甲磺酸加贝酯排胆总管结石作用的临床观察
Clinical observation of the role of gabexate mesylate in treatment of choledocholithiasis
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摘要: 目的 确定甲磺酸加贝酯的排胆总管结石作用。 方法 通过简单随机分组的方法,将临床病例分为常规治疗组、普通剂量组和大剂量组。常规治疗组作为对照组,普通剂量组和大剂量组作为实验组。用χ2检验法对照各组间非手术排除胆总管结石作用是否存在显著差异。 结果 普通剂量组的非手术排石作用与常规治疗组无显著差异(P>0.05),大剂量组的非手术排石率为51.02%,其作用与常规治疗组和普通剂量组比较均存在显著差异(P<0.01)。 结论 甲磺酸加贝酯具有排胆总管结石作用。Abstract: Objective To confirm the effect of gabexate mesylate on eliminating choledocholithiasis. Methods By simple randomization, the patients were assigned control group (not use gabexate), regular dosage group and high dosage group. The difference between every group on effect of eliminating choledocholithiasis by nonsurgical operation was observed. Results No significant different was found between regular dosage group and control group (P>0.05). There was a significant different between regular dosage group and high dosage group (P<0.05). Conclusion Gabexate mesylate had the effect of eliminating choledocholithiasis.
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Key words:
- gabexate /
- choledocholithiasis /
- sphincter of Oddi
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[1] 彭国林,李兆申. 加贝酯防治急性胰腺炎应用现状[J]. 胰腺病学,2005,5(9):177. [2] 陈伟成,薛 冰,李智成,等. 甲磺酸加贝酯排胆总管结石4例[J].中国临床药学杂志,2007, 16(6):385. [3] 倪泉兴,傅德良,虞先浚,等.加贝酯对金黄地鼠胆囊及Oddi括约肌收缩的影响[J].胰腺病学,2002,2(4):253. [4] 吴叔明,徐 华,戈之铮,等.加贝酯对Oddi括约肌运动的影响[J].中华消化杂志,2004,24(8):464. -
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