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Volume 27 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(2): 90-93

Li Yan, Chen Yuan-yuan, Yin Jia, Jiang Hong, Shen Fu-ming. Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 90-93.
Citation: Li Yan, Chen Yuan-yuan, Yin Jia, Jiang Hong, Shen Fu-ming. Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 90-93.
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Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice

  • 1.

    Department of Pharmacy, 411th Hospital of PLA, Shanghai 200081, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-11-24
  • Objective : To investigate the action of Qizhiweitong granule(QZ) on gastrointestinal function and analgesic effect in mice. Methods : Dextran blue-2000 was used as a marker,both its residue left in the stomach and propulsion velocity in the intestine were determined for the evaluation of gastrointestinal function;with acetic acid induced mice writhing response model,analgesic effect of QZ was determined. Results : QZ 1.25 g/kg,2.50 g/kg,5.00 g/kg improved the inhibition of gastric empty and intestinal propulsion induced by both atropine and dopamine.No changes were observed in morphine-induced gastrointestinal disorder mice model.All the three doses exhibited analgesic effect on acetic acid induced mice writhing response model. Conclusion :These results suggest QZ maybe used to improve gastrointestinal function and possessed analgesic effects.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice

  • 1. Department of Pharmacy, 411th Hospital of PLA, Shanghai 200081, China
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-11-24

Abstract: Objective : To investigate the action of Qizhiweitong granule(QZ) on gastrointestinal function and analgesic effect in mice. Methods : Dextran blue-2000 was used as a marker,both its residue left in the stomach and propulsion velocity in the intestine were determined for the evaluation of gastrointestinal function;with acetic acid induced mice writhing response model,analgesic effect of QZ was determined. Results : QZ 1.25 g/kg,2.50 g/kg,5.00 g/kg improved the inhibition of gastric empty and intestinal propulsion induced by both atropine and dopamine.No changes were observed in morphine-induced gastrointestinal disorder mice model.All the three doses exhibited analgesic effect on acetic acid induced mice writhing response model. Conclusion :These results suggest QZ maybe used to improve gastrointestinal function and possessed analgesic effects.

Li Yan, Chen Yuan-yuan, Yin Jia, Jiang Hong, Shen Fu-ming. Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 90-93.
Citation: Li Yan, Chen Yuan-yuan, Yin Jia, Jiang Hong, Shen Fu-ming. Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 90-93.
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