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Lox-1—心血管疾病防治的新靶标

李倩 芮耀诚

李倩, 芮耀诚. Lox-1—心血管疾病防治的新靶标[J]. 药学实践与服务, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
引用本文: 李倩, 芮耀诚. Lox-1—心血管疾病防治的新靶标[J]. 药学实践与服务, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
LI Qian, RUI Yaocheng. Lox-1, a new target in cardiovascular disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
Citation: LI Qian, RUI Yaocheng. Lox-1, a new target in cardiovascular disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001

Lox-1—心血管疾病防治的新靶标

doi: 10.3969/j.issn.1006-0111.2014.05.001

Lox-1, a new target in cardiovascular disease

  • 摘要: 目的 Lox-1(血凝素样氧化低密度脂蛋白受体1),是ox-LDL的主要受体之一,在血管内皮功能障碍、泡沫细胞形成及动脉粥样硬化斑块的稳定性中具有重要作用。 方法 为了探讨Lox-1在心血管疾病中的作用,笔者对有关Lox-1在心血管疾病中的研究进展进行回顾性分析。 结果 Lox-1作为ox-LDL新型清道夫受体,在心血管疾病的发生发展中具有重要的作用。 结论 Lox-1可能为防治心血管疾病的药物研究提供新的思路。
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    [7] Chen XP, Zhang TT, Du GH. Lectin-like oxidized low-density Lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis[J]. Cardiovas Drug Rev, 2007, 25(2):146-161.
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    [12] Xu SW, Ogura S, Chen JW, et al. Lox-1 in atherosclerosis:biological functions and pharmacological modifiers[J]. Cell Mol Life Sci, 2013, 70(6):2859-2872.
    [13] Matarazzo S, Quitadamo MC, Mango R, et al. Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption[J]. Mol Pharmacol, 2012, 82(2):246-254.
    [14] Mehta JL, Chen J, Yu F, et al. Aspirin inhibits ox-LDL mediated Lox-1 expression and metalloproteinase-1 in human coronary endothelial cells[J]. Cardiovasc Res, 2004, 64(2):243-249.
    [15] Chen JW, Zhou SB, Tan ZM. Aspirin and pravastatin reduce lectin-like oxidized low density lipoprotein receptor-1 expression, adhesion molecules and oxidative stress in human coronary artery endothelial cells[J]. Chin Med J, 2010, 123(12):1553-1556.
    [16] Pang T, Wang J, Benicky J, et al. Minocycline ameliorates lps-induced inflammation in human monocytes by novel mechanisms including Lox-1,nur77 and litaf inhibition[J]. Biochim Biophys Acta, 2012, 1820(4):503-510.
    [17] Li L, Renier G. The oral anti-diabetic agent, gliclazide, inhibits oxidized ldl-mediated lox-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells[J]. Atherosclerosis, 2009, 204(1):40-46.
    [18] Xu S, Liu Z, Huang Y, et al. Tanshinone Ⅱ-A inhibits oxidized LDL induced Lox-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation[J]. Transl Res, 2012, 160(2):114-124.
    [19] Kang BY, Khan JA, Ryu S, et al. Curcumin reduces angiotensin Ⅱ-mediated cardiomyocyte growth via Lox-1 inhibition[J]. J Cardiovasc Pharmacol, 2010, 55(2):176-183.
    [20] Guan S, Wang B, Li W, et al. Effects of berberine on expression of Lox-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL[J]. Am J Chin Med, 2010, 38(6):1161-1169.
    [21] Lee WJ,Ou HC, Chou MM, et al. Ellagic acid inhibits oxidized LDL-mediated Lox-1 expression, ROS generation, and inflammation in human endothelial cells[J]. J Vasc Surg, 2010, 52(5):1290-1300.
    [22] Ou HC, Song TY, Yeh YC, et al. EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting Lox-1-mediated signaling[J]. J Appl Physiol, 2010, 108(6):1745-1756.
    [23] Chang HC, Chen TG, Tai YT, et al. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells[J]. J Cereb Blood Flow Metab, 2011, 31(3):842-854.
    [24] Taye A, Saad AH, Kumar AH, et al. Effect of apocynin on NADPH oxidase-mediated oxidative stress-Lox-1-eNOS pathway in human endothelial cells exposed to high glucose[J]. Eur J Pharmacol, 2010, 627(1-3):42-48.
    [25] Lee MJ, Lee HS, Park SD, et al. Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and TNF-alpha induced expression of adhesion molecules and lectin-like oxidized LDL receptor-1 in human umbilical vein endothelial cells[J]. Biosci Biotechnol Biochem, 2010, 74(2):279-284.
    [26] Shibata Y, Kume N, Arai H, et al. Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation and lectin-like oxidized LDL receptor-1(Lox-1) expression in vascular endothelial cells[J]. Atherosclerosis, 2007, 193(1):20-27.
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  • 收稿日期:  2013-02-27
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Lox-1—心血管疾病防治的新靶标

doi: 10.3969/j.issn.1006-0111.2014.05.001

摘要: 目的 Lox-1(血凝素样氧化低密度脂蛋白受体1),是ox-LDL的主要受体之一,在血管内皮功能障碍、泡沫细胞形成及动脉粥样硬化斑块的稳定性中具有重要作用。 方法 为了探讨Lox-1在心血管疾病中的作用,笔者对有关Lox-1在心血管疾病中的研究进展进行回顾性分析。 结果 Lox-1作为ox-LDL新型清道夫受体,在心血管疾病的发生发展中具有重要的作用。 结论 Lox-1可能为防治心血管疾病的药物研究提供新的思路。

English Abstract

李倩, 芮耀诚. Lox-1—心血管疾病防治的新靶标[J]. 药学实践与服务, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
引用本文: 李倩, 芮耀诚. Lox-1—心血管疾病防治的新靶标[J]. 药学实践与服务, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
LI Qian, RUI Yaocheng. Lox-1, a new target in cardiovascular disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
Citation: LI Qian, RUI Yaocheng. Lox-1, a new target in cardiovascular disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
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