鱼腥草注射液的细菌内毒素检查
Bacterial endotoxin test of Houttuynia injection
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摘要: 目的: 建立鱼腥草注射液细菌内毒素检查法。 方法: 按《中国药典》2000年版二部收载的细菌内毒素检查法要求,确定样品最大有效稀释倍数,进行鱼腥草注射液细菌内毒素干扰试验。 结果: 鱼腥草注射液1:2倍稀释用λ为0．5EU／mL鲎试剂检查细菌内毒素存在抑制性干扰,1:4稀释用λ为0．25EU／mL鲎试剂可消除干扰因素,可有效检测该药细菌内毒素。 结论: 鲎试验法可用于鱼腥草注射液细菌内毒素检查,控制热原。Abstract: Objective: To explore a bacterial endotoxin test for Houttuynia cordata injection. Methods: The bacterial endoloxin test was experimented according to the requirement of the second volum of China Pharmacopoeia,2000 edition. Results: The interference factors could be excluded in the Houttuynia cordata diluted to 4 times, the bacterial endotoxin could be determined effectively by 0. 25 EU/mL of TAL. Conclusion: The pyrogen notoxin in Houttuynia cordata injection can be determined by LLA.
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