遍地金提取物对大鼠脑纹状体突触体[3H]-多巴胺重摄取抑制试验
Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain
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摘要: 目的 评价遍地金提取物对大鼠脑纹状体突触体[3H]-多巴胺重摄取的抑制作用。方法 通过大鼠脑纹状体突触体[3H]-多巴胺重摄取抑制实验,测定其重摄取量cmp及抑制百分率,以评价待试物对多巴胺重摄取的抑制活性。结果 遍地金组平均抑制百分率为65%,IC50=113.25mg·ml-1;St.John's Wort组平均抑制百分率为61%,IC50=28.29mg·ml-1。结论 遍地金提取物与在欧美上市的药物 St.john's Wort均抑制大鼠脑纹状体突触体[3H]-多巴胺重摄取,二者差异无统计学意义。Abstract: OBJECTIVE To study effect of hypericum wightianum extracts on synapse reuptake of dopamine in rat brain striatum. METHODS The inhibition experiment of reuptaking [3H]-dopamine on brain striatum synapse of rat has been adopted. The activity was evaluated by assaying quantity of reuptaking(cmp) and the inhibition percentage. RESULTS The average inhibition percentage and IC50 of Hypericum Wightianum extract group,are respectively 65% and 113.25 mg/ml and for St. Johns 61% and 28.29mg/ml-1 and for Wort group are. CONCLUSION Hypericum Wightianum extract group and antidepressant preparation St. John's Wort group both showed inhibition activity on brain striatum synapse reuptaking dopamine and have no statistics significance between the two groups.
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Key words:
- Hypericum Wightianum /
- dopamine /
- reuptake /
- inhibition percentage
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