摘要:
目的 观察沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效和安全性。 方法 初治老年多发性骨髓瘤患者50例,均给予沙利度胺联合地塞米松治疗,沙利度胺起始剂量50 mg/次,1次/d,口服,根据患者耐受情况逐步增加剂量50 mg,至最大量200 mg/次,1次/日,口服;地塞米松20 mg/次,1次/日,第1~4天,第9~12天,第17~20天,静脉滴注,每28 d为1个疗程。治疗4个疗程后评定疗效。 结果 完全缓解15例,非常好的部分缓解12例,部分缓解13例,病情无变化5例,疾病进展5例,总有效率为80%。治疗过程中出现嗜睡l7例,便秘16例,疲乏16例,血糖升高10例,外周神经炎8例,皮疹3例,对症处理后均可耐受。 结论 沙利度胺联合地塞米松是治疗老年多发性骨髓瘤的有效方法。
Abstract:
Objective To observe the efficiency and safety of thalidomide combined with dexamethasone in elderly patients with multiple myeloma. Methods A total of 50 elderly patients with multiple myeloma in initial treatment were administered thalidomide combined with dexamethasone. Thalidomide was administered at an initial dose of 50 mg once-daily orally followed by gradually increased in 50 mg according to patients' tolerance to a maximum of 200 mg once-daily orally, dexamethasone was administered at 20 mg once-daily IV in 1~4 d, 9~12 d and 17~20 d with 28 d as a course of treatment. The efficiency after 4 courses of treatment eva-luate was evauated. Results Complete remission were in 15 cases, immense partial remission in 12 cases, partial remission in 13 cases, no change in 5 cases and progression of disease in 5 cases. The total effective rate was 80%. During treatment, there were 17 patients suffering from hypersomnia, 16 onstipation, 16 lassitude, 10 increased blood sugar, 8 peripheral neuropathy and 3 rashes. All the patients could tolerant after expectant treatment. Conclusion It could be an effective method of thalidomide combined with dexamethasone in elderly patients with multiple myeloma.
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