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核辐射事故伤药物防治研究进展

刘玉明 张术 储智勇

刘玉明, 张术, 储智勇. 核辐射事故伤药物防治研究进展[J]. 药学实践与服务, 2011, 29(5): 321-323,346.
引用本文: 刘玉明, 张术, 储智勇. 核辐射事故伤药物防治研究进展[J]. 药学实践与服务, 2011, 29(5): 321-323,346.
LIU Yu-ming, ZHANG Shu, CHU Zhi-yong. Advances on the medication of nuclear Radiation Accidents[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 321-323,346.
Citation: LIU Yu-ming, ZHANG Shu, CHU Zhi-yong. Advances on the medication of nuclear Radiation Accidents[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 321-323,346.

核辐射事故伤药物防治研究进展

Advances on the medication of nuclear Radiation Accidents

  • 摘要: 随着世界各国核军备竞争的加剧,随着世界核安全形势的紧张以及核技术研究手段的不断兴起,核辐射对人类造成了极大的恐慌和伤害。如何加强核事故和核辐射损伤的应急防护和医学救治,这已经引起人们的高度重视和关注。本文针对核辐射的临床表现,从综合治疗、细胞因子、氨巯基化合物、中草药四方面,综述了目前在核事故及核辐射中药物预防与救治的研究进展,并对今后如何深入对核辐射防治药物进行开发利用进行了展望。
  • [1] Fliedner TM,Graessle D,Meineke V,et al.Pathophysiological principles underlying the blood cell concentration responses used to assess the severity of efect after accidental whole body radiation exposure:an essential basis for an evidence.based clinical triage[J].Exp Hematol,2007,35(4 Suppl 1):8.
    [2] Heimers A,Brede HJ,Giesen U,et al.Chromosome aberration analysis and the influence of mitotic delay after simulated partial-body exposure with hi gh doses uf sparsely and densely ionizing radiation[J].Radiat Environ Biophys,2006,45(1):45.
    [3] Hande MP,Azizuva TV,Burak LE,et al.Complex chromosome aberrations persist in individuals man y years after occupational exposure to densely ionizing radiation:an mF1SH study[J].Genes Chromosomes Cancer,2005,44(1):1.
    [4] Wang Y,Schulte BA,Zhou D.Hematopoietic stem cell senescence and long-term bone marrow injury[J].Cell Cycle,2006,5(1):35.
    [5] Wang Y,Schulte BA,LaRue AC,et al.Total body irradiation selectively induces murine hematopoietic stem cell senescence[J].Blood, 2006.107(1):358.
    [6] Liu YJ,Lu SH,Xu B,et al. Hemangiopoietin,a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages[J].Blood,2004,103(12):4449.
    [7] Herodin F,Drouet M.Cytokine-based treatment of accidentally irradiated victims and new approaches[J].Exp Hematol,2005,33(10),1071.
    [8] Hosseinimehr SJ, Zakaryaee V, Frouhgizaden M. Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells[J]. Mol Cell Biochem,2006,287:193.
    [9] Drouet M,Mourcin F,Grenier N,et al.Single administration of stemcell factor.FL -3 ligand.megakaryocyte growth and developmentfactor.and interleukin-3 in combination soon after irradiationprevents nonhuman primates from myelosuppression:long-term follow-up of hematopoiesis[J].Blood,2004,103(3):878.
    [10] Demirel C, Kilciksiz S, Ay OI,et al. Effect of N-acetylcysteine on radiation-induced genotoxicity and cytotoxicity in rat bone marrow[J]. Journal-of-radiation-research,2009,50(1): 43.
    [11] Demirel C, Kilciksiz S,Evirgen S,et al. The preventive effect of N-acetylcysteine on radiation-induced dermatitis in a rat model[J]. J-BUON. 2010 ,15(3): 577.
    [12] Murley J S, Kataoka Y,Baker KL,et al. Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha[J]. Radiation-research,2007 ,167(4): 465.
    [13] You WC, Lin WC, Huang JT ,et al.Indigowood root extract protects hematopoietic cells reduces tissue damage and modulates inflammatory cytokines after total-body irradiation: does Indirubin play a role in radioprotection[J]. Phytomedicine,2009 ,16(12): 1105.
    [14] Liu WC, Wang SC,Tsai ML, et al.Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine[J]. Radiat-Res, 2006 , 166(6): 900.
    [15] 陆兴熠 ,刘剑英,钟进义. 葡多酚对核辐射接触人员氧化损伤防护作用[J]. 中国公共卫生,2008,24(9):1072.
    [16] Goel HC, Bala M, Prasad J,et al,Radioprotection by Rhodiola imbricate in mice against whole-body lethal irradiation[J]. J Med Food. 2006 , 9(2): 154.
    [17] 梁 莉,王 婷,乔 华,等.南沙参多糖的药理作用研究进展[J]. 西北药学杂志,2008,(23) 5:334.
    [18] Li Z,Wenyi Z,Liang'an Z. General situation of radiation accidents in China[J]. Radiat Prot Dosimety,2007,124(2):177.
    [19] Weisdorf D,ChaoN,Waelenko JK,et al.Acute radiation injury:contingency planning for triage,supportive care,and transplantation[J]. Biol Blood Marrow Transplant, 2006,12(6):672.
    [20] Rencova J, Vlkova A, Vesela G. Improved chelation therapy of intramuscularly deposited horium by CaDTPA in the rat [J]. Radiat Prot Dosim, 2003, 105 : 513.
    [21] Martinez AB, Mandalunis PM, Bozal CB, et al. Renal function in mice poisoned with oral uranium and treated with ethane-1-hydroxy-1, 1-bisphosphonate ( EHBP) [J]. Health Phys, 2003, 85(3):343.
    [22] Benkovic V, Knezevic AH, Dikic D, et al. Radioprotective effects of quercetin and ethanolic extract of propolis in gamma-irradiated mice[J]. Arh Hig Rada Toksikol, 2009 , 60(2): 129.
    [23] Srinivasan M, Devipriya N, Kalpana KB, et al. Lycopene: An antioxidant and radioprotector against gamma-radiation-induced cellular damages in cultured human lymphocytes[J]. Toxicology, 2009, 262(1): 43.
    [24] Goel A, Aggarwal BB. Curcumin the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs[J]. Nutr Cancer, 2010, 62(7): 919.
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  • 收稿日期:  2010-11-15
  • 修回日期:  2011-04-19

核辐射事故伤药物防治研究进展

摘要: 随着世界各国核军备竞争的加剧,随着世界核安全形势的紧张以及核技术研究手段的不断兴起,核辐射对人类造成了极大的恐慌和伤害。如何加强核事故和核辐射损伤的应急防护和医学救治,这已经引起人们的高度重视和关注。本文针对核辐射的临床表现,从综合治疗、细胞因子、氨巯基化合物、中草药四方面,综述了目前在核事故及核辐射中药物预防与救治的研究进展,并对今后如何深入对核辐射防治药物进行开发利用进行了展望。

English Abstract

刘玉明, 张术, 储智勇. 核辐射事故伤药物防治研究进展[J]. 药学实践与服务, 2011, 29(5): 321-323,346.
引用本文: 刘玉明, 张术, 储智勇. 核辐射事故伤药物防治研究进展[J]. 药学实践与服务, 2011, 29(5): 321-323,346.
LIU Yu-ming, ZHANG Shu, CHU Zhi-yong. Advances on the medication of nuclear Radiation Accidents[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 321-323,346.
Citation: LIU Yu-ming, ZHANG Shu, CHU Zhi-yong. Advances on the medication of nuclear Radiation Accidents[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 321-323,346.
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