Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet
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摘要: 目的 研究尼莫地平口腔崩解片在人体内的药动学, 比较其与市售尼莫地平片人体内药物动力学及相对生物利用度。 方法 将6名健康志愿者随机分成两组,交叉单剂量口服尼莫地平口腔崩解片A 和市售片B 各60 mg,采用HPLC 法测定血浆中尼莫地平的浓度。 结果 口服尼莫地平口腔崩解片A 和市售片B后,主要药代动力学参数分别为Cmax (256.23±54.64) g/ml、(102.415±36.96) g/ml;Tmax 分别为 (0.7049±0.035) h、(1Abstract: Objective To research the pharmacokinetics and relative bioavailability of Nimodipine rapid disintegeating tablet in human body, which was compared with Nimodipine market tablets. Methods 6 cases of health volunteer were divide into two groups randomly , alternately taking rapid disintegeating tablet A and market tablet B of Nimodipine 60mg single dosage orally, HPLC was used to determine the concentration of Nimodipine in blood. Results The main Pharmacokinetics parameters after single oral administration Nimodipine rapid disintegeating tablet A and Nimodipine market tablet B were (256.23±54.64) g/ml, (102.415±36.96) g/ml in Cmax; (0.7049±0.035) h, (1.3317±0.123) h in Tmax; (0.2734±0.031) h, (1.1958±0.141) h in T1/2; (622.77±98.03) g/(ml·h), (354.63±96.24) g/(ml·h) in AUC0 - t, respectively. The bioavailability of rapid disintegeating tablet was 177.27% relative to market tablet. Conclusion Nimodipine rapid disintegeating tablet was capable of releasing rapidly, and had an enhanced bioavailability as compared with market tablet.
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Key words:
- nimodipine /
- HPLC /
- pharmacokinetics /
- relative bioavailability
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