聚乳酸分子量对利福平聚乳酸微球性质的影响
Study on rifampicin polylactic acid microspheres:Effect of molecular weight of polylactic acid (PLA) on the properties of microspheres
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摘要: 目的 考察聚乳酸分子量对利福平聚乳酸微球性质的影响。方法 采用分散一溶媒扩散法制备利福平聚乳酸微球,测定微球的粒径分布和包封率,进行体外释药和稳定性试验。结果 在本制备方法中,聚乳酸分子量对微球粒径分布的影响作用不明显;药物包封率随聚乳酸分子量增大而增加;聚乳酸分子量减小,微球体外释药速度加快。稳定性试验表明,微球在4℃和室温(20～25℃)条件下性质稳定:37℃条件下因聚乳酸软化,微球发生粘连聚集。结论 应根据实验目的选择适宜分子量的聚乳酸,以获得所需性质的微球。Abstract: OBJECTIVE To discover the effect of molecular weight of PLA on the properties of rifampicin polylactic acid microspheres.METHODS Rifampicin polylactic acid microspheres were prepared by dispersion-solvent diffusion method.The microsphere size distribution and drug encapsulation efficiency were determined.The experiments on in vitro releasing property and stability of the microspheres were also carried out.RESULTS The relationship between molecular weight of PLA and the particle size distribution had not been seen. PLA of low molecular weight could decrease the drug encapsulation efficiency and accelerate the drug releasing rate.The experiments on stability showed that the microspheres were stable under 4℃or room temperature.Fusion and aggregation of the microspheres happened under 37℃ due to low glasstransition temperature of PLA polymer.CONCLUSION PLA microspheres of proper characteristics should be prepared from polylactic acid of certain molecular weight.
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Key words:
- polylactic acid /
- microspheres /
- molecular weight /
- rifampicin
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