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DING Huamin, GUO Yuchen, QIN Chunxia, SONG Zhibing, SUN Lili. Therapeutic effect of Xiaofeng Zhiyang granules on acute itching in mice with atopic dermatitis by decreasing leukotriene[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
Citation:
WANG Zhi, DONG Yuanhong, CHEN Zhenyi. Comparison of the suppressive effect of dezocine,lidocaine and ephedrine on fentanyl-induced cough[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 463-465. doi: 10.3969/j.issn.1006-0111.2016.05.021
Comparison of the suppressive effect of dezocine,lidocaine and ephedrine on fentanyl-induced cough
Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China
Received Date: 2015-10-07
Rev Recd Date:
2016-05-03
Abstract
Objective To evaluate the suppressive effect of dezocine, lidocaine and ephedrine on fentanyl-induced cough. Methods A total of 120 patients ASA I-II, scheduled for elective surgery under general anesthesia, were randomly allocated into four groups (n=30, each group). Group Ⅰ,Ⅱ,Ⅲ, Ⅳ were given saline (2 ml), dezocine (0.1 mg/kg), lidocaine(1 mg/kg) or ephedrine(5 mg), respectively. One minute later all patients were injected with 4 μg/kg of fentanyl, after another one minute, all patients were given midazolam(0.1 mg/kg)+ propofol(2 mg/kg,0.4 ml/s)+cisatracurium (0.2 mg/kg). The incidence rate and severity of cough were recorded and hemodynamic parameters were also observed. Results The incidence rate of cough was 50%, 16.7%, 13.3% and 20% for group Ⅰ,Ⅱ,Ⅲ and Ⅳ, respectively. Comparing to group I, the incidence rate of cough was significantly lower (P<0.05) in other groups, but among the three experimental groups there was no significant difference in cough incidence rate and intensity. The hemodynamic changed of each group before and after the induction was consistent. Conclusion A priming dose of dezocine(0.1 mg/kg), lidocaine (1 mg/kg) or ephedrine (5 mg) could effectively reduce the Fentanyl-induced cough response.
Agarwal A, Azim A, Ambesh S, et al. Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl [J]. Can J Anesth, 2003,50(3) : 297-300.
[2]
Lin CS, Sun WZ, Chan WH, et al. Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough [J]. Can J Anaesth, 2004, 51 (7) :654- 659.
[3]
Pandey CK, Raza M, Ranjan R, et al. Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough [J]. Can J Anaesth, 2005, 52(2) :172- 175.
[4]
Sun ZT,Yang CY,Zhang J,et al.Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia inducition:a double-blinded, prospective,randomized,controlled trial [J].J Anesth,2011,25 (6):860-863.
[5]
Tweed WA,Dakin D.Explosive coughing after bolus fentanyl injection[J].Anesth Analg,2001,92(6):1442-1443.
[6]
Lou YP.Regulation of neuropeptide release from pulmonary capsaicin-sensitive aferents in relation to bronchoconstriction [J].Acta Physiol Scand,1993,612:1-88.
[7]
Tanaka M,Maruyama K. Mechanisms of capsaicin- and citric-acid-induced cough reflexes in gunnea pigs [J].J Pharm Sci,2005,99 (1):77-82.
[8]
Ai Q,Hu Y,Wang Y, et a1. Pentazocine pretreatment suppresses fentanyl -induced cough [J]. Pharmacol Rep,2010,62 (4):747-750.
[9]
Hung KC.The possible mechanism of clonidie to suppress fentanyl-induced coughing[J].Acta Anaesthesiol Scand, 2009,53 (9): 1227-1228.
[10]
Karlsson JA,Lanner AS,Persson CG.Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs[J].J Pharmacol Exper Therap,1990,252 (2):863.
Xu YJ,Zhu Y, Wang SL,et al.Dezocine attenuates fentanyl-induced cough in a dose-dependent manner-a randomized controlled trial [ J ].Int J Clin Eexp Med,2015,8(4):6091-6096.
[13]
EL Baissari MC,Taha SK,Siddik-Sayyid SM,et al. Fentanyl-induced cough-pathophysiology and prevention[J]. Middle East J Anesthesiol, 2014,22(5):449-456.
