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2016 Vol. 34, No. 5

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Research progress of in vivo biomarkers for CYP3A enzyme
ZHU Sang, ZHANG Feng, GAO Shouhong, WANG Zhipeng, CHEN Wangsheng, TAO Xia
2016, 34(5): 385-388,402. doi: 10.3969/j.issn.1006-0111.2016.05.001
Abstract:
Human cytochrome P450 (CYP) 3A, which is widely involved in the various drug metabolism, is most abundant in liver and intestine. The activity of CYP3A enzyme may be induced or inhibited in the process of drug metabolisms, and affect the metabolism o...
Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation
HUANG Jin, ZENG Ying, TANG Fan, YUAN Fang
2016, 34(5): 389-392,398. doi: 10.3969/j.issn.1006-0111.2016.05.002
Abstract(4917) PDF (819KB)(1081)
Abstract:
Clopidogrel is commonly used as an anti-platelet aggregation drug in the clinical treatment, which is often used in combination with traditional Chinese medicine. Strengthening the study on the interaction mechanism of Chinese herbal medicine and its...
Progress on the anti-tumor activity of seaweed polysaccharides
ZHANG Yue, WANG Jing, LI Tiejun
2016, 34(5): 393-395,473. doi: 10.3969/j.issn.1006-0111.2016.05.003
Abstract(4042) PDF (794KB)(1493)
Abstract:
Seaweed polysaccharides are not only a direct inhibitory effect on tumor cells, but also an indirect therapeutic effected by enhancing immune function or inhibiting tumor cell metastasis. Seaweed polysaccharides could inhibit the growth of tumor cell...
Humble opinions on problems and solutions for protection of Chinese medicinal material resources
SI Yaqing, JIANG Yiping, XIN Hailiang
2016, 34(5): 396-398. doi: 10.3969/j.issn.1006-0111.2016.05.004
Abstract(4090) PDF (406KB)(610)
Abstract:
Chinese medicinal materials, as main treatment measures, are commonly used in clinic practice of Chinese traditional medicine with long history, and a significant proportion of Chinese medicinal material resources are from wild resource. Unreasonable...
Effects of Ludisia discolor aqueous extract on exercise capacity, serum lactic acid, urea nitrogen and hepatic glycogen in mice
SHI Hekun, CHEN Kaijie, LIN Xiaofeng, CHEN Jinsan
2016, 34(5): 399-402. doi: 10.3969/j.issn.1006-0111.2016.05.005
Abstract(3657) PDF (420KB)(1091)
Abstract:
Objective To investigate the effect against exercise-indused fatigue in mice by aqueous extract of Ludisia discolor and its mechanism. Methods Male mice were randomly divided into five groups including low, middle, high dose groups [aqueous extrac...
Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury
GAO Yue, CHEN Anni, ZHAO Yahong, XUE Dan, AN Yongtong, CHAI Yifeng, ZHANG Hai
2016, 34(5): 403-407,415. doi: 10.3969/j.issn.1006-0111.2016.05.006
Abstract:
Objective Experimental study on effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury in order to provide a theoretical basis for its clinical application. M...
Nutritional risk screening and nutritional support survey of patients with severe stroke
LIU Chun, YANG Xiaochen, CHEN Bowen, SHANG Erning
2016, 34(5): 408-411. doi: 10.3969/j.issn.1006-0111.2016.05.007
Abstract(3481) PDF (274KB)(451)
Abstract:
Objective To discuss the signficance using nutrtional risk screening (NRS) to evaluate nutritional status in patients with severe stroke. In the meantime compare the clinical application value between enteral and parenteral nutritional support thera...
Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine
YU Hui, YANG Hong, WAN Fanghui, HAN Xuemin, WANG Daoling, ZHAO Xiaohong
2016, 34(5): 412-415. doi: 10.3969/j.issn.1006-0111.2016.05.008
Abstract(3737) PDF (682KB)(722)
Abstract:
Objective To evaluate effects of dexmedetomidine on onset, duration of supraclavicular brachial plexus block induced by levobupivacaine and postoperative analgesia with ultrasound guide. Methods Eighty patients undergoing elective surgeries of dis...
Optimization of the separation and purification process for iridoid glycosides from Lamioplomisrotata
TAO Rui, FU Meng, CAO Xinyuan, LI Maoxing
2016, 34(5): 416-420,449. doi: 10.3969/j.issn.1006-0111.2016.05.009
Abstract:
Objective To obtain iridoid glycosides with relatively high purity by the optimization of the preparation process of iridoid glycosides from Lamioplomisrotata. Methods Used methanol-water mobile phase with gradient run to set up an HPLC method and...
