Observation on the clinical curative effect of edaravone combined with ginkgo diterpene lactone on acute cerebral infarction
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摘要: 目的 研究依达拉奉联合银杏二萜内酯葡胺注射液治疗急性脑梗死（ACI）的临床疗效，探讨治疗ACI更为有效的治疗方案。 方法 收集2014年1月至2015年1月于解放军463医院神经内科住院治疗的ACI患者100例，根据随机数字表法将患者分为观察组和对照组，每组各50例，观察组在常规治疗基础上加用依达拉奉和银杏二萜内酯葡胺注射液，对照组在常规治疗基础上加用银杏二萜内酯葡胺注射液。两组均连续治疗14 d，于治疗前、后采用神经功能评分比较，观察两组患者的临床疗效、不良反应和治疗满意度，并进行统计分析。 结果 治疗前两组的神经功能缺损（NIHSS）评分无显著差异（P>0.05）。治疗后观察组的NIHSS评分明显优于对照组（P<0.05）。观察组总有效率为90%，对照组为66%，差异有统计学意义（P<0.05）。两组发生的主要不良反应有皮疹、恶心、头晕，且不良反应发生率无明显差异（P>0.05）。观察组患者的治疗满意度为94%，对照组为84%，差异有统计学意义（P<0.05）。 结论 在ACI常规治疗基础上，加用依达拉奉和银杏二萜内酯葡胺注射液，能够显著改善ACI患者的神经功能，提高治疗满意度，值得在临床推广使用。Abstract: Objective To analyze the effect of edaravone combined with ginkgo diterpene lactone in treatment of acute cerebral infarction (ACI) and discuss the better clinical treatment to ACI. Methods 100 cases of ACI and who accepted treatments in our hospital were selected as the research objects in January 2014 to January 2015.50 patients as observation group were given the treatment of edaravone and ginkgo diterpene lactone at the same time,while other 50 patients as control group were merely given the treatment of ginkgo diterpene lactone.At the same time,both groups were given treatment of conventional therapy.The total neurological function,effective rate,adverse reactions,and the treatment satisfaction of both groups before and after the treatment were observed. Results There were no significant different of NIHSS score of two groups before treatment (P>0.05).After treatment,NIHSS score of the observation group was significantly lower than the control group (P<0.05).The total effective rate of observation group was 90%,which was significantly higher than the control group (66%,P<0.05).The main adverse reactions were rash,nausea,dizziness of two groups,and there were no significant different of adverse reactions rate of two groups through the treatment (P>0.05).The treatment of patients with satisfaction rate of observation group was 94%,which was significantly higher than control group (84%,P<0.05). Conclusion Edaravone combined with ginkgo diterpene lactone had a good effect on improving nerve function of ACI patients,which could improve the treatment of patients with satisfaction,high security,and could be recommended in clinical.
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[1] 张忠敏,郭艳芹,韩璎,等. 急性脑梗死侧支循环建立的神经影像学评估[J].医学研究生学报,2015,28(1):85-88. [2] 张江,麻春玲,王大力. 急性脑梗死TOAST分型、MRI分型与短期预后的关系[J]. 实用医学杂志,2015,31(1):72-75. [3] 江显萍,王启春,吴大鸿. 依达拉奉对急性缺血性脑血管病的疗效研究及机制探讨[J]. 重庆医学,2015,44(3):334-336. [4] 高聚,姜华,肖展翅,等. 银杏二萜内酯葡胺注射液治疗急性脑梗死的临床疗效观察[J]. 实用心脑肺血管病杂志,2015,23(4):133-134. [5] 张金武. 氯吡格雷联合阿司匹林在急性脑梗死治疗中的疗效评定[J]. 中国实用神经疾病杂志,2016,19(18):27-29. [6] Zhang X,Wu J,Zhang B. Xuesaitong injection as one adjuvant treatment of acute cerebral infarction:a systematic review and meta-analysis[J]. BMC Complem Altern Med,2015,15(1):560-568. [7] 刘利强,罗玉敏,吉训明. 低温治疗急性脑梗死的临床研究进展[J]. 中国脑血管病杂志,2015,12(6):325-329. [8] 美容,李世博,余碧晖,等. 依达拉奉对急性脑梗死患者神经功能及血清超敏C反应蛋白水平的影响[J]. 广东医学,2016,37(z1):214-215. [9] 李平,汪波. 依达拉奉联合溶栓治疗急性脑梗死的疗效及对氧自由基清除效果的影响[J]. 中国现代医学杂志,2015,25(28):49-52. [10] Zhou E L, Wang R J, Li M, et al. Effects of ginkgo diterpene lactones meglumine injection's activated carbon adsorption technology on officinal components[J]. Zhongguo ZhongYao ZaZhi, 2015, 40(20):3993-3997. [11] Rui TQ,Zhang L,Qiao HZ,et al. Preparation and physicochemical and pharmacokinetic characterization of Ginkgo Lactone nanosuspensions for antiplatelet aggregation[J]. J Pharm Sci,2016,105(1):242-249. [12] 曹磊,兰新新,王林晓,等. 银杏内酯注射液对大鼠急性期脑缺血再灌注损伤的保护作用[J]. 中国临床药理学与治疗学,2015,20(7):721-726. [13] 肖展翅,倪小红,李钢,等. 银杏二萜内酯葡胺注射液对脑梗死恢复期患者血液流变学的影响[J]. 中西医结合心脑血管病杂志,2015,13(16):1828-1830. -
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