Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice
- Received Date: 2008-11-24
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Key words:
- Qizhiweitong granule /
- gastrointestinal function /
- analgesic effect
Abstract: Objective : To investigate the action of Qizhiweitong granule(QZ) on gastrointestinal function and analgesic effect in mice. Methods : Dextran blue-2000 was used as a marker,both its residue left in the stomach and propulsion velocity in the intestine were determined for the evaluation of gastrointestinal function;with acetic acid induced mice writhing response model,analgesic effect of QZ was determined. Results : QZ 1.25 g/kg,2.50 g/kg,5.00 g/kg improved the inhibition of gastric empty and intestinal propulsion induced by both atropine and dopamine.No changes were observed in morphine-induced gastrointestinal disorder mice model.All the three doses exhibited analgesic effect on acetic acid induced mice writhing response model. Conclusion :These results suggest QZ maybe used to improve gastrointestinal function and possessed analgesic effects.
Citation: | Li Yan, Chen Yuan-yuan, Yin Jia, Jiang Hong, Shen Fu-ming. Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 90-93. |