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中国西沙群岛沐浴海绵的化学成分研究

田园 徐彬 王景凤 林厚文 杨连娟 杨帆

田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
引用本文: 田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
Citation: TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007

中国西沙群岛沐浴海绵的化学成分研究

doi: 10.3969/j.issn.1006-0111.2017.04.007
基金项目: 北京医学奖励基金(YJHYXKYJJ-125);上海市科委科技支撑项目(15431900900)

Chemical constituents from Spongia sp., a marine sponge in Xisha Islands

  • 摘要: 目的 研究中国西沙群岛沐浴海绵Spongia sp.的化学成分。 方法 运用正相硅胶柱色谱、反相ODS柱色谱、Sephadex LH-20凝胶柱色谱以及半制备高效液相色谱等多种色谱学分离手段,对沐浴海绵Spongia sp.的石油醚萃取层进行分离纯化;通过理化性质、波谱学数据并结合文献报道鉴定化合物的结构,采用微量稀释法评价化合物的体外抗真菌活性。 结果 从海绵Spongia sp.中分离并鉴定了9个化合物,分别为smenodiol( 1 )、smenospongorine( 2 )、5-epi-smenospongorine( 3 )、dictyoceratin C( 4 )、epi-smenospongidine( 5 )、 dictyoceratin A( 6 )、stigmasta-4,6,8(14 ),22-tetraen-3-one( 7 )、3-oxo-4,6,8(14 )-triunsaturated steroid( 8 )、ergosta-4,6,8(14 ),22-tetraen-3-one( 9 )。 结论 化合物 1 ~ 9 均为首次从该属海绵中分离得到,体外抗真菌活性测试显示,化合物 2359 对3种受试菌株(白色念珠菌、须癣毛癣菌和红色毛癣菌)表现出程度不等的抑制活性,MIC值范围在12.5~25 μg/ml。
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  • 收稿日期:  2017-01-17
  • 修回日期:  2017-04-14

中国西沙群岛沐浴海绵的化学成分研究

doi: 10.3969/j.issn.1006-0111.2017.04.007
    基金项目:  北京医学奖励基金(YJHYXKYJJ-125);上海市科委科技支撑项目(15431900900)

摘要: 目的 研究中国西沙群岛沐浴海绵Spongia sp.的化学成分。 方法 运用正相硅胶柱色谱、反相ODS柱色谱、Sephadex LH-20凝胶柱色谱以及半制备高效液相色谱等多种色谱学分离手段,对沐浴海绵Spongia sp.的石油醚萃取层进行分离纯化;通过理化性质、波谱学数据并结合文献报道鉴定化合物的结构,采用微量稀释法评价化合物的体外抗真菌活性。 结果 从海绵Spongia sp.中分离并鉴定了9个化合物,分别为smenodiol( 1 )、smenospongorine( 2 )、5-epi-smenospongorine( 3 )、dictyoceratin C( 4 )、epi-smenospongidine( 5 )、 dictyoceratin A( 6 )、stigmasta-4,6,8(14 ),22-tetraen-3-one( 7 )、3-oxo-4,6,8(14 )-triunsaturated steroid( 8 )、ergosta-4,6,8(14 ),22-tetraen-3-one( 9 )。 结论 化合物 1 ~ 9 均为首次从该属海绵中分离得到,体外抗真菌活性测试显示,化合物 2359 对3种受试菌株(白色念珠菌、须癣毛癣菌和红色毛癣菌)表现出程度不等的抑制活性,MIC值范围在12.5~25 μg/ml。

English Abstract

田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
引用本文: 田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
Citation: TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
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