Progress on the anti-tumor activity of seaweed polysaccharides

ZHANG Yue; WANG Jing; LI Tiejun

doi:10.3969/j.issn.1006-0111.2016.05.003

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Seaweed polysaccharides are not only a direct inhibitory effect on tumor cells, but also an indirect therapeutic effected by enhancing immune function or inhibiting tumor cell metastasis. Seaweed polysaccharides could inhibit the growth of tumor cells due to reducing tumor chemotherapy drug resistance and inhibiting free radical generation, accelerating free radical scavenging. Moreover, seaweed polysaccharides have a synergistic effect with chemotherapy drugs to reduce their side effects and protest patients from radiotherapy-induced immune cell damage. Therefore, seaweed polysaccharide could be used as adjuvant therapeutic agents. the antitumor activity and mechanism of seaweed polysaccharides were summarized, covering 28 articles published in the years from 2004 to 2015.

Progress on the anti-tumor activity of seaweed polysaccharides

1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China

2. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2015-12-01

Rev Recd Date: 2016-06-21

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Abstract: Seaweed polysaccharides are not only a direct inhibitory effect on tumor cells, but also an indirect therapeutic effected by enhancing immune function or inhibiting tumor cell metastasis. Seaweed polysaccharides could inhibit the growth of tumor cells due to reducing tumor chemotherapy drug resistance and inhibiting free radical generation, accelerating free radical scavenging. Moreover, seaweed polysaccharides have a synergistic effect with chemotherapy drugs to reduce their side effects and protest patients from radiotherapy-induced immune cell damage. Therefore, seaweed polysaccharide could be used as adjuvant therapeutic agents. the antitumor activity and mechanism of seaweed polysaccharides were summarized, covering 28 articles published in the years from 2004 to 2015.

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Reference (27)

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Progress on the anti-tumor activity of seaweed polysaccharides

doi: 10.3969/j.issn.1006-0111.2016.05.003

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