Abstract: Objective To evaluate the suppressive effect of dezocine, lidocaine and ephedrine on fentanyl-induced cough. Methods A total of 120 patients ASA I-II, scheduled for elective surgery under general anesthesia, were randomly allocated into four groups (n=30, each group). Group Ⅰ,Ⅱ,Ⅲ, Ⅳ were given saline (2 ml), dezocine (0.1 mg/kg), lidocaine(1 mg/kg) or ephedrine(5 mg), respectively. One minute later all patients were injected with 4 μg/kg of fentanyl, after another one minute, all patients were given midazolam(0.1 mg/kg)+ propofol(2 mg/kg,0.4 ml/s)+cisatracurium (0.2 mg/kg). The incidence rate and severity of cough were recorded and hemodynamic parameters were also observed. Results The incidence rate of cough was 50%, 16.7%, 13.3% and 20% for group Ⅰ,Ⅱ,Ⅲ and Ⅳ, respectively. Comparing to group I, the incidence rate of cough was significantly lower (P<0.05) in other groups, but among the three experimental groups there was no significant difference in cough incidence rate and intensity. The hemodynamic changed of each group before and after the induction was consistent. Conclusion A priming dose of dezocine(0.1 mg/kg), lidocaine (1 mg/kg) or ephedrine (5 mg) could effectively reduce the Fentanyl-induced cough response.
DING Huamin, GUO Yuchen, QIN Chunxia, SONG Zhibing, SUN Lili. Therapeutic effect of Xiaofeng Zhiyang granules on acute itching in mice with atopic dermatitis by decreasing leukotriene[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
Citation:
WANG Zhi, DONG Yuanhong, CHEN Zhenyi. Comparison of the suppressive effect of dezocine,lidocaine and ephedrine on fentanyl-induced cough[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 463-465. doi: 10.3969/j.issn.1006-0111.2016.05.021
Agarwal A, Azim A, Ambesh S, et al. Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl [J]. Can J Anesth, 2003,50(3) : 297-300.
[2]
Lin CS, Sun WZ, Chan WH, et al. Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough [J]. Can J Anaesth, 2004, 51 (7) :654- 659.
[3]
Pandey CK, Raza M, Ranjan R, et al. Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough [J]. Can J Anaesth, 2005, 52(2) :172- 175.
[4]
Sun ZT,Yang CY,Zhang J,et al.Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia inducition:a double-blinded, prospective,randomized,controlled trial [J].J Anesth,2011,25 (6):860-863.
[5]
Tweed WA,Dakin D.Explosive coughing after bolus fentanyl injection[J].Anesth Analg,2001,92(6):1442-1443.
[6]
Lou YP.Regulation of neuropeptide release from pulmonary capsaicin-sensitive aferents in relation to bronchoconstriction [J].Acta Physiol Scand,1993,612:1-88.
[7]
Tanaka M,Maruyama K. Mechanisms of capsaicin- and citric-acid-induced cough reflexes in gunnea pigs [J].J Pharm Sci,2005,99 (1):77-82.
[8]
Ai Q,Hu Y,Wang Y, et a1. Pentazocine pretreatment suppresses fentanyl -induced cough [J]. Pharmacol Rep,2010,62 (4):747-750.
[9]
Hung KC.The possible mechanism of clonidie to suppress fentanyl-induced coughing[J].Acta Anaesthesiol Scand, 2009,53 (9): 1227-1228.
[10]
Karlsson JA,Lanner AS,Persson CG.Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs[J].J Pharmacol Exper Therap,1990,252 (2):863.
Xu YJ,Zhu Y, Wang SL,et al.Dezocine attenuates fentanyl-induced cough in a dose-dependent manner-a randomized controlled trial [ J ].Int J Clin Eexp Med,2015,8(4):6091-6096.
[13]
EL Baissari MC,Taha SK,Siddik-Sayyid SM,et al. Fentanyl-induced cough-pathophysiology and prevention[J]. Middle East J Anesthesiol, 2014,22(5):449-456.
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DING Huamin, GUO Yuchen, QIN Chunxia, SONG Zhibing, SUN Lili. Therapeutic effect of Xiaofeng Zhiyang granules on acute itching in mice with atopic dermatitis by decreasing leukotriene[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
DING Huamin, GUO Yuchen, QIN Chunxia, SONG Zhibing, SUN Lili. Therapeutic effect of Xiaofeng Zhiyang granules on acute itching in mice with atopic dermatitis by decreasing leukotriene[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
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