SHI Hekun, CHEN Kaijie, LIN Xiaofeng, CHEN Jinsan. Effects of Ludisia discolor aqueous extract on exercise capacity, serum lactic acid, urea nitrogen and hepatic glycogen in mice[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 399-402. doi: 10.3969/j.issn.1006-0111.2016.05.005
| Citation:
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SHI Hekun, CHEN Kaijie, LIN Xiaofeng, CHEN Jinsan. Effects of Ludisia discolor aqueous extract on exercise capacity, serum lactic acid, urea nitrogen and hepatic glycogen in mice[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 399-402. doi: 10.3969/j.issn.1006-0111.2016.05.005
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Effects of Ludisia discolor aqueous extract on exercise capacity, serum lactic acid, urea nitrogen and hepatic glycogen in mice
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Department of Pharmacy, No.175 Hospital of PLA/Affiliated Southeast Hospital of Xiamen University, Zhangzhou, 363000 China
- Received Date: 2015-02-27
- Rev Recd Date:
2015-12-24
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Abstract
Objective To investigate the effect against exercise-indused fatigue in mice by aqueous extract of Ludisia discolor and its mechanism. Methods Male mice were randomly divided into five groups including low, middle, high dose groups [aqueous extract of Ludisia discolor at dose of 1.22, 2.44, 4.88 g/(kg·d) respectively], positive control group [aqueous extract of Rhodiola, at dose of 2.34 g/(kg·d)] and control group (distilled water). After intragastric administration for seven days, mice were measured for loading swimming time, and were tested 90 minutes after loading swimming for blood urea nitrogen, blood lactic acid and hepatic glycogen levels. Results The blood urea nitrogen was significantly decreased (P<0.05) in aqueous extract of Ludisia discolor groups, and hepatic glycogen was significantly increased (P<0.05) in a dose-dependent manner. The blood lactic acid was significantly decreased in high dose group, and weight loading swimming time was prolonged (P<0.05). The effects of Ludisia discolor is similar compared to Rhodiola. Conclusion The aqueous extract of Ludisia discolor has anti-fatigue action in mice. The mechanism might be related with the increased glycogen reserves, increased glucose aerobic decomposition, as well as reduced anaerobic glucolysis and reduced protein breakdown.
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