酮基布洛芬贴片的制备及体外渗透性研究
Preparation and in vitro evaluation of ketoprofen gel for transdermal drug delivery
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摘要: 目的 制备酮基布洛芬凝胶贴片,并考察体外经皮渗透性。方法 以聚乙烯醇(PVA)和甘油为载体,以尿素为促进剂。结果 药物经皮渗透符合零级动力学过程,贴片中尿素含量超过10%时,有显着的透皮促进作用。结论 贴片制剂稳定,符合临床用药要求。Abstract: OBJECTIVE To study the prepartion of ketoprofen gel and its in vitro release. METHODS PVA and glycerin was used as carriers. RESULTS KFP was delivered at zero order.The higher the drug content,the faster the delivery speed.5% urea had no effect on KFP transdermal delivery.At a content of more than 10%,urea could significantly accelerate KFP transdermal delivery. CONCLUSION Gel was stable and accorded the clinical demands.
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