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LIU Jing, XU Yi, XU Lingling, WU Tiejun, HUANG Jin. Prokineticin 2 mediates peripheral and central sensitization of somatic pain[J]. Journal of Pharmaceutical Practice and Service, 2021, 39(5): 395-398. doi: 10.12206/j.issn.1006-0111.202103006
Citation: HOU Nan, AN Ran, HOU Jian. Clinical analysis of 15 patients with Waldenström macroglobulinemia received bortezomib-based treatment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 459-462. doi: 10.3969/j.issn.1006-0111.2016.05.020

Clinical analysis of 15 patients with Waldenström macroglobulinemia received bortezomib-based treatment

doi: 10.3969/j.issn.1006-0111.2016.05.020
  • Received Date: 2016-05-18
  • Rev Recd Date: 2016-07-18
  • Objective To summarize the clinical experience of bortezomib-based treatment for Waldenström macroglobulinemia and evaluate the therapeutic efficacy and safety. Methods The clinical data were collected for 15 patients with Waldenström macroglobulinemia receiving bortezomib-based treatment from December 2008 to October 2015.Three therapeutic regimens included BD (bortezomib and dexamethasone) in one case, RBD (bortezomib, rituximab and dexamethasone) in three cases and BCD (bortezomib, dexamethasone and cyclophosphamide) in eleven cases.Responses, adverse reactions and survival analysis were evaluated respectively. Results The overall response rate and major response rate were 93.3% and 80% including CR 1 case, VGPR 2 cases, PR 9 cases and MR 2 cases. The common adverse events included gastrointestinal (53.3%), leukopenia (20%), infection (20%) and peripheral neuropathy (26.7%). After a median follow-up of 21 (3-85) months, the median PFS (progression-free survival) time was 21 (3-36) months and 1 year PFS rate was 83.3%. Survival analysis showed that two prognostic risk factors related to PFS were high-risk group based on international prognostic scoring system for WM(IPSSWM)(P=0.015) and the low response to treatment (P=0.024). Conclusion Bortezomib-based therapeutic regimensexhibited significant efficacyfor patients with WM. IPSSWM and the responses to treatment can be usedto monitor the disease progression and evaluate the therapeutic result.
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Clinical analysis of 15 patients with Waldenström macroglobulinemia received bortezomib-based treatment

doi: 10.3969/j.issn.1006-0111.2016.05.020

Abstract: Objective To summarize the clinical experience of bortezomib-based treatment for Waldenström macroglobulinemia and evaluate the therapeutic efficacy and safety. Methods The clinical data were collected for 15 patients with Waldenström macroglobulinemia receiving bortezomib-based treatment from December 2008 to October 2015.Three therapeutic regimens included BD (bortezomib and dexamethasone) in one case, RBD (bortezomib, rituximab and dexamethasone) in three cases and BCD (bortezomib, dexamethasone and cyclophosphamide) in eleven cases.Responses, adverse reactions and survival analysis were evaluated respectively. Results The overall response rate and major response rate were 93.3% and 80% including CR 1 case, VGPR 2 cases, PR 9 cases and MR 2 cases. The common adverse events included gastrointestinal (53.3%), leukopenia (20%), infection (20%) and peripheral neuropathy (26.7%). After a median follow-up of 21 (3-85) months, the median PFS (progression-free survival) time was 21 (3-36) months and 1 year PFS rate was 83.3%. Survival analysis showed that two prognostic risk factors related to PFS were high-risk group based on international prognostic scoring system for WM(IPSSWM)(P=0.015) and the low response to treatment (P=0.024). Conclusion Bortezomib-based therapeutic regimensexhibited significant efficacyfor patients with WM. IPSSWM and the responses to treatment can be usedto monitor the disease progression and evaluate the therapeutic result.

LIU Jing, XU Yi, XU Lingling, WU Tiejun, HUANG Jin. Prokineticin 2 mediates peripheral and central sensitization of somatic pain[J]. Journal of Pharmaceutical Practice and Service, 2021, 39(5): 395-398. doi: 10.12206/j.issn.1006-0111.202103006
Citation: HOU Nan, AN Ran, HOU Jian. Clinical analysis of 15 patients with Waldenström macroglobulinemia received bortezomib-based treatment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 459-462. doi: 10.3969/j.issn.1006-0111.2016.05.020
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