Advances in polymeric micelles for drug delivery and tumor targeting

WU Yun-tao; ZHANG Yi-yi

doi:10.3969/j.issn.1006-0111.2013.02.002

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2013 > 31(2): 86-89,115

WU Yun-tao, ZHANG Yi-yi. Advances in polymeric micelles for drug delivery and tumor targeting[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 86-89,115. doi: 10.3969/j.issn.1006-0111.2013.02.002

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WU Yun-tao, ZHANG Yi-yi. Advances in polymeric micelles for drug delivery and tumor targeting[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 86-89,115. doi: 10.3969/j.issn.1006-0111.2013.02.002

Advances in polymeric micelles for drug delivery and tumor targeting

doi: 10.3969/j.issn.1006-0111.2013.02.002

Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, China

Received Date: 2012-05-05
Rev Recd Date: 2012-10-09

Abstract

Some unique inherent properties of polymeric micelles, including small particle size, high stability, long residence time, and good biocompatibility allowed polymeric micelles to be used as drug carriers. In recent years, increasing reports about the polymer micelles had been designed for tumor targeted drug delivery systems, including passive targeted drug delivery using tumor pathological nature and active targeting drug delivery using surface modification of polymer micelles. The research progress of polymeric micelles used as tumor targeted drug carriers were reviewed in this paper.
- polymeric micelle,
- block copolymer,
- tumor targeting,
- drug carrier

References

[1]	Wang L, Zeng R, Li C, et al. Self-assembled polypeptide-block-poly (vinylpyrrolidone) as prospective drug-delivery systems[J]. Colloids and Surfaces B:Biointerfaces, 2009, 74:284.
[2]	Yokoyama M, Okano T, Sakurai Y, et al. Introduction of cisplatin into polymeric micelles[J]. J Control Release, 1996, 39:351.
[3]	Shen Y, Jiasheng T. Synthesis and characterization of low molecular weight hyaluronic acid-based cationic micelles for efficient siRNA delivery[J]. Carbohydrate Polym, 2009, 77:95.
[4]	Rijcken CJ, Snel CJ, Schiffelers RM, et al. Hydrolysable core-crosslinked thermosensitive polymeric micelles:synthesis, characterisation and in vivo studies[J]. Biomaterials, 2007, 28:5581.
[5]	Otsuka H, Nagasaki Y, Kataoka K. PEGylated nanoparticles for biological and pharmaceutical applications[J]. Adv Drug Deliv Rev, 2003, 55:403.
[6]	Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings[J]. Adv Drug Deliv Rev, 2001, 46:3.
[7]	Zhang Z, Grijpma DW, Feijen J. Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles[J]. J Control Release, 2006, 112:57.
[8]	Li Y, Kwon GS. Methotrexate esters of poly(ethyleneoxide)-blockpoly(2-hydroxyethyl-L-aspartamide). I Effects of the level of methotrexate conjugation on the stability of micelles and on drug release[J]. Pharm Res, 2000, 17:607.
[9]	Kozlov MY, Melik-Nubarov NS, Batrakova EV, et al. Relationship between Pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes[J]. Macromolecules, 2000, 33:3305.
[10]	Lavasanifar A, Samuel J, Kwon GS. The effect of alkyl core structure on micellar properties of poly(ethylene oxide)-block-poly(Laspartamide) derivatives[J]. Colloids Surfaces B Biointerfaces, 2001, 22:115.
[11]	Lee ES, Na K, Bae YH. Polymeric micelles for tumor pH and folate mediated targeting[J]. J Control Release, 2003, 91:103.
[12]	Lee ES, Na K, Bae YH, et al. Poly(l-histidine)-PEG block copolymer micelles and pH-induced destabilization[J]. J Control Release, 2003, 90:363.
