沂,张启云,等.汉防己对大鼠实验性肝纤维胶原蛋白合成的抑制作用[J].中国中药杂志,1996,21(3):177.
[30]	Romero MR,Efferth T,Serrano MA,et al.Effect of artemisinin artesunate as inhibitors of hepatitis B virus production in an in vitro replicative system[J].Antiviral Res,2005,68(2):75.
[31]	Li HL, Han T, Liu RH, et al.Alkaloids from Corydalis saxicola and their anti-hepatitis B virus activity[J].Chem Biodivers, 2008,5 (5):777.
[32]	白鹄,梅存金.胸腺肽联合猪苓多糖及乙肝疫苗治疗慢性乙型肝炎疗效观察[J].河北医学,1999,5(3):20.
[33]	盛剑秋,杨淑英,段芳龄,等.香菇多糖的免疫调节作用研究进展[J].胃肠学和肝病学杂志,1998,7(1):92.
[34]	黄永森,逢金聚,王有义,等.藻酸双酯钠联合病毒唑病毒和香菇多糖分段治疗慢性乙肝与其它几种疗法的比较[J].中国现代医学杂志,1998,8(1):41.
[35]	郑敏,卢葵花,吴基良,等.大蒜多糖体外抗乙型肝炎病毒作用研究[J].中药药理与临床,2005,21(3):29.
[36]	黄键,陈必链,游文朗.紫球藻胞外多糖的分离及体外抗乙肝病毒活性的初步研究[J].中国海洋药物,2005,24(5):18.
[37]	岑颖洲, 马夏军, 王凌云,等.羊栖菜多糖的制备及其对HepG2细胞的抑制作用[J].中国海洋药物,2005,24(1):21.
[38]	张玉,蒋小丰,张名洋,等.山豆根多糖硫酸化修饰及其体外抗HBV活性测定[J].中国临床药学杂志,2011,20(3):151.
[39]	郑民实,孔庚星,张鑫,等.没食子酸抗HBsAg／HBeAg的实验研究[J].实用中医药杂志,1998, 14(1):5.
[40]	Geng CA, Jiang ZY, Ma YB, et al. Swerilactones A and B, anti-HBV new lactones from a tradtional Chinese herb: Swertia mileensis as a treatment for viral hepatitis[J].Org Lett,2009,11(18):4120.
[41]	Yang LB, Li L, Huang SX. et al. Anti-hepatitis B virus and cytotoxic diterpenoids from var. Gerardianus[J]. Chem Pharm Bull,2011, 59 (9):1102.
[42]	Geng CA, Wang LJ, Zhang XM, et al.Anti-hepatitis b virus active lactones from the traditional chinese herb: Swertia mileensis[J].Chemistry-A European Journal,2011,17 (14):3893.
[43]	Cui X, Inagaki, Y, Xu H, et al. Anti-hepatitis B virus activities of cinobufacini and its active components bufalin and cinobufagin in HepG2.2.15 Cells[J].Biol Pharm Bull, 2010,33(10):1728.
[44]	徐向男,荆培棠,李永华,等.华蟾素治疗慢性活动性乙肝临床疗效观察[J].中国中西医结合杂志,1993,13(8):473.

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Progress on anti-HBV constituents from traditional Chinese medicine

doi: 10.3969/j.issn.1006-0111.2012.02.005

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References

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通讯作者: 陈斌, bchen63@163.com

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