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Volume 34 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(5): 447-449

SUN Yuhan, XU Ziyi, LIAO Jun, ZHANG He, FAN Li, LU Ying. Content measurement of doxorubicin hydrochloride and lonidamine by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(3): 127-130. doi: 10.12206/j.issn.2097-2024.202306043
Citation: JIANG Shuwen, LIU Jieping, XIAO Qiusheng, XIAO Jinbao, SHI Chunshan, SUN Dan, JIANG Zongwen. Determination of baicalin in Kangdeling capsule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 447-449. doi: 10.3969/j.issn.1006-0111.2016.05.017
shu

Determination of baicalin in Kangdeling capsule by HPLC

doi: 10.3969/j.issn.1006-0111.2016.05.017
  • 1.

    Department of 461 Clinic, No. 208 Hospital of PLA, Changchun 130021, China

  • 2.

    Clinic of Navigate Air Force University, Changchun 130022, China

  • Received Date: 2014-12-31
  • Rev Recd Date: 2015-09-28
  • Objective To establish an HPLC quantitative method for the content determination of baicalin in Kangdeling capsule. Methods The chromatography column was Agilent Tc-C18-WR (4.6 mm×250 mm,5 μm),and the column temperature was 30 ℃.The mobile phase consisted of acetonitrile and 0.5‰ phosphoric acid (26:74).The flow rate was 1.0 ml/min, and the detection wavelength was 265 nm. Results The retention time of baicalin was about 16 min. The calibration equation was Y=22 114.67 X-112 836.7(r=0998 8)with good linearity in the range of 5.410-108.2 μg/ml for baicalin. The average recovery was 98.78% while RSD were 0.74%. Conclusion This method is simple, time-saving and accurate which could be used to routine analysis of baicalin in Kangdeling capsule.
  • [1] 陈玉敏,曹 红,路军章,等.HPLC法测定复方竹叶石膏颗粒中野黄芩苷的含量[J].解放军药学学报,2013,29(4): 365-366.
    [2] 李永钦,周井炎,徐辉碧.黄芩苷的抗氧化作用[J].华中理工大学学报,1999,27(4):110-112.
    [3] 王 瑞,李玉娟,毕开顺,等.HP-HPLC法测定解毒直透汤中连翘苷、绿原酸及黄芩苷的含量[J].中药材,2004,24(4):287-288.
    [4] 李守拙,李沈明,范书泽.黄芩茎叶中野黄芩苷含量测定[J].中国医药杂志,2008,6(5):40-41.
    [5] 舒德忠,郑小敏,胜明智.高效液相色谱法测定消炎止咳糖浆中黄芩苷的含量[J].中国药师,2008,11(8):947-948.
    [6] 薛黎明,秦雪梅,张丽增.不同产地黄芩药材的黄芩苷含量测定及指纹图谱研究[J].中成药,2008,30(1):10-13.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 21.1 %其他: 21.1 %China: 0.5 %China: 0.5 %United States: 0.2 %United States: 0.2 %[]: 0.2 %[]: 0.2 %上海: 4.9 %上海: 4.9 %北京: 13.0 %北京: 13.0 %张家口: 0.2 %张家口: 0.2 %成都: 0.7 %成都: 0.7 %杭州: 0.5 %杭州: 0.5 %汕头: 0.2 %汕头: 0.2 %洛阳: 0.5 %洛阳: 0.5 %石家庄: 0.2 %石家庄: 0.2 %芒廷维尤: 30.0 %芒廷维尤: 30.0 %西宁: 23.8 %西宁: 23.8 %西安: 0.2 %西安: 0.2 %达尔斯: 0.2 %达尔斯: 0.2 %运城: 0.5 %运城: 0.5 %长沙: 1.0 %长沙: 1.0 %长治: 0.2 %长治: 0.2 %青岛: 0.5 %青岛: 0.5 %黄冈: 1.0 %黄冈: 1.0 %其他ChinaUnited States[]上海北京张家口成都杭州汕头洛阳石家庄芒廷维尤西宁西安达尔斯运城长沙长治青岛黄冈Highcharts.com
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Determination of baicalin in Kangdeling capsule by HPLC

doi: 10.3969/j.issn.1006-0111.2016.05.017
  • 1. Department of 461 Clinic, No. 208 Hospital of PLA, Changchun 130021, China
  • 2. Clinic of Navigate Air Force University, Changchun 130022, China
  • Received Date: 2014-12-31
  • Rev Recd Date: 2015-09-28

Abstract: Objective To establish an HPLC quantitative method for the content determination of baicalin in Kangdeling capsule. Methods The chromatography column was Agilent Tc-C18-WR (4.6 mm×250 mm,5 μm),and the column temperature was 30 ℃.The mobile phase consisted of acetonitrile and 0.5‰ phosphoric acid (26:74).The flow rate was 1.0 ml/min, and the detection wavelength was 265 nm. Results The retention time of baicalin was about 16 min. The calibration equation was Y=22 114.67 X-112 836.7(r=0998 8)with good linearity in the range of 5.410-108.2 μg/ml for baicalin. The average recovery was 98.78% while RSD were 0.74%. Conclusion This method is simple, time-saving and accurate which could be used to routine analysis of baicalin in Kangdeling capsule.

SUN Yuhan, XU Ziyi, LIAO Jun, ZHANG He, FAN Li, LU Ying. Content measurement of doxorubicin hydrochloride and lonidamine by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(3): 127-130. doi: 10.12206/j.issn.2097-2024.202306043
Citation: JIANG Shuwen, LIU Jieping, XIAO Qiusheng, XIAO Jinbao, SHI Chunshan, SUN Dan, JIANG Zongwen. Determination of baicalin in Kangdeling capsule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 447-449. doi: 10.3969/j.issn.1006-0111.2016.05.017
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