Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation

HUANG Jin; ZENG Ying; TANG Fan; YUAN Fang

doi:10.3969/j.issn.1006-0111.2016.05.002

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Volume 34 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2016 > 34(5): 389-392,398

HUANG Jin, ZENG Ying, TANG Fan, YUAN Fang. Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 389-392,398. doi: 10.3969/j.issn.1006-0111.2016.05.002

Citation:

HUANG Jin, ZENG Ying, TANG Fan, YUAN Fang. Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 389-392,398. doi: 10.3969/j.issn.1006-0111.2016.05.002

Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation

doi: 10.3969/j.issn.1006-0111.2016.05.002

1.
Department of Pharmacy, Pudong New Area People's Hospital, Shanghai 201299, China
2.
School of Pharmacy, Bengbu Medical College, Bengbu 233030, China

Received Date: 2016-03-25
Rev Recd Date: 2016-06-13

Abstract

Clopidogrel is commonly used as an anti-platelet aggregation drug in the clinical treatment, which is often used in combination with traditional Chinese medicine. Strengthening the study on the interaction mechanism of Chinese herbal medicine and its active components with clopidogrel, to improve the effect of anti-platelet aggregation and the therapeutic effect of clopidogrel resistance. The research progress on the interaction of Chinese herbal medicine and its active components with clopidogrel were summarized in domestic and foreign literatures. Cytochrome P450, liver carboxylesterase, P glycoprotein is a major part of the interaction of traditional Chinese medicine and its active ingredient of clopidogrel. Some active components in Chinese medicine have synergistic effect of clopidogrel on platelet aggregation.
- traditional Chinese medicine and its active components,
- clopidogrel,
- platelet aggregation,
- interaction,
- acute coronary syndrome,
- ischemic stroke

