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肿瘤靶向纳米递释系统存在问题的分析

李文清 邹豪 钟延强

李文清, 邹豪, 钟延强. 肿瘤靶向纳米递释系统存在问题的分析[J]. 药学实践与服务, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
引用本文: 李文清, 邹豪, 钟延强. 肿瘤靶向纳米递释系统存在问题的分析[J]. 药学实践与服务, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
Citation: LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003

肿瘤靶向纳米递释系统存在问题的分析

doi: 10.3969/j.issn.1006-0111.2015.02.003

Analysis of problems on tumor-targeting drug delivery system

  • 摘要: 目的 探究目前肿瘤靶向纳米递释系统存在的问题。 方法 在全面搜集查阅有关文献的基础上, 对肿瘤靶向纳米递释系统研究现状进行归纳整理。 结果 从3个方面对肿瘤靶向纳米递释系统存在的问题以及新的发展趋势提出建议与对策。 结论 要在研究中取得突破, 需要对人体生理学及肿瘤生物学进行深入研究, 并在现有的给药策略和实验方法等方面进行调整。
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    [2] 高 芸,李少一,商雪莹,等. FAT10过表达对肝癌细胞HepG2侵袭及迁移能力的影响[J].实用预防医学, 2013,20(5):517-520.
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    [17] Lu W,Wan J,She Z,et al.Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle[J].J Control Release,2007,118(1):38-53.
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    [20] Grantab R, Sivananthan S, Tannock IF. The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells[J]. Cancer Res, 2006,66(2): 1033-1039.
    [21] Netti PA, Berk DA, Swartz M A,et al. Role of etracellular matrix assembly in interstitial transport in solid tumors[J]. Cancer Res, 2000,60(9): 2497-2503.
    [22] Brown E, Mckee TD, Tomaso ED, et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation[J]. Nat Med, 2003,9(6): 796-800.
    [23] Ramanujan S, Pluen A, Mckee TD, et al. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium[J]. Biophys J, 2002,83(3): 1650-1660.
    [24] Alexandrakis G, Brown E, Tong RT, et al. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors[J]. Nat Med, 2004,10(2): 203-207.
    [25] Ernsting MJ, Murakami M, Roy A, et al. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles[J]. J Control Release, 2013,172(3): 782-794.
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出版历程
  • 收稿日期:  2014-01-14
  • 修回日期:  2014-09-23

肿瘤靶向纳米递释系统存在问题的分析

doi: 10.3969/j.issn.1006-0111.2015.02.003

摘要: 目的 探究目前肿瘤靶向纳米递释系统存在的问题。 方法 在全面搜集查阅有关文献的基础上, 对肿瘤靶向纳米递释系统研究现状进行归纳整理。 结果 从3个方面对肿瘤靶向纳米递释系统存在的问题以及新的发展趋势提出建议与对策。 结论 要在研究中取得突破, 需要对人体生理学及肿瘤生物学进行深入研究, 并在现有的给药策略和实验方法等方面进行调整。

English Abstract

李文清, 邹豪, 钟延强. 肿瘤靶向纳米递释系统存在问题的分析[J]. 药学实践与服务, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
引用本文: 李文清, 邹豪, 钟延强. 肿瘤靶向纳米递释系统存在问题的分析[J]. 药学实践与服务, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
Citation: LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
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