微波及离子液体条件下香豆素类化合物的合成研究
Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid
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摘要: 目的:探索操作简便、环境友好的香豆素衍生物的合成方法。方法:以乙酰乙酸乙酯和苯酚类化合物为原料,通过Pechmann反应,在4种不同的反应条件(浓硫酸催化、Lewis酸三氯化铋催化、微波Lewis酸三氯化铋催化、微波离子液体催化)下催化合成多种香豆素衍生物,并对4种方法进行对比。结果:微波离子液体条件下的Pechmann反应与传统方法相比革除了有机溶剂的使用,缩短了反应时间且产率较高。结论:微波及离子液体条件下合成香豆素类化合物是一种条件简单、环境友好的合成方法。
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关键词:
- 香豆素类化合物 /
- 微波加热 /
- 离子液体 /
- Pechmann反应
Abstract: Objective :To explore an easily-controled,environmentally-benign synthetic method of coumarin derivatives. Methods :Several coumarin derivatives are synthesized from phenols and ethyl acetoacetates by the Pechmann reaction under four different conditions(H2SO4,BiCl3,Microwave/BiCl3,Microwave/ionic liquid). Results :Compared with traditional reaction,present method under microwave and ionic liquid avoids using of organic solvent,shorten the reaction period and obtain a good yield. Conclusion :Microwave accelerated Pechmann reaction using ionic liquid as catalyst is a convenient and green alternative for synthesizing coumarin derivatives.-
Key words:
- coumarin derivatives /
- microwave irradiation /
- ionic liquid /
- Pechmann reaction
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