-
脂质体是包封药物纳米载体的理想选择[1],它可以提高被包载物质溶解度,增强物质的稳定性,减少外周不良反应发生,且自身无毒。在肿瘤疾病治疗中,依赖高渗透长滞留(EPR)效应的假设,基于病变区域的组织结构、生理功能和正常组织间的差异,脂质体可使药物输送至肿瘤组织富集,更好地发挥治疗作用[2]。但是,基于EPR效应的纳米制剂在实体瘤内转运的靶向效率仍面临很多质疑[3],所有纳米颗粒(包括脂质体在内)仅有0.7%(中位数)的注射剂量被递送至实体瘤,面临脱颗粒困难、药物释放缓慢等问题[4]。因此在脂质体载体的研究中,针对内源性刺激因素pH[5]、氧化还原反应[6]和酶等[7],外源性刺激因素温度变化[8]、磁场[9]、光等[10],研究者开发出基于刺激响应以及具有主动运输功能的靶向脂质体,以期在目标部位高效、可控地释放运载药物,提高脂质体的靶向性并增强细胞毒性[11]。
Application progress of ROS-responsive liposomes in anti-tumor research
-
摘要: 活性氧自由基响应型脂质体是基于肿瘤微环境中活性氧自由基(ROS)高水平表达的特点而制备,可使包载药物在肿瘤部位精准释放。在外加光敏剂后,能进一步增强脂质体中药物的可控性。Abstract: Reactive oxygen species(ROS) responsive liposomes are prepared based on the high level of ROS expression in the tumor microenvironment, enabling precise drug delivery to the tumor site. With the addition of photosensitizer, the controllability of drugs in liposomes can be further enhanced.
-
Key words:
- reactive oxygen species /
- liposomes /
- tumor /
- photosensitizer
-
[1] PATTNI B S, CHUPIN V V, TORCHILIN V P. New developments in liposomal drug delivery[J]. Chem Rev,2015,115(19):10938-10966. doi: 10.1021/acs.chemrev.5b00046 [2] PALIWAL S R, PALIWAL R, AGRAWAL G P, et al. Hyaluronic acid modified pH-sensitive liposomes for targeted intracellular delivery of doxorubicin[J]. J Liposome Res,2016,26(4):276-287. doi: 10.3109/08982104.2015.1117489 [3] WILHELM S, TAVARES A J, DAI Q, et al. Analysis of nanoparticle delivery to tumours[J]. Nat Rev Mater,2016,1(5):16014. doi: 10.1038/natrevmats.2016.14 [4] PRABHAKAR U, MAEDA H, JAIN R K, et al. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology[J]. Cancer Res,2013,73(8):2412-2417. doi: 10.1158/0008-5472.CAN-12-4561 [5] LI M, SHI K, TANG X, et al. pH-sensitive folic acid and dNP2 peptide dual-modified liposome for enhanced targeted chemotherapy of glioma[J]. Eur J Pharm Sci,2018,124:240-248. doi: 10.1016/j.ejps.2018.07.055 [6] XIA X L, YANG X Y, HUANG P, et al. ROS-responsive nanoparticles formed from RGD-epothilone B conjugate for targeted cancer therapy[J]. ACS Appl Mater Interfaces,2020,12(16):18301-18308. doi: 10.1021/acsami.0c00650 [7] DE LA RICA R, AILI D, STEVENS M M. Enzyme-responsive nanoparticles for drug release and diagnostics[J]. Adv Drug Deliv Rev,2012,64(11):967-978. doi: 10.1016/j.addr.2012.01.002 [8] YU F, WU H, TANG Y, et al. Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system[J]. Int J Pharm,2018,536(1):11-20. doi: 10.1016/j.ijpharm.2017.11.025 [9] PODARU G, OGDEN S, BAXTER A, et al. Pulsed magnetic field induced fast drug release from magneto liposomes via ultrasound generation[J]. J Phys Chem B,2014,118(40):11715-11722. doi: 10.1021/jp5022278 [10] LUO D, LI N, CARTER K A, et al. Rapid light-triggered drug release in liposomes containing small amounts of unsaturated and porphyrin-phospholipids[J]. Small,2016,12(22):3039-3047. doi: 10.1002/smll.201503966 [11] ELOY J O, PETRILLI R, TREVIZAN L N F, et al. Immunoliposomes: a review on functionalization strategies and targets for drug delivery[J]. Colloids Surf B