Preparation and application of micro gels in sustained and controlled release drug delivery systems

LI Peiyao; HUANG Yueying; LI Chuanling; BIAN Jun

doi:10.3969/j.issn.1006-0111.2019.03.004

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2019 > 37(3): 212-215,221

LI Peiyao, HUANG Yueying, LI Chuanling, BIAN Jun. Preparation and application of micro gels in sustained and controlled release drug delivery systems[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 212-215,221. doi: 10.3969/j.issn.1006-0111.2019.03.004

Citation:

LI Peiyao, HUANG Yueying, LI Chuanling, BIAN Jun. Preparation and application of micro gels in sustained and controlled release drug delivery systems[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 212-215,221. doi: 10.3969/j.issn.1006-0111.2019.03.004

Preparation and application of micro gels in sustained and controlled release drug delivery systems

doi: 10.3969/j.issn.1006-0111.2019.03.004

1.
Department of Pharmacy, Hongkou Branch, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200434, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2.
Department of Pharmacy, Hongkou Branch, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200434, China

Received Date: 2018-08-14
Rev Recd Date: 2018-10-15

Abstract

Micro gels are functional polymer with intramolecular crosslinked network structure and particle size between 0.1 and 100 μm.Micro gels have the characteristics of small particle size,high drug loading,and good environmental responsiveness and biocompatibility,which has unique advantages in the application of drug controlled release systems.A brief introduction in characteristics,preparation methods,preparation materials and applications of micro gels in drug controlled release systems was given in this review.
- micro gels,
- physicochemical properties,
- preparation methods,
- sustained and controlled release drug delivery system

