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ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
Citation:
ZHANG Lingna, ZHANG Minxin, SONG Hongtao. Optimization of the formulation of polyvinyl alcohol-propranolol hydrochloride porous hydrogel by central composite design-response surface method[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 222-225. doi: 10.3969/j.issn.1006-0111.2019.03.006
Optimization of the formulation of polyvinyl alcohol-propranolol hydrochloride porous hydrogel by central composite design-response surface method
No. 900 Hospital of Joint Support Forces, Fuzhou 350000, China
Received Date: 2018-11-14
Rev Recd Date:
2019-01-16
Abstract
Objective To optimize the formulation of polyvinyl alcohol-propranolol hydrochloride porous hydrogel by central composite design-response surface method. Methods The amount of polyvinyl alcohol and chitosan were taken as the investigation factors,the percutaneous cumulative permeation amount in vitro was used as the evaluation index,and the relationship between the investigation index and the investigation factor were described by the multivariate linear model and the nonlinear model.The optimal formulation was determined by plotting the effect surface and the contour map according to the model. Results The quadratic polynomial fitting in the nonlinear model had a higher complex correlation coefficient,r=0.970 2.The porous hydrogel's 12 h cumulative permeation deviation between the predicted value and the theoretical value was 4.32% which was prepared by optimal formulation,and the model had good predictability. Conclusion The central composite design-response surface method was used to optimize the polyvinyl alcohol-propranolol hydrogel formulation,which could realize the simultaneous optimization of multiple indicators.The established model had good predictability and could be used for formulation optimization.
PEPPAS N A,STAUFFER S R.Reinforced uncrosslinked poly(vinyl alcohol) gels produced by cyclic freezing-thawing processes:a short review[J].J Control Rel,1991,16(3):305-310.
[7]
李希明.高含水聚乙烯醇弹性体[J].高分子学报,1989,1(5):519-523.
[8]
YAO L,SWORDS G A.Hydrogels and methods of making and using same[P].USA:6268405.
[9]
ZHANG X,YANG D,NIE J.Chitosan/polyethylene glycol diacrylate films as potential wound dressing material[J].Int J Biol Macromol,2008,43(5):456-462.
Abstract: Objective To optimize the formulation of polyvinyl alcohol-propranolol hydrochloride porous hydrogel by central composite design-response surface method. Methods The amount of polyvinyl alcohol and chitosan were taken as the investigation factors,the percutaneous cumulative permeation amount in vitro was used as the evaluation index,and the relationship between the investigation index and the investigation factor were described by the multivariate linear model and the nonlinear model.The optimal formulation was determined by plotting the effect surface and the contour map according to the model. Results The quadratic polynomial fitting in the nonlinear model had a higher complex correlation coefficient,r=0.970 2.The porous hydrogel's 12 h cumulative permeation deviation between the predicted value and the theoretical value was 4.32% which was prepared by optimal formulation,and the model had good predictability. Conclusion The central composite design-response surface method was used to optimize the polyvinyl alcohol-propranolol hydrogel formulation,which could realize the simultaneous optimization of multiple indicators.The established model had good predictability and could be used for formulation optimization.
ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
Citation:
ZHANG Lingna, ZHANG Minxin, SONG Hongtao. Optimization of the formulation of polyvinyl alcohol-propranolol hydrochloride porous hydrogel by central composite design-response surface method[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 222-225. doi: 10.3969/j.issn.1006-0111.2019.03.006
PEPPAS N A,STAUFFER S R.Reinforced uncrosslinked poly(vinyl alcohol) gels produced by cyclic freezing-thawing processes:a short review[J].J Control Rel,1991,16(3):305-310.
[7]
李希明.高含水聚乙烯醇弹性体[J].高分子学报,1989,1(5):519-523.
[8]
YAO L,SWORDS G A.Hydrogels and methods of making and using same[P].USA:6268405.
[9]
ZHANG X,YANG D,NIE J.Chitosan/polyethylene glycol diacrylate films as potential wound dressing material[J].Int J Biol Macromol,2008,43(5):456-462.
ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
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