葛根素微乳的制备
Preparation of Puerarin by microemulsion drug delivery system
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摘要: 目的: 制备葛根素微乳口服给药系统(PUE-ME)。 方法: 通过溶解度实验、处方配伍实验和伪三元相图的绘制,以乳化时间、色泽为指标,筛选油相、表面活性剂、助表面活性剂的最佳搭配和处方配比。 结果: 葛根素在微乳中的溶解度最高可达77.11 mg/mL。 结论: 所制备的PUE-ME对葛根素增溶效果显著,将为PUE的口服制剂的进一步开发提供依据。Abstract: Objective: To develop a microemulsion drug delivery system of Puerarin(PUE-ME). Methods: Formulation of PUE-ME was screened by solubility experiments,compatibility tests and pseudo-ternary phase diagrams,with the consequence of visual examination as parameter. Results: The maximum drug corporation was 77.11 mg/mL.The formulation was composed of IPM(10%),brij-96V(37.5%),ethanol(37.5%),and water(25%). Conclusion: The formulation of PUE-ME preparation could meet the general requirements of the design.
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Key words:
- puerarin /
- microemulsion /
- solubilization
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