The evaluation and analysis on the results of voriconazole plasma concentration monitoring
YAN Miao, WANG Ningning, LI Ziwei, JIANG Mengfei, WANG Feng, ZHANG Bikui, XU Ping, XIAO Yiwen
2016, 34(5): 421-423,446. doi: 10.3969/j.issn.1006-0111.2016.05.010
Abstract:
Objective To clarify the necessity of therapeutic drug monitoring (TDM) of voriconazole, and give relevant clinical tips, by comparing the plasma concentration of different clinical specialties before and after adjustment of dose. Methods This is ...
TLC identification and determination of total flavonoids in Compound caulis Polygoni multiflori mixture
ZENG Qiping, CAO Yixiang, HUANG Lishan, ZHANG Rong
2016, 34(5): 424-427. doi: 10.3969/j.issn.1006-0111.2016.05.011
Abstract:
Objective To establish the quality control standards for Compound caulis Polygoni multiflori mixture. Methods Caulis polygoni multiflori, cortex alibiziae and schisand chinensis were identified by TLC, total flavonoids were determined by UV. Resu...
Determination of levofloxacin concentration in plasma of Chinese healthy volunteers by HPLC with fluorescence detection and bioequivalence study of levofloxacin hydrochloride tablets
YANG Xiaoying, ZHANG Wenping, WANG Xinyu, DANG Hongwan
2016, 34(5): 428-430,440. doi: 10.3969/j.issn.1006-0111.2016.05.012
Abstract:
Objective To develop a HPLC-fluorescence method to determine levofloxacin concentration in plasma for studying bioequivalence of levofloxacin hydrochloride tablet in Chinese healthy volunteers. Methods A single-dose of 0.2 g test or reference prep...
Three new triterpene glycosides from Stichopus variegatus
WANG Qiang, WANG Xiaohua
2016, 34(5): 431-436,454. doi: 10.3969/j.issn.1006-0111.2016.05.013
Abstract:
Objective To study the chemical constituents from the Stichopus variegatus. Method The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 gel filtration and recrystallization. The structures of these compounds...
A ESI-based analysis of hot literatures on pharmacology & toxicology
WANG Xia, LV Chuanlu, SUN Xiaoxi
2016, 34(5): 437-440. doi: 10.3969/j.issn.1006-0111.2016.05.014
Abstract(3563) PDF (257KB)(557)
Abstract:
Objective To analyze the outputof hotliteratures on pharmacology & toxicology in the world. Methods Essential Science Indicators Database were retrievedandthe national distribution, published journals and hot research topics of hot literatures wer...
HPLC method to assay the content of psoralen and angelicin in Zhuanggu granules
PU Jin, XU Liangyan, CHEN Ruohua
2016, 34(5): 441-442. doi: 10.3969/j.issn.1006-0111.2016.05.015
Abstract(3390) PDF (632KB)(463)
Abstract:
Objective To develop a HPLC method for psoralenand angelicin content assay in Zhuanggu granules. Methods Agilent Zorbax C18 column(4.6 mm×250 mm, 5 μm) was used with methanol and water(45:55) as mobile phase. The detection wavelength was set at 24...
Determination of matrine in Lefu oral liquid by HPLC
WU Xianglei, YUE Ming, HUANG Hao, LU Wenquan, PIAO Shujuan, ZHANG Feng
2016, 34(5): 443-446. doi: 10.3969/j.issn.1006-0111.2016.05.016
Abstract(3048) PDF (507KB)(517)
Abstract:
Objective To establish a high performance liquid chromatography method for the determination of matrine in Lefu oral liquid. Methods The HPLC method was performed on a Diamonsil Platisil NH2 column (4.6 mm×250 mm, 5 μm) with the mobile phase of ac...
Determination of baicalin in Kangdeling capsule by HPLC
JIANG Shuwen, LIU Jieping, XIAO Qiusheng, XIAO Jinbao, SHI Chunshan, SUN Dan, JIANG Zongwen
2016, 34(5): 447-449. doi: 10.3969/j.issn.1006-0111.2016.05.017
Abstract(3575) PDF (562KB)(415)
Abstract:
Objective To establish an HPLC quantitative method for the content determination of baicalin in Kangdeling capsule. Methods The chromatography column was Agilent Tc-C18-WR (4.6 mm×250 mm,5 μm),and the column temperature was 30 ℃.The mobile phase c...