References

[1]	LU B,TARN M D,PAMME N,et al. Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release[J].Journal of Polymer Science Part A:Polymer Chemistry,2017,56(1):59-66.
[2]	武永皓.响应性聚合物的组装及响应性微凝胶的应用[D].中国科学技术大学,2012.
[3]	李宝.基于聚醚胺智能微凝胶在染料分离中的应用[D].上海交通大学,2013.
[4]	吴行才,韩大匡,卢祥国,等.微凝胶颗粒水分散液体系在多孔介质中的驱替机理[J].地球科学-中国地质大学学报,2017,42(8):1348-1355.
[5]	WANG Y,XU J,MUKKAMALA R.New and stable aqueous hybrid binder:US,US 20140256871 A1[P].2014.
[6]	ALHURAISHAWY A K,BAI B,WEI M.Combined ionically modified seawater and microgels to improve oil recovery in fractured carbonate reservoirs[J].Journal of Petroleum Science and Engineering,2018,162:434-445.
[7]	DUFFY C,O'SULLIVAN M,JACQUIER J C.Preparation of novel chitosan iron microgel beads for fortification applications[J].Food Hydrocolloids,2018,84:608-615.
[8]	WU Q,WANG X,LIAO C,et al. Microgel coating of magnetic nanoparticles via bienzyme-mediated free-radical polymerization for colorimetric detection of glucose[J].Nanoscale,2015,7(40):16578-16582.
[9]	KEIDEL R,GHAVAMI A,LUGO DM,et al. Time-resolved structural evolution during the collapse of responsive hydrogels:The microgel-to-particle transition[J].Sci Adv,2018,4(4):eaao7086.
[10]	王平,杨巧凤,赵传壮.光响应性微凝胶的分子设计和智能材料构筑[J].化学进展,2017,v.29; No.20707:750-756.
[11]	殷磊.PEG接枝巯基化壳聚糖微凝胶的黏附性及其促渗性研究[D].武汉理工大学,2009.
[12]	任淑萍,周芳名,常成明.温敏性微凝胶的合成[J].当代化工,2015,44(12):2773-2774.
[13]	张拥军,关英,罗巧芳,等.PNIPAM温敏微凝胶在生物医学领域中的应用研究[J].高分子通报,2013(01):26-39.
[14]	姜帅,李媛媛,赵畅,等.微凝胶在食品中的应用及研究进展[J].食品工业科技,2016,37(22):365-368.
[15]	DESTRIBATS M,LAPEYRE V,SELLIER E, et al. Water-in-oil emulsions stabilized by water-dispersible poly(N-isopropylacrylamide) microgels:understanding anti-Finkle behavior[J].Langmuir,2011,27(23):14096-14107.
[16]	PLAMPER F A,RICHTERING W.Functional microgels and microgel systems[J].Acc Chem Res,2017,50(2):131-140.
[17]	尹艳镇,刘德敏,焦淑菲,等.聚合物骨架凝胶和微凝胶的研究与展望[J].广州化工,2013,41(10):9-11.
[18]	FUENTES C,CASTILLO J,VILA J,et al. Application of asymmetric flow field-flow fractionation (AF4) and multiangle light scattering (MALS) for the evaluation of changes in the product molar mass during PVP-b-PAMPS synthesis[J].Anal Bioanal Chem,2018,410(16):3757-3767.
[19]	MOHANTY P S,NÖJD S,BERGMAN M J,et al. Dielectric spectroscopy of ionic microgel suspensions.[J].Soft Matter,2016,12(48):9705-9727.
[20]	URREHMAN S,SAHINER M,SEL K,et al. Synthesis and characterization of new microgel from tris(2-aminoethyl)amine and glycerol diglycidyl ether as poly(TAEA-co-GDE).[J].Colloids Surf B Biointerfaces,2015,136:1156-1165.
[21]	LYON L A,MENG Z,SINGH N,et al. Thermoresponsive microgel-based materials.[J].Chem Soc Rev,2009,38(4):865-874.
[22]	王红岩,周铭.微凝胶的制备及其在涂料中的应用[J].上海涂料,2009,47(10):18-21.
[23]	宋晓艳,徐如梦,武佳洁,等.温度及pH响应性水凝胶的制备[J].河南工程学院学报(自然科学版),2018,30(02):32-36.
[24]	樊晓敏.pH响应复合微凝胶合成及凝胶化研究[D].郑州轻工业学院,2018.
[25]	SHARMA B,STRIEGLER S.Crosslinked microgels as platform for hydrolytic catalysts[J].Biomacromolecules,2018,19(4):1164-1174.
[26]	XUE J,ZHANG Z,NIE J,et al. Formation of microgels by utilizing the reactivity of catechols with radicals[J].Macromolecules,2017,50(14):5285-5292.
[27]	TSAI H Y,LEE A,PENG W,et al. Synthesis of poly(N-isopropylacrylamide) particles for metal affinity binding of peptides[J].Colloids Surf B Biointerfaces,2014,114:104-110.
[28]	WOLFF H J M,KATHER M,BREISIG H,et al. From batch to continuous precipitation polymerization of thermoresponsive microgels.[J].ACS Appl Mater Interfaces,2018,10(29):24799-24806.
[29]	FAROOQI Z H,SAKHAWAT T,KHAN S R,et al. Synthesis,characterization and fabrication of copper nanoparticles in N-isopropylacrylamide based co-polymer microgels for degradation of p-nitrophenol[J].Materials Science-Poland,2015,33(1):185-192.
[30]	姚明浩.基于基因工程多肽物理水凝胶的制备及其应用[D].华中科技大学,2016.
[31]	NYSTRÖM L,STRÖMSTEDT A A,SCHMIDTCHEN A,et al. Peptide-loaded microgels as antimicrobial and anti-inflammatory surface coatings[J].Biomacromolecules,2018,19(8):3456-3466.
[32]	SARKAR A,MURRAY B,HOLMES M,et al. In vitro digestion of Pickering emulsions stabilized by soft whey protein microgel particles:influence of thermal treatment[J].Soft Matter,2016,12(15):3558-3569.
[33]	刘阳.几种温敏微凝胶三维组装体的制备和应用研究[D].南开大学,2014.
[34]	杨菊香.微凝胶负载杂多酸季铵盐微反应器的构筑及在深度脱硫中的应用[D].陕西师范大学,2008.
[35]	SUN Q,ZHANG Z,ZHANG R,et al. Development of functional or medical foods for oral administration of insulin for diabetes treatment:gastroprotective edible microgels[J].J Agric Food Chem,2018,66(19):4820-4826.
[36]	LIU L,ZHANG Y,YU S,et al. pH- and Amylase-responsive carboxymethyl starch/poly(2-isobutyl-acrylic acid) hybrid microgels as effective enteric carriers for oral insulin delivery[J].Biomacromolecules,2018,19(6):2123-2136.
[37]	DE KRUIF J K,LEDERGERBER G,GAROFALO C,et al. On prilled nanotubes-in-microgel oral systems for protein delivery[J].Eur J Pharm Biopharm,2016,101:90-102.
[38]	TOWN A R,GIARDIELLO M,GURJAR R,et al. Dual-stimuli responsive injectable microgel/solid drug nanoparticle nanocomposites for release of poorly soluble drugs[J].Nanoscale,2017,9(19):6302-6314.
[39]	董晓明.PLGA-PEG-PLGA温度敏感水凝胶在防粘连及骨髓炎治疗中的应用研究[D].吉林大学,2017.
[40]	WU Y,YAO J,ZHOU J,et al. Enhanced and sustained topical ocular delivery of cyclosporine A in thermosensitive hyaluronic acid-based in situ forming microgels[J].Int J Nanomedicine,2013,8(Issue 1):3587-3601.
[41]	KENECHUKWU F C,ATTAMA A A,IBEZIM E C, et al. Surface-modified mucoadhesive microgels as a controlled release system for miconazole nitrate to improve localized treatment of vulvovaginal candidiasis[J].Eur J Pharm Sci,2018,111:358-375.
[42]	GÓMEZ C,BENITO M,KATIME I, et al. In vitro transdermal and biological evaluation of ALA-loaded poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide-co-acrylic acid) microgels for photodynamic therapy[J].J Microencapsul,2012,29(7):626-635.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Preparation and application of micro gels in sustained and controlled release drug delivery systems

