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口服缓控释微丸的研究进展

陈婷,  张倩,  宋洪涛

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文章导航 > 药学实践与服务  > 2011 >  29(3): 169-172,192
陈婷, 张倩, 宋洪涛. 口服缓控释微丸的研究进展[J]. 药学实践与服务, 2011, 29(3): 169-172,192.
引用本文: 陈婷, 张倩, 宋洪涛. 口服缓控释微丸的研究进展[J]. 药学实践与服务, 2011, 29(3): 169-172,192.
shu
CHEN Ting, ZHANG Qian, SONG Hong-tao. Progress of oral sustained-release and controlled-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 169-172,192.
Citation: CHEN Ting, ZHANG Qian, SONG Hong-tao. Progress of oral sustained-release and controlled-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 169-172,192.
shu

口服缓控释微丸的研究进展

  • 1.

    南京军区福州总医院药学科,福建 福州 350025;福建医科大学福总临床医学院药学科,福建 福州 350025;福建医科大学药学院,福建 福州 350004

  • 2.

    福建医科大学药学院,福建 福州 350004

  • 3.

    南京军区福州总医院药学科,福建 福州 350025;福建医科大学福总临床医学院药学科,福建 福州 350025

Progress of oral sustained-release and controlled-release pellets

  • 1.

    Department of Pharmacy,Fuzhou General Hospitol of PLA,Fuzhou 350025,China;Department of Pharmacy,School of clinical medicine of Fuzhou General Hospital,Fujian Medical University,Fuzhou 350025,China;School of Pharmacy,Fujian Medical University,Fuzhou 350004,China

  • 2.

    School of Pharmacy,Fujian Medical University,Fuzhou 350004,China

  • 3.

    Department of Pharmacy,Fuzhou General Hospitol of PLA,Fuzhou 350025,China;Department of Pharmacy,School of clinical medicine of Fuzhou General Hospital,Fujian Medical University,Fuzhou 350025,China