Quality control standard for Qingre Baidu granules
XIA Tianyi, ZHANG Bing, GAO Shouhong, LU Wenquan, PIAO Shujuan, PANG Tao
2016, 34(5): 450-454. doi: 10.3969/j.issn.1006-0111.2016.05.018
Abstract:
Objective To establish a quality control standard for Qingre Baidu granules. Methods Isatidis Radix, Fructus Forsythiae,Herba Violae, and Glycyrrhizae were identified by TLC, and the concentration of chlorogenic acid was determined by HPLC. This m...
Study of optimization for the cream base of benzhydramine hydroehloride
SUN Huayan, XU Fenghua, LI Jie, BAI Lin, CAI Le
2016, 34(5): 455-458. doi: 10.3969/j.issn.1006-0111.2016.05.019
Abstract:
Objective To optimize the cream base of benzhydramine hydroehloride. Methods Five nonionic surfactants as an emulsifier were used to prepare benzhydramine hydroehloride creams. The five sorts of cream were evaluated from the appearance,preliminary...
Clinical analysis of 15 patients with Waldenström macroglobulinemia received bortezomib-based treatment
HOU Nan, AN Ran, HOU Jian
2016, 34(5): 459-462. doi: 10.3969/j.issn.1006-0111.2016.05.020
Abstract(3860) PDF (497KB)(492)
Abstract:
Objective To summarize the clinical experience of bortezomib-based treatment for Waldenström macroglobulinemia and evaluate the therapeutic efficacy and safety. Methods The clinical data were collected for 15 patients with Waldenström macroglobuli...
Comparison of the suppressive effect of dezocine,lidocaine and ephedrine on fentanyl-induced cough
WANG Zhi, DONG Yuanhong, CHEN Zhenyi
2016, 34(5): 463-465. doi: 10.3969/j.issn.1006-0111.2016.05.021
Abstract(3907) PDF (402KB)(514)
Abstract:
Objective To evaluate the suppressive effect of dezocine, lidocaine and ephedrine on fentanyl-induced cough. Methods A total of 120 patients ASA I-II, scheduled for elective surgery under general anesthesia, were randomly allocated into four group...
Evaluation and analysis of the rational utilizationofopioids in hospitalized patients with cancer pain in our hospital
NIAN Hua, MA Minghua, XU Yi, WU Tiejun, LIU Jing, XUE Yifan, HAN Keqi, ZHU Quangang
2016, 34(5): 466-468,477. doi: 10.3969/j.issn.1006-0111.2016.05.022
Abstract(3788) PDF (793KB)(848)
Abstract:
Objective To evaluate opioids utilization of cancer ached inpatients in the integrative traditional Chinese and western medicine hospital and provide suggestion for the rational utilization of opioids. Method DDDs,DUI,the distribution of cancer pa...
Research and establishment of antibiotics differentiated indexes in clinical application of cardiothoracic surgery in our hospital
TIAN Tingting, HUANG Aimei, XIE Xiaoyun, SONG Hongtao
2016, 34(5): 469-473. doi: 10.3969/j.issn.1006-0111.2016.05.023
Abstract(3259) PDF (423KB)(471)
Abstract:
Objective To formulate the clinical application specification of antibiotics, make a deference index of antibacterial drugs in chest department according to the investigation about the antibiotics' utility situation in chest department in 2014 and p...
Practice and experience in the participant of the clinical pharmacist in the treatment of cancer pain with renal insufficiency
YI Jia, HOU Xingyun, HUANG Lifeng, CHEN Wansheng
2016, 34(5): 474-477. doi: 10.3969/j.issn.1006-0111.2016.05.024
Abstract(3424) PDF (410KB)(676)
Abstract:
Objective To investigate the effect of clinical pharmacists in the analgesic therapysoas to improve the rational use of analgesic drugs. Methods Clinical pharmacists participated in the formulation of drug therapy plan for the patient of cancer pa...
Application of QCC activities in the efficiency improvements of the inventory management of oral tablets in ward pharmacy
WANG Yawei, YAN Yan, FAN Meihua, CHENG Hongqin
2016, 34(5): 478-480. doi: 10.3969/j.issn.1006-0111.2016.05.025
Abstract:
Objective To enhance oral tablets ward pharmacy inventory efficiency and improve the comprehensive quality of the pharmacist by QCC activities. Method Main factors to extend the ward pharmacy tablet counting time were analyzed through collecting t...