摘要:
目的 测定肺部感染患者静脉注射替硝唑的药物动力学。方法 采用反相高效液相色谱法测定血清中替硝唑的浓度,以甲硝唑为内标,水-乙腈-醋酸(80:20:01)为流动相,在1～50mg/L范围内线性关系良好,最低检测限0.1mg/L.7名住院肺部感染患者静脉滴注替硝唑葡萄糖注射液400mg,90min内滴完。于滴注前和滴注后取患者对侧上肢静脉血2ml测定。结果 药-时曲线符合二室开放模型,有关药动学参数分别为T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0～∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L.结论 肺部感染患者静注替硝唑的药物动力学个体差异较大。
Abstract:
OBJECTIVE To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS The concentration of tinidazole in patients'serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80:20:0 1) were used.There was a good liner relation within the range of 1～50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS The results suggested the pharmacokinetics of administrated tinidazole could be described by a linear two-compartment model.The pharmacokinetic parameters were T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0～∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L. CONCLUSIONS There was marker difference for pharmacokinetics of tinidazole among the 7 patients.
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