[13]	Rejinold NS, Muthunarayanan M, Divyarani VV, et al. Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles for cancer drug delivery[J]. J Colloid Interface Sci, 2011, 360:39.
[14]	Rejinold NS, Sreerekha PR, Chennazhi KP, et al. Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery[J]. Int J Biol Macromol, 2011, 49:161.
[15]	Kim JH, Emoto K, Iijima M, et al. Core-stabilized polymeric micelle as potential drug carrier:increased solubilization of taxol[J]. Polym Adv Technol, 1999, 10:647.
[16]	Butsele KV, Sibreta P, Fustin CA, et al. Synthesis and pH-dependent micellization of diblock copolymer mixtures[J]. J Colloid Interf Sci, 2009, 329:235.
[17]	Patil YB, Toti US, Khdair A, et al. Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery[J]. Biomaterials, 2009, 30:859.
[18]	Taillefer J, Jones MC, Brasseur N, et al. Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs[J]. J Pharm Sci, 2000, 89:52.
[19]	Der ZL, Jui HH, Xian CF, et al. Synthesis, characterization and drug delivery behaviors of new PCP polymeric micelles[J]. Carbohydrate Polym, 2007, 68:544.
[20]	Adams ML, Lavasanifar A, Kwon GS. Amphiphilic block copolymers for drug delivery[J]. J Pharm Sci, 2003, 92:1343.
[21]	Yunhai L, Xiaohong C, Mingbiao L, et al. Selfassembled micellar nanoparticles of a novel star copolymer for thermo and pH dual-responsive drug release[J]. J Colloid Interf Sci, 2009, 329:244.
[22]	Wilhelm M, Zhao CL, Wang YC, et al. Poly(styrene-ethylene oxide) block copolymer micelle formation in water:a fluorescence probe study[J]. Macromolecules, 1991, 24:1033.
[23]	Chen Y, Sone M, Fuchise K, et al. Structural effect of a series of block copolymers consisting of poly(Nisopropylacrylamide and poly(N-hydroxyethylacrylamide) on thermoresponsiv behavior[J]. React Funct Polym, 2009, 69:463.
[24]	Cho YW, Lee J, Lee SC, et al. Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles[J]. J Control Release, 2004, 97:249.
[25]	Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature, the key role of tumor selective macromolecular drug targeting[J]. Adv Enzyme Regul, 2001, 41:189.
[26]	Acharya S, Sahoo SK. PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect[J]. Adv Drug Deliv Rev, 2011, 63:170.
[27]	Torchillin VP, Iakaubov LZ, Estrov Z. Therapeutic potential of antinuclear autoantibodies in cancer[J]. Cancer Ther, 2003, 1:179.
[28]	Knock E, Deng L, Krupenko N, et al. Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair[J]. J Nutr Biochem, 2011, 22:1022.
[29]	Hageluken A, Grunbaum L, Numberg B, et al. Lipophilic beta-adrenoceptor antagonist and local anaesthetics are effective direct activators of G-proteins[J]. Biochem Pharmacol, 1994, 47:1789.
[30]	Dharap SS, Qiu B, Williams GC, et al. Molecular targeting of drug delivery systems to ovarian cancers by BH3 and LHRH peptides[J]. J Control Release, 2003, 91:61.
[31]	Lee AL, Yong W, Cheng HY, et al. The co-delivery of paclitaxel and Herceptin using cationic micellar nanoparticles[J]. Biomaterials, 2009, 30:919.
[32]	Rijcken CJ, Snel CJ, Schiffelers RM, et al. Hydrolysable core-crosslinked thermosensitive polymeric micelles:synthesis, characterisation and in vivo studies[J]. Biomaterials, 2007, 28:5581.
[33]	Mannaris C, Averkiou MA. Investigation of microbubble response to long pulses used in ultrasound-enhanced drug delivery[J]. Ultrasound Med Biol, 2012, 38:681.
[34]	Wei A, Zhou D, Ruan J, et al. Anti-tumor and anti-angiogenic effects of Macrothelypteris viridifrons and its constituents by HPLC-DAD/MS analysis[J]. J Ethnopharmacol, 2012, 139:373.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Advances in polymeric micelles for drug delivery and tumor targeting

Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, China

Received Date: 2012-05-05

Rev Recd Date: 2012-10-09

Key words:

Abstract: Some unique inherent properties of polymeric micelles, including small particle size, high stability, long residence time, and good biocompatibility allowed polymeric micelles to be used as drug carriers. In recent years, increasing reports about the polymer micelles had been designed for tumor targeted drug delivery systems, including passive targeted drug delivery using tumor pathological nature and active targeting drug delivery using surface modification of polymer micelles. The research progress of polymeric micelles used as tumor targeted drug carriers were reviewed in this paper.

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Reference (34)

[1]	Wang L, Zeng R, Li C, et al. Self-assembled polypeptide-block-poly (vinylpyrrolidone) as prospective drug-delivery systems[J]. Colloids and Surfaces B:Biointerfaces, 2009, 74:284.
[2]	Yokoyama M, Okano T, Sakurai Y, et al. Introduction of cisplatin into polymeric micelles[J]. J Control Release, 1996, 39:351.
[3]	Shen Y, Jiasheng T. Synthesis and characterization of low molecular weight hyaluronic acid-based cationic micelles for efficient siRNA delivery[J]. Carbohydrate Polym, 2009, 77:95.
[4]	Rijcken CJ, Snel CJ, Schiffelers RM, et al. Hydrolysable core-crosslinked thermosensitive polymeric micelles:synthesis, characterisation and in vivo studies[J]. Biomaterials, 2007, 28:5581.
[5]	Otsuka H, Nagasaki Y, Kataoka K. PEGylated nanoparticles for biological and pharmaceutical applications[J]. Adv Drug Deliv Rev, 2003, 55:403.
[6]	Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings[J]. Adv Drug Deliv Rev, 2001, 46:3.
[7]	Zhang Z, Grijpma DW, Feijen J. Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles[J]. J Control Release, 2006, 112:57.
[8]	Li Y, Kwon GS. Methotrexate esters of poly(ethyleneoxide)-blockpoly(2-hydroxyethyl-L-aspartamide). I Effects of the level of methotrexate conjugation on the stability of micelles and on drug release[J]. Pharm Res, 2000, 17:607.
[9]	Kozlov MY, Melik-Nubarov NS, Batrakova EV, et al. Relationship between Pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes[J]. Macromolecules, 2000, 33:3305.
[10]	Lavasanifar A, Samuel J, Kwon GS. The effect of alkyl core structure on micellar properties of poly(ethylene oxide)-block-poly(Laspartamide) derivatives[J]. Colloids Surfaces B Biointerfaces, 2001, 22:115.
[11]	Lee ES, Na K, Bae YH. Polymeric micelles for tumor pH and folate mediated targeting[J]. J Control Release, 2003, 91:103.
[12]	Lee ES, Na K, Bae YH, et al. Poly(l-histidine)-PEG block copolymer micelles and pH-induced destabilization[J]. J Control Release, 2003, 90:363.
[13]	Rejinold NS, Muthunarayanan M, Divyarani VV, et al. Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles for cancer drug delivery[J]. J Colloid Interface Sci, 2011, 360:39.
[14]	Rejinold NS, Sreerekha PR, Chennazhi KP, et al. Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery[J]. Int J Biol Macromol, 2011, 49:161.
[15]	Kim JH, Emoto K, Iijima M, et al. Core-stabilized polymeric micelle as potential drug carrier:increased solubilization of taxol[J]. Polym Adv Technol, 1999, 10:647.
[16]	Butsele KV, Sibreta P, Fustin CA, et al. Synthesis and pH-dependent micellization of diblock copolymer mixtures[J]. J Colloid Interf Sci, 2009, 329:235.
[17]	Patil YB, Toti US, Khdair A, et al. Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery[J]. Biomaterials, 2009, 30:859.
[18]	Taillefer J, Jones MC, Brasseur N, et al. Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs[J]. J Pharm Sci, 2000, 89:52.
[19]	Der ZL, Jui HH, Xian CF, et al. Synthesis, characterization and drug delivery behaviors of new PCP polymeric micelles[J]. Carbohydrate Polym, 2007, 68:544.
[20]	Adams ML, Lavasanifar A, Kwon GS. Amphiphilic block copolymers for drug delivery[J]. J Pharm Sci, 2003, 92:1343.
[21]	Yunhai L, Xiaohong C, Mingbiao L, et al. Selfassembled micellar nanoparticles of a novel star copolymer for thermo and pH dual-responsive drug release[J]. J Colloid Interf Sci, 2009, 329:244.
[22]	Wilhelm M, Zhao CL, Wang YC, et al. Poly(styrene-ethylene oxide) block copolymer micelle formation in water:a fluorescence probe study[J]. Macromolecules, 1991, 24:1033.
[23]	Chen Y, Sone M, Fuchise K, et al. Structural effect of a series of block copolymers consisting of poly(Nisopropylacrylamide and poly(N-hydroxyethylacrylamide) on thermoresponsiv behavior[J]. React Funct Polym, 2009, 69:463.
[24]	Cho YW, Lee J, Lee SC, et al. Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles[J]. J Control Release, 2004, 97:249.
[25]	Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature, the key role of tumor selective macromolecular drug targeting[J]. Adv Enzyme Regul, 2001, 41:189.
[26]	Acharya S, Sahoo SK. PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect[J]. Adv Drug Deliv Rev, 2011, 63:170.
[27]	Torchillin VP, Iakaubov LZ, Estrov Z. Therapeutic potential of antinuclear autoantibodies in cancer[J]. Cancer Ther, 2003, 1:179.
[28]	Knock E, Deng L, Krupenko N, et al. Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair[J]. J Nutr Biochem, 2011, 22:1022.
[29]	Hageluken A, Grunbaum L, Numberg B, et al. Lipophilic beta-adrenoceptor antagonist and local anaesthetics are effective direct activators of G-proteins[J]. Biochem Pharmacol, 1994, 47:1789.
[30]	Dharap SS, Qiu B, Williams GC, et al. Molecular targeting of drug delivery systems to ovarian cancers by BH3 and LHRH peptides[J]. J Control Release, 2003, 91:61.
[31]	Lee AL, Yong W, Cheng HY, et al. The co-delivery of paclitaxel and Herceptin using cationic micellar nanoparticles[J]. Biomaterials, 2009, 30:919.
[32]	Rijcken CJ, Snel CJ, Schiffelers RM, et al. Hydrolysable core-crosslinked thermosensitive polymeric micelles:synthesis, characterisation and in vivo studies[J]. Biomaterials, 2007, 28:5581.
[33]	Mannaris C, Averkiou MA. Investigation of microbubble response to long pulses used in ultrasound-enhanced drug delivery[J]. Ultrasound Med Biol, 2012, 38:681.
[34]	Wei A, Zhou D, Ruan J, et al. Anti-tumor and anti-angiogenic effects of Macrothelypteris viridifrons and its constituents by HPLC-DAD/MS analysis[J]. J Ethnopharmacol, 2012, 139:373.

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Advances in polymeric micelles for drug delivery and tumor targeting

doi: 10.3969/j.issn.1006-0111.2013.02.002

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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