金黄地鼠和大鼠高血脂模型的应用研究

李林鹏; 孙浚雯; 曹永兵; 任天舒; 姜远英; 孙德好

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金黄地鼠和大鼠高血脂模型的应用研究

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好

文章导航 > 药学实践与服务 > 2007 > (6): 369-371

董珂. 大孔树脂技术在中药研究中的应用概况[J]. 药学实践与服务, 2006, (1): 13-16.

引用本文:

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好. 金黄地鼠和大鼠高血脂模型的应用研究[J]. 药学实践与服务, 2007, (6): 369-371.

LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.

Citation:

LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.

金黄地鼠和大鼠高血脂模型的应用研究

1.
第二军医大学药学院药理学教研室,上海200433
2.
第二军医大学流行病学教研室,上海200433
3.
中国人民解放军第411医院,上海200081

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

1.
Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China
2.
Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China
3.
Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

摘要: 目的:通过比较辛伐他汀在Wistar大鼠与金黄地鼠两种高血脂模型中的作用,分析两种高血脂模型的合理应用。方法:取Wistar大鼠和金黄地鼠各30只,大鼠体重200-230 g,金黄地鼠体重100-130 g,各随机分成空白对照组、模型对照组以及辛伐他汀组各10只。确认模型建立成功后,两给药组分别给予辛伐他汀10 mg/（kg.d）,并于给药第14、28天测定血清TC和LDL-C。分析辛伐他汀在两种动物高血脂模型中的作用。结果:辛伐他汀能抑制Wistar大鼠血脂升高的趋势和降低高血脂症金黄地鼠的血脂水平。Wistar大鼠对辛伐他汀的降脂作用较金黄地鼠更为敏感。结论:Wistar大鼠高血脂模型对辛伐他汀的降脂作用更为敏感,作为某些降血脂药物如他汀类活性筛选动物模型具有其优势。而金黄地鼠胆固醇的合成代谢与人类更为接近,其高血脂模型更有利于进行某些降血脂新药的临床前评价。
- 高血脂症 /
- 金黄地鼠 /
- Wistar大鼠 /
- 辛伐他汀
Abstract: Objective :To compare the effect of simvastatin in the hyperlipemia model of the golden hamster and the Wistar rat,discuss the reasonable application of the two animal hyperlipemia models. Methods :Thirty male golden hamsters weighing 100-130 g and thirty male Wistar rat weighing 200-300 g were respectively randomized into 3 groups with 10 in each,named as the normal group,model group and simvastatin group.After the models of hyperlipemia were established,the simvastatin groups were treated with the dosage of 10mg/（kg·d） simvastatin.Observe the effect of simvastatin on lipid level in the 14th and 28th day.Analysed the effect of simvastatin in the two hyperlipemia models. Results :Simvastatin decreased the lipid level of the two hyperlipemia model.The effect in Wistar rat is better than in golden hamster. Conclusion : Wistar rat is more susceptible to simvastatin than golden hamster.The hyperlipemia model of Wistar rat is adapt to the application of the selection of cholesterol-lowering drugs.The hyperlipemia model of golden hamster is suit to the before clinical research of the novel cholesterol-lowering drugs.
- hyperlipemia /
- hamster /
- Wistar rat /
- simvastatin

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金黄地鼠和大鼠高血脂模型的应用研究

1. 第二军医大学药学院药理学教研室,上海200433

2. 第二军医大学流行病学教研室,上海200433

3. 中国人民解放军第411医院,上海200081

收稿日期: 2007-04-11

关键词:

摘要: 目的:通过比较辛伐他汀在Wistar大鼠与金黄地鼠两种高血脂模型中的作用,分析两种高血脂模型的合理应用。方法:取Wistar大鼠和金黄地鼠各30只,大鼠体重200-230 g,金黄地鼠体重100-130 g,各随机分成空白对照组、模型对照组以及辛伐他汀组各10只。确认模型建立成功后,两给药组分别给予辛伐他汀10 mg/（kg.d）,并于给药第14、28天测定血清TC和LDL-C。分析辛伐他汀在两种动物高血脂模型中的作用。结果:辛伐他汀能抑制Wistar大鼠血脂升高的趋势和降低高血脂症金黄地鼠的血脂水平。Wistar大鼠对辛伐他汀的降脂作用较金黄地鼠更为敏感。结论:Wistar大鼠高血脂模型对辛伐他汀的降脂作用更为敏感,作为某些降血脂药物如他汀类活性筛选动物模型具有其优势。而金黄地鼠胆固醇的合成代谢与人类更为接近,其高血脂模型更有利于进行某些降血脂新药的临床前评价。

English Abstract

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

1. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

2. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

3. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

Received Date: 2007-04-11

Keywords:

Abstract: Objective :To compare the effect of simvastatin in the hyperlipemia model of the golden hamster and the Wistar rat,discuss the reasonable application of the two animal hyperlipemia models. Methods :Thirty male golden hamsters weighing 100-130 g and thirty male Wistar rat weighing 200-300 g were respectively randomized into 3 groups with 10 in each,named as the normal group,model group and simvastatin group.After the models of hyperlipemia were established,the simvastatin groups were treated with the dosage of 10mg/（kg·d） simvastatin.Observe the effect of simvastatin on lipid level in the 14th and 28th day.Analysed the effect of simvastatin in the two hyperlipemia models. Results :Simvastatin decreased the lipid level of the two hyperlipemia model.The effect in Wistar rat is better than in golden hamster. Conclusion : Wistar rat is more susceptible to simvastatin than golden hamster.The hyperlipemia model of Wistar rat is adapt to the application of the selection of cholesterol-lowering drugs.The hyperlipemia model of golden hamster is suit to the before clinical research of the novel cholesterol-lowering drugs.

董珂. 大孔树脂技术在中药研究中的应用概况[J]. 药学实践与服务, 2006, (1): 13-16.

引用本文:

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好. 金黄地鼠和大鼠高血脂模型的应用研究[J]. 药学实践与服务, 2007, (6): 369-371.

Citation:

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金黄地鼠和大鼠高血脂模型的应用研究

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

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金黄地鼠和大鼠高血脂模型的应用研究

1. 第二军医大学药学院药理学教研室,上海200433 2. 第二军医大学流行病学教研室,上海200433 3. 中国人民解放军第411医院,上海200081

English Abstract

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

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1. 第二军医大学药学院药理学教研室,上海200433

2. 第二军医大学流行病学教研室,上海200433

3. 中国人民解放军第411医院,上海200081