References

[1]	艾美仕. 2014医院卖得最好的20个中成药[EB/OL]. 2014-12-12[2016-3-25].http://news.bioon.com/article/6663637.html.
[2]	Tachjian A,Maria V,Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases [J]. J Am Coll Cardiol,2010,55(6): 515-525.
[3]	中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国缺血性脑卒中和短暂性脑缺血发作二级预防指南2014[J]. 中华神经科杂志,2015,48(4):258-273.
[4]	Posadzki P,Watson L,Ernst E. Herb-drug interactions: an overview of systematic reviews[J]. Br J Clin Pharmacol,2013,75(3): 603-618.
[5]	张萍,白如冰,马洪山. 通心络胶囊对急性冠脉综合征患者氯吡格雷抵抗的影响[J].中西医结合心脑血管病杂志,2010,8(9):1037-1038.
[6]	张俊平,白如冰. 不同负荷剂量及维持量氯吡格雷对急性冠脉综合征患者氯吡格雷抵抗的影响[J]. 中西医结合心脑血管病杂志,2010,8(6):665-666.
[7]	卜明华,郑咏秋,张颖,等. 心血管药物速效救心丸和通心络胶囊对大鼠细胞色素P450酶的影响[J]. 中国临床药理学与治疗学,2011,16(6):601-605.
[8]	Han YL. Tongxinluo Improve High on Clopidogrel Platelet Reactivity Patients With Coronary Heart Disease (Talent)[EB/OL].2012-11-01[2016-03-22]. https://clinicaltrials.gov/ct2/show/study/NCT01721590?term=TONGXIN LUO&rank=1
[9]	马世堂.基于计算药理学的复方丹参滴丸对氯吡格雷代谢酶的影响[J]. 中药材,2015,38(5):1009-1012.
[10]	Lee JH, Shin YJ, Kim HJ, et al. Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel,reflecting its negligible potential in P-glycoprotein- and cytochromeP4503A-mediated herb-drug interactions[J]. Int J Pharm,2011,410(1-2): 68-74.
[11]	Liu L, Li J, Zhang Y,et al.Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor: Evidence from clinic to laboratory [J]. Thromb Res,2014,134(4): 866-876.
[12]	刘丽雅,韩永龙,余奇,等. 10种心血管类中药注射剂对人细胞色素P450 7种亚型的体外抑制作用[J]. 中国药房,2014,25(11):990-993.
[13]	李丽,李艳红,王宁生. 当归、红花与硫酸氢氯吡格雷抗血小板聚集的相互作用[J]. 中药新药与临床药理,2009,20(1):14-17.
[14]	夏玉叶,闵旸,盛雨辰,等. 羟基红花黄色素A对大鼠血栓形成和血小板聚集功能的影响[J].中国药理学通报,2005,21(11):1400.
[15]	刘志峰,李萍,李挂生,等.红花提取物抗血小板聚集及抗血栓作用的观察[J].中药药理与临床,2000,16(6):20.
[16]	张欣,李红,於四军,等. 丹红注射液联合氯吡格雷治疗不稳定型心绞痛疗效及对血液流变学的影响[J]. 临床和实验医学杂志,2014,13(24):2058-2061.
[17]	赵菁,耿文静,翟博智. 血栓通注射液治疗急性脑梗死氯吡格雷抵抗的临床观察[J]. 中草药,2015,46(14):2122-2126.
[18]	韩永龙,李丹,孟祥乐,等. 血塞通注射液对鼠肝CYP3A体外抑制作用研究[J]. 中国药师,2010,13(5):642-644.
[19]	Liu AC, Zhao LX, Yu SW, et al. Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats[J]. Chin J Nat Med, 2015,13(4): 257-263.
[20]	王婕,林成仁,王敏.中药对血小板功能影响的研究进展[J].北京中医药,2008,27(11):893-896.
[21]	Przyklenk K, Frelinger AL 3rd, Linden MD, et al.Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis[J].J Thromb Haemost,2010,8(2):331-340.[22] 白颖,李林.中药抗血小板作用及其机制研究进展[J].中华中医药杂志,2011,26(4):770-773.
[22]	李丹,韩永龙,余涛,等. 常用中药单体及其制剂对CYP3A活性的体外抑制作用研究[J]. 中国药师,2014,17(8):1259-1263.
[23]	欧阳冬生,帅放文,周宏灏.药用辅料对细胞色素P450氧化酶的作用研究进展[J].中国临床药理学与治疗学,2013,18(1):99-102.
[24]	刘东,张程亮. 羧酸酯酶与酯类药物代谢[J]. 医药导报,2010,29(3):332-335
[25]	Kim BH, Kim JR, Lim KS, et al. Comparative pharmacokinetics/pharmacodynamics of clopidogrelbesylate and clopidogrel bisulfate in healthy Korean subjects[J].Clin Drug Investig,2012,32(12):817-826.
[26]	刘帅兵,丁肖梁,黄晨蓉,等. 氯吡格雷的体外相互作用研究[J]. 中国血液流变学杂志.2014,24(1):12-15.
[27]	许永福,饶志. 银杏叶片对氯吡格雷大鼠体内药物动力学的影响[J]. 甘肃医药,2013,32(1):14-17.
[28]	Apitz-Castro R, Cabrera S, Cruz MR, et al. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reactionand platelet ultrastructure[J]. Thromb Res,1983,32(2):155-169.
[29]	German K, Kumar U, Blackford HN. Garlic and the risk of TURP bleeding[J]. Br J Urol,1995,76(4):518.
[30]	Akhtar MS, Ramzan A, Ali A, et al. Effect of amla fruit(Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjectsand type 2 diabetic patients[J]. Int J Food Sci Nutr. 2011,62(6):609-616.
[31]	Sanhita P, Chandra KJ, Chandra SG. Important findings of plants having antioxidant property.A review [J].Int Res J Pharm,2012,3(5): 72-75.
[32]	Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type Ⅱ diabetesmellitus[J]. Phytomedicine,2014,21(5): 579-585.
[33]	马世堂,戴国梁,孙冰婷,等.氯吡格雷对复方丹参滴丸药动学的影响[J].中药材,2014,37(12):2240-2243.
[34]	Li Y, Liu C, Zhang Y, et al. Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats[J]. J Ethnopharmacol,2011,137(1): 562-567.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation

1. Department of Pharmacy, Pudong New Area People's Hospital, Shanghai 201299, China

2. School of Pharmacy, Bengbu Medical College, Bengbu 233030, China

Received Date: 2016-03-25

Rev Recd Date: 2016-06-13

Key words:

traditional Chinese medicine and its active components /
clopidogrel /
platelet aggregation /
interaction /
acute coronary syndrome /
ischemic stroke

Abstract: Clopidogrel is commonly used as an anti-platelet aggregation drug in the clinical treatment, which is often used in combination with traditional Chinese medicine. Strengthening the study on the interaction mechanism of Chinese herbal medicine and its active components with clopidogrel, to improve the effect of anti-platelet aggregation and the therapeutic effect of clopidogrel resistance. The research progress on the interaction of Chinese herbal medicine and its active components with clopidogrel were summarized in domestic and foreign literatures. Cytochrome P450, liver carboxylesterase, P glycoprotein is a major part of the interaction of traditional Chinese medicine and its active ingredient of clopidogrel. Some active components in Chinese medicine have synergistic effect of clopidogrel on platelet aggregation.

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Reference (34)

[1]	艾美仕. 2014医院卖得最好的20个中成药[EB/OL]. 2014-12-12[2016-3-25].http://news.bioon.com/article/6663637.html.
[2]	Tachjian A,Maria V,Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases [J]. J Am Coll Cardiol,2010,55(6): 515-525.
[3]	中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国缺血性脑卒中和短暂性脑缺血发作二级预防指南2014[J]. 中华神经科杂志,2015,48(4):258-273.
[4]	Posadzki P,Watson L,Ernst E. Herb-drug interactions: an overview of systematic reviews[J]. Br J Clin Pharmacol,2013,75(3): 603-618.
[5]	张萍,白如冰,马洪山. 通心络胶囊对急性冠脉综合征患者氯吡格雷抵抗的影响[J].中西医结合心脑血管病杂志,2010,8(9):1037-1038.
[6]	张俊平,白如冰. 不同负荷剂量及维持量氯吡格雷对急性冠脉综合征患者氯吡格雷抵抗的影响[J]. 中西医结合心脑血管病杂志,2010,8(6):665-666.
[7]	卜明华,郑咏秋,张颖,等. 心血管药物速效救心丸和通心络胶囊对大鼠细胞色素P450酶的影响[J]. 中国临床药理学与治疗学,2011,16(6):601-605.
[8]	Han YL. Tongxinluo Improve High on Clopidogrel Platelet Reactivity Patients With Coronary Heart Disease (Talent)[EB/OL].2012-11-01[2016-03-22]. https://clinicaltrials.gov/ct2/show/study/NCT01721590?term=TONGXIN LUO&rank=1
[9]	马世堂.基于计算药理学的复方丹参滴丸对氯吡格雷代谢酶的影响[J]. 中药材,2015,38(5):1009-1012.
[10]	Lee JH, Shin YJ, Kim HJ, et al. Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel,reflecting its negligible potential in P-glycoprotein- and cytochromeP4503A-mediated herb-drug interactions[J]. Int J Pharm,2011,410(1-2): 68-74.
[11]	Liu L, Li J, Zhang Y,et al.Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor: Evidence from clinic to laboratory [J]. Thromb Res,2014,134(4): 866-876.
