青蒿琥酯和熊果酸降血脂作用的最佳配比筛选

叶亚琳; 王玉亮; 王泽剑; 殷明; 辛海量; 张磊

doi:10.3969/j.issn.1006-0111.2014.03.008

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青蒿琥酯和熊果酸降血脂作用的最佳配比筛选

叶亚琳, 王玉亮, 王泽剑, 殷明, 辛海量, 张磊

文章导航 > 药学实践与服务 > 2014 > 32(3): 195-198

叶亚琳, 王玉亮, 王泽剑, 殷明, 辛海量, 张磊. 青蒿琥酯和熊果酸降血脂作用的最佳配比筛选[J]. 药学实践与服务, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008

引用本文:

YE Yalin, WANG Yuliang, WANG Zejian, YIN Ming, XIN Hailiang, ZHANG Lei. Screening the best ratio of artesunate and ursolic acid for lipid-lowering[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008

Citation:

YE Yalin, WANG Yuliang, WANG Zejian, YIN Ming, XIN Hailiang, ZHANG Lei. Screening the best ratio of artesunate and ursolic acid for lipid-lowering[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008

青蒿琥酯和熊果酸降血脂作用的最佳配比筛选

doi: 10.3969/j.issn.1006-0111.2014.03.008

1.
解放军421医院药剂科, 广东广州 510310
2.
上海交通大学农业与生物学院, 上海 200240;上海交通大学药学院, 上海 200240
3.
上海交通大学药学院, 上海 200240
4.
第二军医大学中医系, 上海 200433
5.
第二军医大学药学院, 上海 200433

基金项目: 上海市科委中药现代化专项(10DZ1971500).

Screening the best ratio of artesunate and ursolic acid for lipid-lowering

1.
NO.421 Hospital of PLA, Guangzhou 510310, China
2.
School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China;School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China
3.
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China
4.
School of Traditional;Chinese Medicine, Second Military Medical University, Shanghai 200433, China
5.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 目的观察青蒿琥酯和熊果酸不同剂量和配伍对大鼠脂质代谢紊乱模型的影响,寻找青蒿琥酯和熊果酸配伍应用的最佳配比。方法利用喂养高脂饲料诱导大鼠形成脂质代谢紊乱模型,通过比较各给药组大鼠的血脂水平筛选最佳配比。结果实验结果显示,青蒿琥酯(高剂量)+熊果酸(高剂量)均有显著降低TG、CHO、LDL-C作用,可明显升高HDL-C,对H/L值也有一定的升高作用。综合降脂效果优于阳性药非诺贝特,也优于单用同等剂量的青蒿琥酯或熊果酸。各受试样品对大鼠肝功能没有显著影响(P>0.05,与正常组比较)。结论青蒿琥酯和熊果酸1:1配比降脂效果最佳,建议剂量为(50+50) mg/kg。
- 青蒿琥酯 /
- 熊果酸 /
- 高血脂 /
- 大鼠 /
- 脂代谢
Abstract: Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induced by feeding high fat diet in rat.The best ratio was screened through comparing the lipid level of rats ofdifferent groups. Results The results showed that Artesunate (high dose)+Ursolicacid (high dose) significantly reduced TG, CHO and LDL-C, increased HDL-C and H/L. Lipid-lowering effect was superior the positive drug fenofibrate, but also superior to the same dose of artesunate and ursolic acid alone. No significant effect of each test sample on the rat liver function was observed(P>0.05). Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.
- artesunate /
- ursolic acid /
- hyperlipidemia /
- rat /
- lipid metabolism

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青蒿琥酯和熊果酸降血脂作用的最佳配比筛选

doi: 10.3969/j.issn.1006-0111.2014.03.008

1. 解放军421医院药剂科, 广东广州 510310

2. 上海交通大学农业与生物学院, 上海 200240;上海交通大学药学院, 上海 200240

3. 上海交通大学药学院, 上海 200240

4. 第二军医大学中医系, 上海 200433

5. 第二军医大学药学院, 上海 200433

基金项目: 上海市科委中药现代化专项(10DZ1971500).

收稿日期: 2013-05-01
修回日期: 2013-09-12

关键词:

青蒿琥酯 /

熊果酸 /

高血脂 /

大鼠 /

脂代谢

摘要: 目的观察青蒿琥酯和熊果酸不同剂量和配伍对大鼠脂质代谢紊乱模型的影响,寻找青蒿琥酯和熊果酸配伍应用的最佳配比。方法利用喂养高脂饲料诱导大鼠形成脂质代谢紊乱模型,通过比较各给药组大鼠的血脂水平筛选最佳配比。结果实验结果显示,青蒿琥酯(高剂量)+熊果酸(高剂量)均有显著降低TG、CHO、LDL-C作用,可明显升高HDL-C,对H/L值也有一定的升高作用。综合降脂效果优于阳性药非诺贝特,也优于单用同等剂量的青蒿琥酯或熊果酸。各受试样品对大鼠肝功能没有显著影响(P>0.05,与正常组比较)。结论青蒿琥酯和熊果酸1:1配比降脂效果最佳,建议剂量为(50+50) mg/kg。

English Abstract

Screening the best ratio of artesunate and ursolic acid for lipid-lowering

1. NO.421 Hospital of PLA, Guangzhou 510310, China

2. School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China;School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

3. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

4. School of Traditional;Chinese Medicine, Second Military Medical University, Shanghai 200433, China

5. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-05-01
Rev Recd Date: 2013-09-12

Keywords:

Abstract: Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induced by feeding high fat diet in rat.The best ratio was screened through comparing the lipid level of rats ofdifferent groups. Results The results showed that Artesunate (high dose)+Ursolicacid (high dose) significantly reduced TG, CHO and LDL-C, increased HDL-C and H/L. Lipid-lowering effect was superior the positive drug fenofibrate, but also superior to the same dose of artesunate and ursolic acid alone. No significant effect of each test sample on the rat liver function was observed(P>0.05). Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.

引用本文: