回顾性分析357例次小儿抗癫痫药物血药浓度

蔡少华; 龙冬兰; 蔡韬艺

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

回顾性分析357例次小儿抗癫痫药物血药浓度

蔡少华, 龙冬兰, 蔡韬艺

文章导航 > 药学实践与服务 > 2005 > (4): @-@

蔡少华, 龙冬兰, 蔡韬艺. 回顾性分析357例次小儿抗癫痫药物血药浓度[J]. 药学实践与服务, 2005, (4): @-@.

引用本文:

蔡少华, 龙冬兰, 蔡韬艺. 回顾性分析357例次小儿抗癫痫药物血药浓度[J]. 药学实践与服务, 2005, (4): @-@.

CAI Shao-hua, LONG Dong-Ian, CAI Tao-yi. Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-@.

Citation:

CAI Shao-hua, LONG Dong-Ian, CAI Tao-yi. Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-@.

回顾性分析357例次小儿抗癫痫药物血药浓度

中国人民解放军第175医院小儿科, 福建, 漳州, 363000

Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases

Department of Pediatrics, No. 175 Hospital of PLA, Zhangzhou 363000, China

摘要: 目的回顾性分析4种常用抗癫痫药在儿童癫痫治疗中的血药浓度监测情况,以利指导合理用药.方法采用HPLC法测定丙戊酸钠、卡马西平、苯巴比妥和苯妥英钠4种常用抗癫痫药物的血药浓度.结果血药浓度在治疗窗内占47.1%,高于治疗窗占7.0%,低于治疗窗占45.9%.常规服药的患者有49.8%血药浓度在治疗窗内,联合用药致血药浓度偏离治疗窗达76.2%.结论儿童使用抗癫痫药物监测血药浓度是指导临床用药的重要依据,特别是联合用药尤其应密切监测.
- 抗癫痫药 /
- 血药浓度 /
- 儿童
Abstract: Objective The results of serum concentration monitoring of 4 antiepileptic drugs with 357 measurements in 164 epilepsy children were evaluated in order to guide clinical rational administration of these antiepileptic drugs.Methods The serum concentration of antiepileptic drugs sodium valproate (VPA), carbamazepine (CBZ),sodium phenytoin (PHT) and phenobarbital (PB) were monitored by HPLC.Results The rate of serum concentrations which were in theraputic window is 47.1%,and which were lower and higher Than theraputic window are 45.9% and 7.0% respectively.The serum concentrations in normal range are founded in only 49.8% of all patients by routine administration, and deviate from normal range by 76.2% in combination with other drugs.Conclusion Serum concentration monitor is an important basis for the treatment of children's epilepsies with antiepileptic drugs, especially in combination with other drugs.
- antiepileptic drug /
- serum concentration /
- children

[1]	晁亮, 王辉, 沈淑琦, 游飘雪, 冀凯宏, 洪战英. 基于UHPLC-Q/TOF-MS代谢组学策略的葛根-知母药对防治阿尔茨海默病的药效与作用机制研究 . 药学实践与服务, 2024, 42(): 1-11. doi: 10.12206/j.issn.2097-2024.202409035
[2]	张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英. 二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
[3]	崔亚玲, 吴琼, 马良煜, 胡北, 姚东, 许子华. 肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯皮肤药动学研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404006
[4]	陈炳辰, 佟达丰, 万苗, 闫飞虎, 姚建忠. UPLC-MS/MS法测定小鼠血浆中紫杉醇脂肪酸酯前药及其药代动力学研究 . 药学实践与服务, 2024, 42(8): 341-345. doi: 10.12206/j.issn.2097-2024.202404082
[5]	陈春娟, 郑志新, 李骊. 平喘方联合孟鲁司特钠治疗儿童支气管哮喘的临床疗效观察 . 药学实践与服务, 2024, 42(12): 524-527, 532. doi: 10.12206/j.issn.2097-2024.202405035
[6]	桂明珠, 李静, 李志玲. 儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020

点击查看大图

计量

文章访问数: 2016
HTML全文浏览量: 201
PDF下载量: 397
被引次数: 0

回顾性分析357例次小儿抗癫痫药物血药浓度

中国人民解放军第175医院小儿科, 福建, 漳州, 363000

收稿日期: 2005-06-22

关键词:

抗癫痫药 /

血药浓度 /

儿童

摘要: 目的回顾性分析4种常用抗癫痫药在儿童癫痫治疗中的血药浓度监测情况,以利指导合理用药.方法采用HPLC法测定丙戊酸钠、卡马西平、苯巴比妥和苯妥英钠4种常用抗癫痫药物的血药浓度.结果血药浓度在治疗窗内占47.1%,高于治疗窗占7.0%,低于治疗窗占45.9%.常规服药的患者有49.8%血药浓度在治疗窗内,联合用药致血药浓度偏离治疗窗达76.2%.结论儿童使用抗癫痫药物监测血药浓度是指导临床用药的重要依据,特别是联合用药尤其应密切监测.