[12]	刘丽雅,韩永龙,余奇,等. 10种心血管类中药注射剂对人细胞色素P450 7种亚型的体外抑制作用[J]. 中国药房,2014,25(11):990-993.
[13]	李丽,李艳红,王宁生. 当归、红花与硫酸氢氯吡格雷抗血小板聚集的相互作用[J]. 中药新药与临床药理,2009,20(1):14-17.
[14]	夏玉叶,闵旸,盛雨辰,等. 羟基红花黄色素A对大鼠血栓形成和血小板聚集功能的影响[J].中国药理学通报,2005,21(11):1400.
[15]	刘志峰,李萍,李挂生,等.红花提取物抗血小板聚集及抗血栓作用的观察[J].中药药理与临床,2000,16(6):20.
[16]	张欣,李红,於四军,等. 丹红注射液联合氯吡格雷治疗不稳定型心绞痛疗效及对血液流变学的影响[J]. 临床和实验医学杂志,2014,13(24):2058-2061.
[17]	赵菁,耿文静,翟博智. 血栓通注射液治疗急性脑梗死氯吡格雷抵抗的临床观察[J]. 中草药,2015,46(14):2122-2126.
[18]	韩永龙,李丹,孟祥乐,等. 血塞通注射液对鼠肝CYP3A体外抑制作用研究[J]. 中国药师,2010,13(5):642-644.
[19]	Liu AC, Zhao LX, Yu SW, et al. Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats[J]. Chin J Nat Med, 2015,13(4): 257-263.
[20]	王婕,林成仁,王敏.中药对血小板功能影响的研究进展[J].北京中医药,2008,27(11):893-896.
[21]	Przyklenk K, Frelinger AL 3rd, Linden MD, et al.Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis[J].J Thromb Haemost,2010,8(2):331-340.[22] 白颖,李林.中药抗血小板作用及其机制研究进展[J].中华中医药杂志,2011,26(4):770-773.
[22]	李丹,韩永龙,余涛,等. 常用中药单体及其制剂对CYP3A活性的体外抑制作用研究[J]. 中国药师,2014,17(8):1259-1263.
[23]	欧阳冬生,帅放文,周宏灏.药用辅料对细胞色素P450氧化酶的作用研究进展[J].中国临床药理学与治疗学,2013,18(1):99-102.
[24]	刘东,张程亮. 羧酸酯酶与酯类药物代谢[J]. 医药导报,2010,29(3):332-335
[25]	Kim BH, Kim JR, Lim KS, et al. Comparative pharmacokinetics/pharmacodynamics of clopidogrelbesylate and clopidogrel bisulfate in healthy Korean subjects[J].Clin Drug Investig,2012,32(12):817-826.
[26]	刘帅兵,丁肖梁,黄晨蓉,等. 氯吡格雷的体外相互作用研究[J]. 中国血液流变学杂志.2014,24(1):12-15.
[27]	许永福,饶志. 银杏叶片对氯吡格雷大鼠体内药物动力学的影响[J]. 甘肃医药,2013,32(1):14-17.
[28]	Apitz-Castro R, Cabrera S, Cruz MR, et al. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reactionand platelet ultrastructure[J]. Thromb Res,1983,32(2):155-169.
[29]	German K, Kumar U, Blackford HN. Garlic and the risk of TURP bleeding[J]. Br J Urol,1995,76(4):518.
[30]	Akhtar MS, Ramzan A, Ali A, et al. Effect of amla fruit(Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjectsand type 2 diabetic patients[J]. Int J Food Sci Nutr. 2011,62(6):609-616.
[31]	Sanhita P, Chandra KJ, Chandra SG. Important findings of plants having antioxidant property.A review [J].Int Res J Pharm,2012,3(5): 72-75.
[32]	Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type Ⅱ diabetesmellitus[J]. Phytomedicine,2014,21(5): 579-585.
[33]	马世堂,戴国梁,孙冰婷,等.氯吡格雷对复方丹参滴丸药动学的影响[J].中药材,2014,37(12):2240-2243.
[34]	Li Y, Liu C, Zhang Y, et al. Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats[J]. J Ethnopharmacol,2011,137(1): 562-567.

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Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation

doi: 10.3969/j.issn.1006-0111.2016.05.002

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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