1. Department of Pharmacy, Hongkou Branch, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200434, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

2. Department of Pharmacy, Hongkou Branch, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200434, China

Received Date: 2018-08-14

Rev Recd Date: 2018-10-15

Key words:

micro gels /
physicochemical properties /
preparation methods /
sustained and controlled release drug delivery system

Abstract: Micro gels are functional polymer with intramolecular crosslinked network structure and particle size between 0.1 and 100 μm.Micro gels have the characteristics of small particle size,high drug loading,and good environmental responsiveness and biocompatibility,which has unique advantages in the application of drug controlled release systems.A brief introduction in characteristics,preparation methods,preparation materials and applications of micro gels in drug controlled release systems was given in this review.

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Reference (42)

[1]	LU B,TARN M D,PAMME N,et al. Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release[J].Journal of Polymer Science Part A:Polymer Chemistry,2017,56(1):59-66.
[2]	武永皓.响应性聚合物的组装及响应性微凝胶的应用[D].中国科学技术大学,2012.
[3]	李宝.基于聚醚胺智能微凝胶在染料分离中的应用[D].上海交通大学,2013.
[4]	吴行才,韩大匡,卢祥国,等.微凝胶颗粒水分散液体系在多孔介质中的驱替机理[J].地球科学-中国地质大学学报,2017,42(8):1348-1355.
[5]	WANG Y,XU J,MUKKAMALA R.New and stable aqueous hybrid binder:US,US 20140256871 A1[P].2014.
[6]	ALHURAISHAWY A K,BAI B,WEI M.Combined ionically modified seawater and microgels to improve oil recovery in fractured carbonate reservoirs[J].Journal of Petroleum Science and Engineering,2018,162:434-445.
[7]	DUFFY C,O'SULLIVAN M,JACQUIER J C.Preparation of novel chitosan iron microgel beads for fortification applications[J].Food Hydrocolloids,2018,84:608-615.
[8]	WU Q,WANG X,LIAO C,et al. Microgel coating of magnetic nanoparticles via bienzyme-mediated free-radical polymerization for colorimetric detection of glucose[J].Nanoscale,2015,7(40):16578-16582.
[9]	KEIDEL R,GHAVAMI A,LUGO DM,et al. Time-resolved structural evolution during the collapse of responsive hydrogels:The microgel-to-particle transition[J].Sci Adv,2018,4(4):eaao7086.
[10]	王平,杨巧凤,赵传壮.光响应性微凝胶的分子设计和智能材料构筑[J].化学进展,2017,v.29; No.20707:750-756.
[11]	殷磊.PEG接枝巯基化壳聚糖微凝胶的黏附性及其促渗性研究[D].武汉理工大学,2009.
[12]	任淑萍,周芳名,常成明.温敏性微凝胶的合成[J].当代化工,2015,44(12):2773-2774.
[13]	张拥军,关英,罗巧芳,等.PNIPAM温敏微凝胶在生物医学领域中的应用研究[J].高分子通报,2013(01):26-39.
[14]	姜帅,李媛媛,赵畅,等.微凝胶在食品中的应用及研究进展[J].食品工业科技,2016,37(22):365-368.
[15]	DESTRIBATS M,LAPEYRE V,SELLIER E, et al. Water-in-oil emulsions stabilized by water-dispersible poly(N-isopropylacrylamide) microgels:understanding anti-Finkle behavior[J].Langmuir,2011,27(23):14096-14107.
[16]	PLAMPER F A,RICHTERING W.Functional microgels and microgel systems[J].Acc Chem Res,2017,50(2):131-140.
[17]	尹艳镇,刘德敏,焦淑菲,等.聚合物骨架凝胶和微凝胶的研究与展望[J].广州化工,2013,41(10):9-11.
[18]	FUENTES C,CASTILLO J,VILA J,et al. Application of asymmetric flow field-flow fractionation (AF4) and multiangle light scattering (MALS) for the evaluation of changes in the product molar mass during PVP-b-PAMPS synthesis[J].Anal Bioanal Chem,2018,410(16):3757-3767.
[19]	MOHANTY P S,NÖJD S,BERGMAN M J,et al. Dielectric spectroscopy of ionic microgel suspensions.[J].Soft Matter,2016,12(48):9705-9727.
[20]	URREHMAN S,SAHINER M,SEL K,et al. Synthesis and characterization of new microgel from tris(2-aminoethyl)amine and glycerol diglycidyl ether as poly(TAEA-co-GDE).[J].Colloids Surf B Biointerfaces,2015,136:1156-1165.
