Advance in drug therapy of gout

XU Na; CHEN Hai-sheng

doi:10.3969/j.issn.1006-0111.2013.01.004

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Volume 31 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2013 > 31(1): 14-18

XU Na, CHEN Hai-sheng. Advance in drug therapy of gout[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 14-18. doi: 10.3969/j.issn.1006-0111.2013.01.004

Citation:

XU Na, CHEN Hai-sheng. Advance in drug therapy of gout[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 14-18. doi: 10.3969/j.issn.1006-0111.2013.01.004

Advance in drug therapy of gout

doi: 10.3969/j.issn.1006-0111.2013.01.004

Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-02-09
Rev Recd Date: 2012-05-21

Abstract

With the development of the living standard, the incidence of gout was rising and the trend of patient age with gout getting younger. Developing high-effective and low-adverse anti-gout drugs was a priority of the research agenda. At present, conventional therapies of gout lean on western medicines. These drugs relieved or treated gout with different mechanisms, but all of them had different side-effects. Recently, more and more researchers started to develop traditional Chinese medicine to treat gout and their effectiveness and the side-effects need further clinical verification. The commonly used anti-gout drugs or new drugs under research including their treatment characteristics, potential hazards and their therapeutic principles at different clinical stages were summarized in this article, especially in some anti-hyperuricemia or anti-gout Chinese Medicine, which gave an effective way to develop new anti-gout drugs.
- gout,
- anti-gout drugs,
- advance therapeutics,
- Chinese Medicine

References

[1]	Hayden MR, Tyagi SC. Uric acid: a new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type diabetes mellitus: the urate redox shuttle[J]. Nutr Metab(Lond), 2004, 1 (1):10.
[2]	Miao Z, Li CG, Chen Y, et al. Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of eastern China[J]. J Rheumatol, 2008, 35 (9):1859.
[3]	江瀛,徐领城. 痛风的药物治疗进展[J]. 海峡药学, 2010, 22 (1):100.
[4]	Howard SS, Donna BY, Joshua MS. Gout: Current Insights and Future Perspectives[J]. Journal of Pain, 2011, 12 (11):1113.
[5]	Emmerson BT. The management of gout[J]. Clinical Biochemistry, 1997, 30 (3):253.
[6]	Miguelez R, Palacios L, Navarru F, et al. Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antipreteinase activity in an experimental model of acute urate crystal arthritis[J]. Lipid Mediat Cell Sisn, 1996, 13 (1):35.
[7]	Tausche AK, Richter K, Giassler A, et al. Severe gouty arthriti refractory to anti-inflammatory drugs:treatment with anti-tumouneerosis actor alpha as a new therapeutic option[J]. Ann Rheum Dis, 2004, 63 (10):1351.
[8]	Schumacher HR, Sundy JS, Terke LR, et al. Placebo controlled study of rilonacept for gout flare prophylaxis during initiation of urate lowering therapy[J]. Arthritis Rheum, 2009, 60 (4): 410
[9]	So A, Meulemeester MD, Pikhlak A, et al. Canakinumab for the treatment of acute flares in difficult-to-reat gouty arthritis: Results of a multicenter, phase II, dose-ranging study[J]. Arthritis Rheum, 2010, 62(10): 3064.
