左卡尼汀预防紫杉醇周围神经毒性的临床观察

严建维

doi:10.3969/j.issn.1006-0111.2014.05.016

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左卡尼汀预防紫杉醇周围神经毒性的临床观察

严建维

文章导航 > 药学实践与服务 > 2014 > 32(5): 372-373

严建维. 左卡尼汀预防紫杉醇周围神经毒性的临床观察[J]. 药学实践与服务, 2014, 32(5): 372-373. doi: 10.3969/j.issn.1006-0111.2014.05.016

引用本文:

严建维. 左卡尼汀预防紫杉醇周围神经毒性的临床观察[J]. 药学实践与服务, 2014, 32(5): 372-373. doi: 10.3969/j.issn.1006-0111.2014.05.016

YAN Jianwei. Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 372-373. doi: 10.3969/j.issn.1006-0111.2014.05.016

Citation:

YAN Jianwei. Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 372-373. doi: 10.3969/j.issn.1006-0111.2014.05.016

左卡尼汀预防紫杉醇周围神经毒性的临床观察

doi: 10.3969/j.issn.1006-0111.2014.05.016

严建维

余姚市人民医院内科, 浙江余姚 315400

Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel

YAN Jianwei

Department of Medicine, Yuyao People's Hospital, Yuyao 315400, China

摘要: 目的观察左卡尼汀预防紫杉醇引起的周围神经毒性作用。方法将 64例接受紫杉醇化疗的肿瘤患者随机分为两组,预防性治疗组患者在应用紫杉醇化疗同时给予左卡尼汀治疗,对照组化疗方案与前组相同但未接受左卡尼汀预防性治疗。分别比较两组患者的周围神经毒性发生率。结果预防性治疗组周围神经毒性发生率低于对照组,差异有统计学意义(P<0.05)。结论应用紫杉醇联合化疗中预防性给予左卡尼汀,可减少化疗相关的周围神经毒性。
- 左卡尼汀 /
- 紫杉醇 /
- 神经毒性
Abstract: Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by paclitaxel. Methods 64 cancer patients treated with paclitaxel-based chemotherapy were randomly divided into two groups, the preventive treatment group and control group.The patients in the preventive treatment group were treated with paclitaxel chemotherapy and levocarnitine.The patients in the control group were treated with the same chemotherapy but without levocarnitine.The incidence rate of neurotoxicity between two groups were compared. Results The incidence rate of neurotoxicity in the preventive treatment group was lower than that of the control group(P<0.05). Conclusion Application of levocarnitine in paclitaxel-based chemotherapy could reduce the neurotoxicity caused by chemotherapy.
- levocarnitine /
- paclitaxel /
- neurotoxicity

[1]	Ghirardi O,Lo Giudice P,Pisano C,et al.Acetyl-L-carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin,without altering its antitumor properties[J].Anticancer Res,2005,25(4):2681-2687.
[2]	Gunes D, Kirkim G, Kolatan E,et al. Evaluation of the effect of acetyl L-carnitine on experimental cisplatin ototoxicity and neurotoxicity[J].Chemotherapy,2011,57(3):186-194.
[3]	孙燕.抗癌药物急性与亚急性毒性反应分度标准临床肿瘤手册[M].5版.北京:人民卫生出版社,2005:145.
[4]	Xiao WH, Zheng H, Zheng FY,et al. Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat[J].Neuroscience,2011,199:461-469.
[5]	He MD, Xu SC, Lu YH,et al.L-carnitine protects against nickel-induced neurotoxicity by maintaining mitochondrial function in neuro-2a cells[J].Toxicol Appl Pharmacol,2011,253(1):38-44.
[6]	Nagesh BG, Kumar A, Singh RL.Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function[J].Neurotox Res,2011,19(2):319-329.
[7]	Zheng H, Xiao WH, Bennett GJ. Functional deficits in peripheral nerve mitochondria in rats with paclitaxel-and oxaliplatin-evoked painfulperipheral neuropathy[J]. Exp Neurol,2011,232(2):154-161.

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左卡尼汀预防紫杉醇周围神经毒性的临床观察

doi: 10.3969/j.issn.1006-0111.2014.05.016

严建维

余姚市人民医院内科, 浙江余姚 315400

收稿日期: 2013-04-01
修回日期: 2013-07-30

关键词:

左卡尼汀 /

紫杉醇 /

神经毒性

摘要: 目的观察左卡尼汀预防紫杉醇引起的周围神经毒性作用。方法将 64例接受紫杉醇化疗的肿瘤患者随机分为两组,预防性治疗组患者在应用紫杉醇化疗同时给予左卡尼汀治疗,对照组化疗方案与前组相同但未接受左卡尼汀预防性治疗。分别比较两组患者的周围神经毒性发生率。结果预防性治疗组周围神经毒性发生率低于对照组,差异有统计学意义(P<0.05)。结论应用紫杉醇联合化疗中预防性给予左卡尼汀,可减少化疗相关的周围神经毒性。