乙酰螺旋霉素片的工艺研究
Technological study of acetylspiramycin tablets
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摘要: 目的 筛选乙酰螺旋霉素片最佳处方。方法 考察预胶化淀粉、低取代羟丙基纤维素和吐温-80对乙酰螺旋霉素片的质量影响,并与2种市售乙酰螺旋霉素片作溶出度比较。结果 筛选的最佳处方制备的乙酰螺旋霉素片,体外溶出度大为提高。结论 本法处方合理,工艺简单,适用于工业化生产。Abstract: OBJECTIVE To obtain the optimum prescription of acelylspiramycin tablets.METHODS The effect of CMS-Na,L-HPC,and Tween-80 on the quality of acetylspiramycin tablets were studied.Its dissolvability was determined and compared with those manufactured by two different factories.RESULTS The results showed that acetylspiramycin tablets prepared with this optimum prescription was much better in terms of dissolvability.CONCLUSION The method is reasonable,simple,and prodruction suitable to pharmaceutical factiories.
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Key words:
- acetylspiramycin tablets /
- dissolvability /
- pregelatinized starch /
- L-HPC /
- tween-80
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