取代咪唑酮合成工艺研究
Study on the synthesis of replaced imidazole
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摘要: 目的: 优化取代咪唑酮类化合物的合成工艺。 方法: 采用正交设计法,重点考察反应溶剂,投料比例及温度对收率的影响。 结果: 投料比例对收率的影响最为显著。 结论: 使收率由低于10%提高到42.5%,使得更加符合工业生产的要求。Abstract: Objective: To optimize the synthesis of replaced imidazole. Methods: Orthogonal experimental design was used and the influence of temperature,reactant ratio and solvent on the yield were investigated. Results: Reactant ratio was more important than the others.The yield was improved from less than 10%to 42.5%. Conclusion: The optimal preparation procedure is stable and available for industrial production.
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Key words:
- replaced imidazole /
- synthesis /
- orthogonal experimental design
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