[21]	LYON L A,MENG Z,SINGH N,et al. Thermoresponsive microgel-based materials.[J].Chem Soc Rev,2009,38(4):865-874.
[22]	王红岩,周铭.微凝胶的制备及其在涂料中的应用[J].上海涂料,2009,47(10):18-21.
[23]	宋晓艳,徐如梦,武佳洁,等.温度及pH响应性水凝胶的制备[J].河南工程学院学报(自然科学版),2018,30(02):32-36.
[24]	樊晓敏.pH响应复合微凝胶合成及凝胶化研究[D].郑州轻工业学院,2018.
[25]	SHARMA B,STRIEGLER S.Crosslinked microgels as platform for hydrolytic catalysts[J].Biomacromolecules,2018,19(4):1164-1174.
[26]	XUE J,ZHANG Z,NIE J,et al. Formation of microgels by utilizing the reactivity of catechols with radicals[J].Macromolecules,2017,50(14):5285-5292.
[27]	TSAI H Y,LEE A,PENG W,et al. Synthesis of poly(N-isopropylacrylamide) particles for metal affinity binding of peptides[J].Colloids Surf B Biointerfaces,2014,114:104-110.
[28]	WOLFF H J M,KATHER M,BREISIG H,et al. From batch to continuous precipitation polymerization of thermoresponsive microgels.[J].ACS Appl Mater Interfaces,2018,10(29):24799-24806.
[29]	FAROOQI Z H,SAKHAWAT T,KHAN S R,et al. Synthesis,characterization and fabrication of copper nanoparticles in N-isopropylacrylamide based co-polymer microgels for degradation of p-nitrophenol[J].Materials Science-Poland,2015,33(1):185-192.
[30]	姚明浩.基于基因工程多肽物理水凝胶的制备及其应用[D].华中科技大学,2016.
[31]	NYSTRÖM L,STRÖMSTEDT A A,SCHMIDTCHEN A,et al. Peptide-loaded microgels as antimicrobial and anti-inflammatory surface coatings[J].Biomacromolecules,2018,19(8):3456-3466.
[32]	SARKAR A,MURRAY B,HOLMES M,et al. In vitro digestion of Pickering emulsions stabilized by soft whey protein microgel particles:influence of thermal treatment[J].Soft Matter,2016,12(15):3558-3569.
[33]	刘阳.几种温敏微凝胶三维组装体的制备和应用研究[D].南开大学,2014.
[34]	杨菊香.微凝胶负载杂多酸季铵盐微反应器的构筑及在深度脱硫中的应用[D].陕西师范大学,2008.
[35]	SUN Q,ZHANG Z,ZHANG R,et al. Development of functional or medical foods for oral administration of insulin for diabetes treatment:gastroprotective edible microgels[J].J Agric Food Chem,2018,66(19):4820-4826.
[36]	LIU L,ZHANG Y,YU S,et al. pH- and Amylase-responsive carboxymethyl starch/poly(2-isobutyl-acrylic acid) hybrid microgels as effective enteric carriers for oral insulin delivery[J].Biomacromolecules,2018,19(6):2123-2136.
[37]	DE KRUIF J K,LEDERGERBER G,GAROFALO C,et al. On prilled nanotubes-in-microgel oral systems for protein delivery[J].Eur J Pharm Biopharm,2016,101:90-102.
[38]	TOWN A R,GIARDIELLO M,GURJAR R,et al. Dual-stimuli responsive injectable microgel/solid drug nanoparticle nanocomposites for release of poorly soluble drugs[J].Nanoscale,2017,9(19):6302-6314.
[39]	董晓明.PLGA-PEG-PLGA温度敏感水凝胶在防粘连及骨髓炎治疗中的应用研究[D].吉林大学,2017.
[40]	WU Y,YAO J,ZHOU J,et al. Enhanced and sustained topical ocular delivery of cyclosporine A in thermosensitive hyaluronic acid-based in situ forming microgels[J].Int J Nanomedicine,2013,8(Issue 1):3587-3601.
[41]	KENECHUKWU F C,ATTAMA A A,IBEZIM E C, et al. Surface-modified mucoadhesive microgels as a controlled release system for miconazole nitrate to improve localized treatment of vulvovaginal candidiasis[J].Eur J Pharm Sci,2018,111:358-375.
[42]	GÓMEZ C,BENITO M,KATIME I, et al. In vitro transdermal and biological evaluation of ALA-loaded poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide-co-acrylic acid) microgels for photodynamic therapy[J].J Microencapsul,2012,29(7):626-635.

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Preparation and application of micro gels in sustained and controlled release drug delivery systems

doi: 10.3969/j.issn.1006-0111.2019.03.004

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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