正交设计优化甲磺酸地拉韦啶分散片处方
The formula optimization of delavirdine mesylate dispersible tablets by orthogonal design test
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摘要: 目的: 筛选甲磺酸地拉韦啶薄膜衣分散片的处方并进行制备。 方法: 以崩解时限为指标,采用正交设计实验,对分散片处方进行筛选,并进行体外溶出度考察。 结果: 按优选处方制备的3批分散片外观光洁,均在3 min内完全崩解并通过710μm筛。 结论: 研制的甲磺酸地拉韦啶分散片处方合理、工艺可行,符合分散片的质量要求。Abstract: Objective: To optimize the formula and prepare delavirdine mesylate dispersible tablets. Methods: The formula of delavirdine mesylate dispersible tablet was optimized in term of disintegrating time by orthogonal design test.The dissolution rates of the principal agent in dispersible tablets were determined. Results: The optimized dispersible tablets had fine appearance and disintegrated in 3 min,and the suspension screened through the 710μm mesh.The dissolution rates of the dispersible tablets were similar in 3 bat- ches formulation. Conclusion:: The prepared delavirdine mesylate dispersible tablet was reasonable in formula,feasible in technology and was accorded with the quality standards.
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Key words:
- delavirdine mesylate /
- dispersible tablet /
- dissolution rate in vitro
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