Biointerfaces,2017,159:454-467. doi: 10.1016/j.colsurfb.2017.07.085 [12] BRIEGER K, SCHIAVONE S, MILLER F J, et al. Reactive oxygen species: from health to disease[J]. Swiss Med Wkly,2012,142:w13659. [13] INOUE M, SATO E F, NISHIKAWA M, et al. Mitochondrial generation of reactive oxygen species and its role in aerobic life[J]. Curr Med Chem,2003,10(23):2495-2505. doi: 10.2174/0929867033456477 [14] LIOU G Y, STORZ P. Reactive oxygen species in cancer[J]. Free Radic Res,2010,44(5):479-496. doi: 10.3109/10715761003667554 [15] MANDA G, ISVORANU G, COMANESCU M V, et al. The redox biology network in cancer pathophysiology and therapeutics[J]. Redox Biol,2015,5:347-357. doi: 10.1016/j.redox.2015.06.014 [16] PANIERI E, SANTORO M M. ROS homeostasis and metabolism: a dangerous liason in cancer cells[J]. Cell Death Dis,2016,7(6):e2253. doi: 10.1038/cddis.2016.105 [17] SZATROWSKI T P, NATHAN C F. Production of large amounts of hydrogen peroxide by human tumor cells[J]. Cancer Res,1991,51(3):794-798. [18] CHIANG Y T, YEN Y W, LO C L. Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer[J]. Biomaterials,2015,61:150-161. doi: 10.1016/j.biomaterials.2015.05.007 [19] DU Y, HE W, XIA Q, et al. Thioether phosphatidylcholine liposomes: a novel ROS-responsive platform for drug delivery[J]. ACS Appl Mater Interfaces,2019,11(41):37411-37420. doi: 10.1021/acsami.9b08901 [20] LOU J C, BEST M D. Reactive oxygen species-responsive liposomes via boronate-caged phosphatidylethanolamine[J]. Bioconjugate Chem,2020,31(9):2220-2230. doi: 10.1021/acs.bioconjchem.0c00397 [21] NOYHOUZER T, L’HOMME C, BEAULIEU I, et al. Ferrocene-modified phospholipid: an innovative precursor for redox-triggered drug delivery vesicles selective to cancer cells[J]. Langmuir,2016,32(17):4169-4178. doi: 10.1021/acs.langmuir.6b00511 [22] CLEGG A D, REES N V, KLYMENKO O V, et al. Marcus theory of outer-sphere heterogeneous electron transfer reactions: High precision steady-state measurements of the standard electrochemical rate constant for ferrocene derivatives in alkyl cyanide solvents[J]. J Electroanal Chem,2005,580(1):78-86. doi: 10.1016/j.jelechem.2005.03.013 [23] 卢光照, 侯 成, 钟延强, 等. 活性氧自由基响应给药系统研究进展[J]. 药学学报, 2017, 52(2):206-213. doi: 10.16438/j.0513-4870.2016-0923 [24] FUSE T, TAGAMI T, TANE M, et al. Effective light-triggered contents release from helper lipid-incorporated liposomes co-encapsulating gemcitabine and a water-soluble photosensitizer[J]. Int J Pharm,2018,540(1-2):50-56. doi: 10.1016/j.ijpharm.2018.01.040 [25] ZHAO Z H, WANG W Q, LI C X, et al. Reactive oxygen species–activatable liposomes regulating hypoxic tumor microenvironment for synergistic photo/chemodynamic therapies[J]. Adv Funct Mater,2019,29(44):1905013. doi: 10.1002/adfm.201905013 [26] CARTER K A, LUO D, RAZI A, et al. Sphingomyelin liposomes containing porphyrin-phospholipid for irinotecan chemophototherapy[J]. Theranostics,2016,6(13):2329-2336. doi: 10.7150/thno.15701
计量
- 文章访问数: 5395
- HTML全文浏览量: 2079
- PDF下载量: 108
- 被引次数: 0