摘要:
目的 :研究清知源软胶囊对大鼠血脂的调节作用以及抗氧化活性的影响。 方法 :采用50只健康 Wistar大鼠按照体重和血脂水平随机分成5组,分别接受正常饲料、高脂模型对照、高脂饲料加入清知源软胶囊(高、低剂量分别为20、5mg／kg)、阳性药对照灌胃处理。3周后取血测定血脂和抗氧化酶的含量。 结果 :与高脂模型组大鼠相比,清知源软胶囊组可以显著降低大鼠血清TC、TG、LDL-C、MDA含量,升高血清 HDL-C含量,使血清和肝组织超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性上升,丙二醛 (MDA)含量降低(P<0.05)。 结论 :清知源软胶囊可以明显地调节血脂,提高抗氧化能力,抑制脂质过氧化。
Abstract:
Objective : To study the effects of Qingzhiyuan soft capsule(QZY)on blood lipid and antioxidant activity in hyperlipi-demia rats. Methods : Fifty Wister rats were randomly divided into five groups according to body weight and serum cholesterol levels.They were fed one of five diets, a reference diet, a high fat supplemented diet and a high fat supplemented with 20mg/kg, 5mg/kg QZY, a positive diets.After three weeks, blood lipid and antioxidant activity were determined respectively. Results : Compared with model, QZY could reduced the serum TC, TG, LDL-C concentration, increased SOD and GSH-Px activities, decreased MDA level significantly(P<0.05). Conclusion : QZY might play an important role in preventing hyperlipidemia through its antioxidative effect.
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