[10]	Singh D, Huston KK. IL-1 inhibition with anakinra in a patient with refractory gout[J]. J Clin Rheumatol, 2009, 15(7):366.
[11]	朱深银,周远大,杜冠华.防治痛风药物的研究进展[J].医药导报,2006,25(8):803.
[12]	Takano Y, Haze-Aoki K, Horiuchi H, et al. Selectivity of febuxostat, anovel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase[J]. Life sci, 2005, 76: 1835.
[13]	Burns CM, Wortmann RL. Gout therapeutics: new drugs for an old disease[J]. New Drug Class, 2011, 377:165.
[14]	Mohamed DA, Al-Okbi SY. Evaluation of anti-gout activity of some plant food extracts[J]. Polish Journal Of Food and Nut, 2008, 58 (3):389.
[15]	Tian YQ, Kou JP, Li LZ, et al. Anti-inflammatory effect of aqueous extract from Radix Liriope muscari and its major active fraction and component[J]. Chinese Journal of Natural Medicines, 2011, 9 (3):0222.
[16]	姚佳,曹晓燕,王结之. 6种秦艽镇痛和抗炎活性的比较[J].现代生物医学进展, 2010, 10(24):4642.
[17]	廉莲,贾天.黄柏及其炮制品的抗痛风作用研究[J].安徽农业科学, 2011,39(15): 8911.
[18]	Kong LD, Yang C, Ge F. et al. A Chinese herbal medicine Ermiao wall reduces serum uric acid level and inhibits liver xanthine dehydmgene and xanthine oxidase in mice[J]. J Ethnopharmaco1, 2004, 93 (23):325.
[19]	Powanda MC, Rainsford KD. A toxicological investigation of a celery seed extract having anti-inflammatory activity[J]. Inflammopharmacology, 2010, 19 (4):227.
[20]	仝国辉,张懿,张瑶楠. 芹菜籽提取物对高尿酸血症大鼠的影响[J]. 食品科学, 2008, 29 (6):641.
[21]	Ahamd NS, Farmn M, Najmi MH, et al. Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout[J]. J Ethnopharmacol, 2008,117 (3):478.
[22]	Umamaheswari M, Asokkuar K, Sivashanmugam AT, et al. In vitro xanthine oxidase inhibitory activity of the fractions of Erythrina stricta roxb[J]. J Ethnopharmacol, 2009, 124(3): 646.
[23]	Murugaiyah V, Chan KL. Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents[J]. J Ethnopharmacol, 2009, 124 (2):233.
[24]	Chien SC, Yang CW, Tseng YH, et al. Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice[J]. Planta Med, 2009,75 (4):302.
[25]	Maitraie D, Hung CF, Tu HY, et al. Synthesis, anti-inflammatory and antioxidant activities of 18B-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors[J]. Bioorg Med Chem,2009,17 (7):2785.
[26]	Wang Y, Zhu JX, Kong LD, et al. Administration of procyanidins from grape seecls reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice[J]. Basic Clin Pharmacology & Toxicology, 2004, 94 (5):232.
[27]	Zhu JX, WangY, Kong LD, et al. Effects of Biota orientalis extract and its flavonoid constituents quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver[J].J Ethnopharmacol, 2004, 93 (1): 133.
[28]	Yoshizumi K, Nishioka N, Tsuji T. Xanthine oxidase inhibitory activity and hyypouricemia effect of propolis in rats[J]. Journal of the Pharmaceutical Society of Japan, 2005, 125 (3):315.
[29]	Lin HC, Tsai SH, Chen CS, et al. Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities[J]. Biochem Pharmacol,2008, 75: 1416.
[30]	Odontuya GJ, Hoult RS, Houghton PJ. Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides[J]. Phytother Res, 2005, 19, 782.
[31]	薛莎,朱琼洁,马威. 伸秦组方对高尿酸血症小鼠的影响[J].中国药物经济学,2010, 2:87.
[32]	杨和金,苏梅,赵春梅,等. 痛风液抗痛风性关节炎的实验研究[J].中草药, 2010, 9 (41):1504.
[33]	陈海生,乔丽名,刘建国,等. 芹菜籽黄酮类和香豆素类化合物在制备防治痛风药物的用途,中国发明专利 ZL 200710062800.6.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Advance in drug therapy of gout

Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-02-09

Rev Recd Date: 2012-05-21

Key words:

Abstract: With the development of the living standard, the incidence of gout was rising and the trend of patient age with gout getting younger. Developing high-effective and low-adverse anti-gout drugs was a priority of the research agenda. At present, conventional therapies of gout lean on western medicines. These drugs relieved or treated gout with different mechanisms, but all of them had different side-effects. Recently, more and more researchers started to develop traditional Chinese medicine to treat gout and their effectiveness and the side-effects need further clinical verification. The commonly used anti-gout drugs or new drugs under research including their treatment characteristics, potential hazards and their therapeutic principles at different clinical stages were summarized in this article, especially in some anti-hyperuricemia or anti-gout Chinese Medicine, which gave an effective way to develop new anti-gout drugs.

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Reference (33)

[1]	Hayden MR, Tyagi SC. Uric acid: a new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type diabetes mellitus: the urate redox shuttle[J]. Nutr Metab(Lond), 2004, 1 (1):10.
[2]	Miao Z, Li CG, Chen Y, et al. Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of eastern China[J]. J Rheumatol, 2008, 35 (9):1859.
[3]	江瀛,徐领城. 痛风的药物治疗进展[J]. 海峡药学, 2010, 22 (1):100.
[4]	Howard SS, Donna BY, Joshua MS. Gout: Current Insights and Future Perspectives[J]. Journal of Pain, 2011, 12 (11):1113.
[5]	Emmerson BT. The management of gout[J]. Clinical Biochemistry, 1997, 30 (3):253.
[6]	Miguelez R, Palacios L, Navarru F, et al. Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antipreteinase activity in an experimental model of acute urate crystal arthritis[J]. Lipid Mediat Cell Sisn, 1996, 13 (1):35.
[7]	Tausche AK, Richter K, Giassler A, et al. Severe gouty arthriti refractory to anti-inflammatory drugs:treatment with anti-tumouneerosis actor alpha as a new therapeutic option[J]. Ann Rheum Dis, 2004, 63 (10):1351.
[8]	Schumacher HR, Sundy JS, Terke LR, et al. Placebo controlled study of rilonacept for gout flare prophylaxis during initiation of urate lowering therapy[J]. Arthritis Rheum, 2009, 60 (4): 410
[9]	So A, Meulemeester MD, Pikhlak A, et al. Canakinumab for the treatment of acute flares in difficult-to-reat gouty arthritis: Results of a multicenter, phase II, dose-ranging study[J]. Arthritis Rheum, 2010, 62(10): 3064.
[10]	Singh D, Huston KK. IL-1 inhibition with anakinra in a patient with refractory gout[J]. J Clin Rheumatol, 2009, 15(7):366.
[11]	朱深银,周远大,杜冠华.防治痛风药物的研究进展[J].医药导报,2006,25(8):803.
[12]	Takano Y, Haze-Aoki K, Horiuchi H, et al. Selectivity of febuxostat, anovel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase[J]. Life sci, 2005, 76: 1835.
[13]	Burns CM, Wortmann RL. Gout therapeutics: new drugs for an old disease[J]. New Drug Class, 2011, 377:165.
[14]	Mohamed DA, Al-Okbi SY. Evaluation of anti-gout activity of some plant food extracts[J]. Polish Journal Of Food and Nut, 2008, 58 (3):389.
[15]	Tian YQ, Kou JP, Li LZ, et al. Anti-inflammatory effect of aqueous extract from Radix Liriope muscari and its major active fraction and component[J]. Chinese Journal of Natural Medicines, 2011, 9 (3):0222.
[16]	姚佳,曹晓燕,王结之. 6种秦艽镇痛和抗炎活性的比较[J].现代生物医学进展, 2010, 10(24):4642.
[17]	廉莲,贾天.黄柏及其炮制品的抗痛风作用研究[J].安徽农业科学, 2011,39(15): 8911.
[18]	Kong LD, Yang C, Ge F. et al. A Chinese herbal medicine Ermiao wall reduces serum uric acid level and inhibits liver xanthine dehydmgene and xanthine oxidase in mice[J]. J Ethnopharmaco1, 2004, 93 (23):325.
[19]	Powanda MC, Rainsford KD. A toxicological investigation of a celery seed extract having anti-inflammatory activity[J]. Inflammopharmacology, 2010, 19 (4):227.
[20]	仝国辉,张懿,张瑶楠. 芹菜籽提取物对高尿酸血症大鼠的影响[J]. 食品科学, 2008, 29 (6):641.
[21]	Ahamd NS, Farmn M, Najmi MH, et al. Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout[J]. J Ethnopharmacol, 2008,117 (3):478.
[22]	Umamaheswari M, Asokkuar K, Sivashanmugam AT, et al. In vitro xanthine oxidase inhibitory activity of the fractions of Erythrina stricta roxb[J]. J Ethnopharmacol, 2009, 124(3): 646.
[23]	Murugaiyah V, Chan KL. Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents[J]. J Ethnopharmacol, 2009, 124 (2):233.
[24]	Chien SC, Yang CW, Tseng YH, et al. Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice[J]. Planta Med, 2009,75 (4):302.
[25]	Maitraie D, Hung CF, Tu HY, et al. Synthesis, anti-inflammatory and antioxidant activities of 18B-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors[J]. Bioorg Med Chem,2009,17 (7):2785.
[26]	Wang Y, Zhu JX, Kong LD, et al. Administration of procyanidins from grape seecls reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice[J]. Basic Clin Pharmacology & Toxicology, 2004, 94 (5):232.
[27]	Zhu JX, WangY, Kong LD, et al. Effects of Biota orientalis extract and its flavonoid constituents quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver[J].J Ethnopharmacol, 2004, 93 (1): 133.
[28]	Yoshizumi K, Nishioka N, Tsuji T. Xanthine oxidase inhibitory activity and hyypouricemia effect of propolis in rats[J]. Journal of the Pharmaceutical Society of Japan, 2005, 125 (3):315.
[29]	Lin HC, Tsai SH, Chen CS, et al. Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities[J]. Biochem Pharmacol,2008, 75: 1416.
[30]	Odontuya GJ, Hoult RS, Houghton PJ. Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides[J]. Phytother Res, 2005, 19, 782.
[31]	薛莎,朱琼洁,马威. 伸秦组方对高尿酸血症小鼠的影响[J].中国药物经济学,2010, 2:87.
[32]	杨和金,苏梅,赵春梅,等. 痛风液抗痛风性关节炎的实验研究[J].中草药, 2010, 9 (41):1504.
[33]	陈海生,乔丽名,刘建国,等. 芹菜籽黄酮类和香豆素类化合物在制备防治痛风药物的用途,中国发明专利 ZL 200710062800.6.

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Advance in drug therapy of gout

doi: 10.3969/j.issn.1006-0111.2013.01.004

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

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