高效液相色谱法测定阿立哌唑片剂的含量
Determination of content in aripirazole tablets by HPLC
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摘要: 目的 采用高效液相法测定阿立哌唑片中阿立哌唑的含量.方法 用Beckman C18柱,以磷酸水溶液(0.1 mL磷酸,加水500mL,加三乙胺调节pH至3.0,摇匀)-乙腈(46:54)为流动相,用紫外检测器于254nm波长处检测.结果 线性范围为2.088μg/mL-66.816μg/mL(r=0.999 99).平均回收率为99.39%.结论 本法具有操作简便,分析快速准确、干扰小等优点.Abstract: Objective To established a HPLC method for the determination of alipaizuo in its tablets. Method Alipaizuo can be separated on column with a mixture of 0.02% phosphoric acid(pH=3.0, adjusted with triethylamine) and acetonitrile (46:54) as mobile phase and detected at 254 nm. Result The linear range was from 2.088μg/mL to 66. 816μg/mL (r=0.99999) for alipaizuo. The average recovery was 99.39%. Conclusion The method is simple, rapid, accurate and reliable.
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