The extraction and acute toxicity testing of Moringa oleifera leaves and seeds
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摘要: 目的 测试辣木叶和种子的急性毒性以及安全剂量范围。 方法 参照《中药药理研究方法学》设计实验，确定中药新药的最大耐受量和急性毒性。 结果 小鼠对辣木叶超微粉和辣木叶醇提物的最大耐受量分别为0.4 g/20 g、0.8 g/20 g，辣木叶超微粉和辣木叶醇提物的成人日剂量分别在10 g/50 kg、20 g/50 kg以下为安全剂量。 结论 辣木叶为较安全的药食两用植物，其药理作用值得进一步研究。Abstract: Objective To test the acute toxicity and determine the safe dose range of Moringa oleifera leaves and seeds. Methods Acute toxicity tests were performed based on the documented experimental designs in Research Methods of Pharmacology of Chinese Traditional Medicine. Results The maximum tolerated dose of the superfine powder and alcoholic-aqueous extract of Moringa oleifera leaves were 0.4 g/20 g and 0.8 g/20 g for mice. The safe dose for human is under or equal to 10 g/50 kg and 20 g/50 kg. Conclusion Moringa oleifera leaves were safe for medical and food use. The further research and development is warranted for this plant.
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Key words:
- Moringa oleifera /
- superfine powder process /
- acute toxicity testing
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