  • 摘要: 目的 综述近年来国内外缓控释微丸的研究进展,并展望微丸制剂的发展前景。 方法 查阅相关文献,并将其分析、归纳。 结果 阐明了不同种类缓控释微丸的特点、所选用的辅料、制备工艺及微丸压片技术。 结论 微丸作为一种多单元释药系统,具有较多优点,随着现代制备工艺的逐渐成熟及辅料的发展,微丸成为目前缓控释制剂发展的重要方向。
    Abstract: Objective To summarize the recent advances in oral sustained/controlled release pellets in international and domestic and prospect its developing future. Methods A great quantity of references were comprehensively reviewed. Results Various kinds of information of oral sustained/controlled release pellets including the characteristic,excipients,preparation methods and squash technique were summarized. Conclusions Pellets as multiple-unit drug delivery system have many advantages.With preparation techniques and excipient materials were gradually developed,pellets would play an important part in the development of sustained/controlled release drug delivery system.
  • [1] 马 萍,孙淑英,辛艳茹,等.硝苯地平海藻酸钙凝胶缓释微丸处方及工艺的优化[J].沈阳药科大学学报,2003,20(6):406.
    [2] 郑建津,沈慧风.卡波普在口服缓释制剂中的应用概况[J].中国药学杂志,2002,37(2):84.
    [3] Krause J,Thommes M,Breitkreutz J.Immediate release pellets with lipid binders obtained by solvent-free cold extrusion[J].Eur J Pharm Biopharm,2009,71:138.
    [4] Cheboyina S,Wyandt CM.Wax-based sustained release matrix pellets prepared by a novel freeze pelletization technique I. Formulation and process variables affecting pellet characteristics[J].Int J Pharm,2008,359(1-2):158.
    [5] Cheboyina S,Wyandt CM.Wax-based sustained release matrix pellets prepared by a novel freeze pelletization technique II. In vitro drug release studies and release mechanisms[J].Int J Pharm, 2008,359(1-2):167.
    [6] Young CR, Koleng JJ,McGinity JW.Production of spherical pellets by a hot-melt extrusion and spheronization process[J].Int J Pharm,2002,242(1-2):87.
    [7] Young CR,Dietzsch C,McGinity JW.Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process[J].Pharm Dev Technol,2005,10(1):133. [8] 刘 扬,张 玮,袁 臻,等.去甲斑蝥素骨架型缓释微丸的工艺优化[J].中国医院药学杂志,2008,28(15):1243. [9] 陈大为,张彦青,邹艳霜,等.灯盏花素缓释微丸制备工艺与处方优化的研究[J].中草药,2003,34(11):990.[10] 蔡翠芳,毕殿洲,毛世瑞.挤出滚圆法制备氢溴酸右美沙芬骨架缓释微丸[J].沈阳药科大学学报,2003,20(5):313.[11] 关世侠,杨 民,李海刚,等.非诺贝特缓释微丸的制备及释放度研究[J].中国医院药学杂志,2008,28(9):712.[12] Kramar A,Turk S,Vrecer F.Statistical optimisation of diclofenac sustained release pellets coated with polymethacrylic films[J].Int J Pharm,2003,256(1-2):43.[13] Siepmann F,Hoffmann A,Leclercq B,et al.How to adjust desired drug release patterns from ethylcellulose-coated dosage forms[J].J Controlled Release,2007,119:182.[14] Muschert S,Siepmann F,Leclercq B,et al.Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets[J].Eur J Pharm Biopharm,2009,72:130.[15] Serratoni M,Newton M,Booth S,et al.Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system[J].Eur J Pharm Biopharm,2007,65:94.[16] Sriamornsak P,Kennedy RA.Effect of drug solubility on release behavior of calcium polysaccharide gel-coated pellets[J].Eur J Pharm Sci,2007,32(3):231. [17] Podczeck F, Knight PE, Newton JM.The evaluation of modified microcrystalline cellulose for the preparation of pellets with high drug loading by extrusion/spheronization[J].Int J Pharm,2008,350:145. [18] Roblegg E,Ulbing S,Zeissmann S,et al.Development of lipophilic calcium stearate pellets using ibuprofen as model drug[J].Eur J Pharm Biopharm,2010,75(1):56.[19] Dukic'-Ott A,Thommes M,Remon JP,et al.Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: A critical review[J].Eur J Pharm Biopharm,2009,71:38.[20] Sousa J,Sousa A,Moura J,et al.The influence of core materials and film coating on the drug release from coated pellets[J].Int J Pharm,2002,233(1/2):111.[21] Sriamornsak P,Burton MA,Kennedy RA.Development of polysaccharide gel coated pellets for oral administration 1. Physico-mechanical properties[J].Int J Pharm,2006,326(1-2):80. [22] Abdul S,Chandewar A,Jaiswal S.A flexible technology for modified-release drugs: Multiple-unit pellet system (MUPS)[J].J Controlled Release,2010,147(1):2.
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出版历程
  • 收稿日期:  2010-09-15
  • 修回日期:  2010-12-21

口服缓控释微丸的研究进展

  • 1. 南京军区福州总医院药学科,福建 福州 350025;福建医科大学福总临床医学院药学科,福建 福州 350025;福建医科大学药学院,福建 福州 350004
  • 2. 福建医科大学药学院,福建 福州 350004
  • 3. 南京军区福州总医院药学科,福建 福州 350025;福建医科大学福总临床医学院药学科,福建 福州 350025
  • 收稿日期: 2010-09-15
  • 修回日期: 2010-12-21

摘要: 目的 综述近年来国内外缓控释微丸的研究进展,并展望微丸制剂的发展前景。 方法 查阅相关文献,并将其分析、归纳。 结果 阐明了不同种类缓控释微丸的特点、所选用的辅料、制备工艺及微丸压片技术。 结论 微丸作为一种多单元释药系统,具有较多优点,随着现代制备工艺的逐渐成熟及辅料的发展,微丸成为目前缓控释制剂发展的重要方向。

English Abstract

陈婷, 张倩, 宋洪涛. 口服缓控释微丸的研究进展[J]. 药学实践与服务, 2011, 29(3): 169-172,192.
引用本文: 陈婷, 张倩, 宋洪涛. 口服缓控释微丸的研究进展[J]. 药学实践与服务, 2011, 29(3): 169-172,192.
shu
CHEN Ting, ZHANG Qian, SONG Hong-tao. Progress of oral sustained-release and controlled-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 169-172,192.
Citation: CHEN Ting, ZHANG Qian, SONG Hong-tao. Progress of oral sustained-release and controlled-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 169-172,192.
shu

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