褶合光谱法考察乳酸环丙沙星与常用注射液的配伍稳定性
Observation of the stability of common injections mixed with ciprofloxacin lactate by convolution spectrometry
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摘要: 目的： 考察室温下8h内乳酸环丙沙星与7种常用注射液的配伍稳定性。 方法： 采用褶合光谱法, 结合外观和pH值检查法, 并以差谱值予以定量表达。 结果： 在8h内乳酸环丙沙星和乳酸钠注射液配伍外观有变化, 其余配伍溶液外观均无变化；pH值较稳定。用褶合光谱法考察结果乳酸环丙沙星与6种常用输液配伍的差谱值均＜10%, 与乳酸钠注射液配伍1～8h的差谱值均大于20%。 结论： 室温8小时内, 除乳酸环丙沙星与乳酸钠注射液不可以配伍使用外, 与其他6种常用输液是可以配伍使用的。Abstract: Objective: To observe the chemical stability of seven common injections mixed with ciprofloxacin lactate at room tem-perature for 8 hours. Methods: The appearance of mixed injection was observed and pH was tested.The convolution spectrometry was used.The results were described quantitatively by subtract spectrometry value. Results: The subtract spectrometry values of ciprofloxa-cin mixed with six infusions were less than 10%.The subtract spectrometry values of ciprofloxacin lactate mixed with sodium lactate in-jection were 1.57%, 31.76%, 26.46%, 22.85% in 2～8hours. Conclusion: At room temperature for 8 hours ciprofloxacin mixed with six infusions can be used, and ciprofloxacin lactate mixed with sodium lactate injection can't be used.
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