pH对酒石酸溴莫尼定滴眼液稳定性的影响
Effect of pH on the stability of brimonidine tartrate eye drops
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摘要: 目的: 考察pH对酒石酸溴莫尼定滴眼液稳定性的影响,确定本品最佳的pH范围及贮存条件。 方法: 采用HPLC法测定酒石酸溴莫尼定滴眼液的含量及有关物质,考察本品在强光、高温条件下的稳定性。 结果: 酒石酸溴莫尼定滴眼液对强光、高温较敏感,且随着pH值的升高,稳定性下降。 结论: 本品最适宜的pH范围为偏酸性,最适宜的贮存条件为低温、避光。
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关键词:
- 酒石酸溴莫尼定滴眼液 /
- pH /
- 稳定性
Abstract: Objective:To study the effect of pH on stability of brimonidine tartrate eye drops and to determine the optimal range of pH and storage conditions of it.Methods:HPLC methed was used for the determination of content and related substance of brimonidine tartrae eye drops.The stability of the preparation at high temperature and intense light illumination was studied.Results:Brimonidine tartrae eye drops was sensitive to high temperature and strong illumination.The stability of the preparation would get lower with the in- crease of pH.Conclusion:The optimum pH of the preparation was partial to acidity,and the optimum storage condition was low tem- perature and away from light.-
Key words:
- brimonidine tartrate /
- pH /
- stability
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