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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(5): 450-454

XIA Tianyi, ZHANG Bing, GAO Shouhong, LU Wenquan, PIAO Shujuan, PANG Tao. Quality control standard for Qingre Baidu granules[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 450-454. doi: 10.3969/j.issn.1006-0111.2016.05.018
Citation: XIA Tianyi, ZHANG Bing, GAO Shouhong, LU Wenquan, PIAO Shujuan, PANG Tao. Quality control standard for Qingre Baidu granules[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 450-454. doi: 10.3969/j.issn.1006-0111.2016.05.018
shu

Quality control standard for Qingre Baidu granules

doi: 10.3969/j.issn.1006-0111.2016.05.018
  • 1.

    Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China

  • 2.

    Pharmacy of Clinic, Retired Navy Officer Home, Shuidian Road, Shanghai 200083, China

  • Received Date: 2015-03-06
  • Rev Recd Date: 2015-06-28
  • Objective To establish a quality control standard for Qingre Baidu granules. Methods Isatidis Radix, Fructus Forsythiae,Herba Violae, and Glycyrrhizae were identified by TLC, and the concentration of chlorogenic acid was determined by HPLC. This method was employed on an Agilent ZORBAX SB-C18 column (4.6 mm×250 mm, 5 μm) at 30℃ with a mobile phase of acetonitrile (A) and 0.2% formic acid (B) using the gradient elution program shown as follows: 0-12 min, 11%-12% A run at the flow rate of 1.0 ml/min. The injection volume was 20 μl and the detection wavelength was 327 nm. Results Characteristic spots could be detected by TLC and the specificity of the method was satisfactory. As for chlorogenic acid, the equation of linear regression of chlorogenic acid was Y=60.239 4X+9.096 3 (r=0.999 9) with the linear range of 6.19-396.00 μg/ml. The average recovery was 99.66% (RSD=2.82%). Conclusion The established method is simple, reliable, reproducible, and can be used for the quantitative determination and quality control of Qingre Baidu granules.
  • [1] 汤迎爽, 李富军. 浅议军队医院制剂发展方向[J]. 中医药导报, 2012,18(7):120-121.
    [2] 周苏萍, 夏晓东, 傅小英. 军队药品制剂抽验质量分析与建议[J]. 解放军药学学报, 2010,26(2):176-177.
    [3] 黄立峰, 宋洪涛. 目前形势下医院制剂在大型军队医院中的存在与发展[J]. 解放军药学学报, 2006, 22(1): 77-79.
    [4] 李 霞, 杨颖博, 李君丽, 等. HPLC法同时测定皱皮木瓜中原儿茶酸和绿原酸的含量[J]. 中国医药导报, 2012, 9(34):110-112.
    [5] 赵金娟, 戴雪梅, 曲永胜, 等. 绿原酸药效学研究进展[J]. 中国野生植物资源, 2013, 32(4):1-5.
    [6] 吴卫华, 康 桢, 欧阳冬生, 等. 绿原酸的药理学研究进展[J]. 天然产物研究与开发, 2006, 18:691-694.
    [7] 王丽萍, 郭 栋, 王 果, 等. 中药绿原酸的研究进展[J]. 时珍国医国药, 2011, 22(4):961-963.
    [8] Cai Y, Zhang ZH, Jiang SS, et al. Chlorogenic acid increased acrylamide formation through promotion of HMF formation and 3-aminopropionamide deamination[J]. J Hazard Mater, 2014, 268:1-5.
    [9] Francisco V, Costa G, Figueirinha A, et al. Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid [J]. J Ethnopharmacol, 2013, 148(1):126-134.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 24.4 %其他: 24.4 %其他: 0.3 %其他: 0.3 %China: 1.1 %China: 1.1 %[]: 0.8 %[]: 0.8 %上海: 7.5 %上海: 7.5 %九江: 0.3 %九江: 0.3 %佛山: 0.3 %佛山: 0.3 %北京: 13.6 %北京: 13.6 %南京: 0.8 %南京: 0.8 %台州: 0.3 %台州: 0.3 %吉隆坡: 0.3 %吉隆坡: 0.3 %哈尔滨: 0.6 %哈尔滨: 0.6 %天津: 0.3 %天津: 0.3 %安阳: 0.3 %安阳: 0.3 %张家口: 0.8 %张家口: 0.8 %成都: 0.8 %成都: 0.8 %武汉: 0.3 %武汉: 0.3 %淄博: 0.3 %淄博: 0.3 %渭南: 0.3 %渭南: 0.3 %盐城: 0.3 %盐城: 0.3 %石家庄: 0.6 %石家庄: 0.6 %芒廷维尤: 24.7 %芒廷维尤: 24.7 %西宁: 17.5 %西宁: 17.5 %西安: 0.3 %西安: 0.3 %达州: 0.3 %达州: 0.3 %运城: 0.6 %运城: 0.6 %通化: 0.3 %通化: 0.3 %郑州: 1.1 %郑州: 1.1 %长治: 0.3 %长治: 0.3 %黄冈: 1.1 %黄冈: 1.1 %其他其他China[]上海九江佛山北京南京台州吉隆坡哈尔滨天津安阳张家口成都武汉淄博渭南盐城石家庄芒廷维尤西宁西安达州运城通化郑州长治黄冈Highcharts.com

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Quality control standard for Qingre Baidu granules

doi: 10.3969/j.issn.1006-0111.2016.05.018
  • 1. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China
  • 2. Pharmacy of Clinic, Retired Navy Officer Home, Shuidian Road, Shanghai 200083, China
  • Received Date: 2015-03-06
  • Rev Recd Date: 2015-06-28

Abstract: Objective To establish a quality control standard for Qingre Baidu granules. Methods Isatidis Radix, Fructus Forsythiae,Herba Violae, and Glycyrrhizae were identified by TLC, and the concentration of chlorogenic acid was determined by HPLC. This method was employed on an Agilent ZORBAX SB-C18 column (4.6 mm×250 mm, 5 μm) at 30℃ with a mobile phase of acetonitrile (A) and 0.2% formic acid (B) using the gradient elution program shown as follows: 0-12 min, 11%-12% A run at the flow rate of 1.0 ml/min. The injection volume was 20 μl and the detection wavelength was 327 nm. Results Characteristic spots could be detected by TLC and the specificity of the method was satisfactory. As for chlorogenic acid, the equation of linear regression of chlorogenic acid was Y=60.239 4X+9.096 3 (r=0.999 9) with the linear range of 6.19-396.00 μg/ml. The average recovery was 99.66% (RSD=2.82%). Conclusion The established method is simple, reliable, reproducible, and can be used for the quantitative determination and quality control of Qingre Baidu granules.

XIA Tianyi, ZHANG Bing, GAO Shouhong, LU Wenquan, PIAO Shujuan, PANG Tao. Quality control standard for Qingre Baidu granules[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 450-454. doi: 10.3969/j.issn.1006-0111.2016.05.018
Citation: XIA Tianyi, ZHANG Bing, GAO Shouhong, LU Wenquan, PIAO Shujuan, PANG Tao. Quality control standard for Qingre Baidu granules[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 450-454. doi: 10.3969/j.issn.1006-0111.2016.05.018
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